Abstract: A battery manager for a battery is disclosed. The battery manager comprises a battery charger configured to provide a first output voltage in a first voltage range, a buck-boost direct current to direct current (DC to DC) converter switchably coupled to the battery charger, and a bypass line switchably coupled between the battery charger and the battery for bypassing the buck-boost DC to DC converter. The battery manager further comprises a controller configured to electrically route the first output voltage of the battery charger to the battery via the bypass line when a voltage requirement of the battery is within the first voltage range. The controller is further configured to electrically route the first output voltage of the battery charger to the battery via the buck-boost DC to DC converter when the voltage requirement of the battery is outside the first voltage range.

Abstract: A connector port assembly for releasably securing an implantable lead to a header of an implantable medical device comprises a connector block having a connector block bore and an access hole extending radially through the connector block and oriented orthogonally to an axis of the connector block bore and sized to receive a shaft of a release tool, and a collet assembly including a collet body and a plurality of bearings arranged about a circumference of the collet body, the collet body including a forward end portion having a curved outer surface, and a distal portion opposite the forward end portion, wherein the access hole of the connector block is positioned such that a shaft of the release tool can engage the curved outer surface of the forward end portion of the collet body.

Abstract: A device and method for treating high-altitude sickness can include a handheld device, and can deliver a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.

Abstract: Dinitrogen tetroxide (N2O4) is synthesized in an apparatus by the reaction of concentrated nitric acid with copper. Oxygen is applied as a carrier gas to convert NO to NO2, and water vapor is removed with a tube dryer. A molecular sieve is applied to reduce and remove impurities.

Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

Abstract: Methods, systems, and media for determining and presenting information related to embedded sound recordings are provided.

Abstract: Disclosed herein are methods for identifying mutations from a patient sample, by evaluating, using a computer having a machine learning classifier, a candidate variant against a plurality of decision trees trained to detect mutations in the candidate variant with a gradient boosting algorithm.

Abstract: Disclosed herein are methods of detecting differential over-expression of 3? exons relative to 5? exons of the Neurotrophic Tyrosine Receptor Kinase (NTRK) gene to facilitate the identification of subjects having NTRK fusion proteins. Additionally, methods of treating cancer by administering NTRK inhibitors to a subject identified as having tumors which express NTRK fusion protein, are also disclosed.

Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

Abstract: A method, apparatus, and system provide the ability to act on cyber risks and reduce cyber attacks. System characteristics and system information for a cyber system are gathered. The system characteristics and system information are pre-processed to identify vulnerabilities that are relevant to the cyber system. A system model of a cyber environment is generated for the cyber system. One or more features are converted from cyber threat reports to one or more semantically relevant queries over the system model. The system model is reasoned over to generate one or more answers relevant to the one or more semantically relevant queries. Attack models are executed over the system model to generate actionable intelligence and reduce cyber attacks.

Abstract: A non-invasive product customization system and a method of customizing a product formulation is provided. Brain activity of a user is detected in response to an input of a product formulation into a brain of the user via a sensory nervous system of the user. A mental state of the user is detected based on the detected brain activity. The product formulation is modified based on the determined mental state of the user. The modified product formulation may be presented to the user in a manner that modulates the mental state of the user.

Abstract: Disclosed herein are methods of assessing whether a subject would be responsive to an immunotherapy.

Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

Abstract: A water testing and measuring system is disclosed including a water generator configured to generate water by extracting water vapor from ambient air. A compound generator is configured to apply a compound to the water generated by the water generator. A processor is in communication with the water generator and the compound generator. A measurement device is in communication with the water generator, the compound generator and the processor.

Abstract: A mental state awareness system comprises a non-invasive brain interface assembly configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.

Abstract: Some embodiments include a system operable to construct hierarchical training data sets for use with machine-learning for multiple controlled devices. Other embodiments of related systems and methods are also provided.

Abstract: Start-up protocols for a device and method for administering NO is described.

Abstract: A system for deliverying a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.

Abstract: An illustrative system includes an extended reality system and a brain interface system configured to be concurrently worn by a user. The extended reality system is configured to provide the user with an extended reality experience and output a timing signal while the extended reality experience is being provided to the user, the timing signal representing a plurality of timing events that occur during the extended reality experience. The brain interface system is configured to receive the timing signal from the extended reality system while the extended reality experience is being provided to the user, acquire brain activity measurements while the extended reality experience is being provided to the user, and output measurement timestamp data representative of a temporal association of the brain activity measurements with the timing events.

Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.