Abstract: Provided are monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-1R binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. AntiErbB3 and anti-IGF-1R antibodies (e.g., monoclonal antibodies) are also provided.

Abstract: The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection.

Abstract: Embodiments of the invention are related to ionic liquids and more specifically to ionic liquids used in electrochemical metal-air cells in which the ionic liquid includes a cation and an anion selected from hydroxamate and/or N-alkyl sulfamate anions.

Abstract: A moveable wall system and components therefore, including: 1. A flexible power connector configured to flex in only one direction whereby it can be pushed without buckling; 2. at least one wireless power transmission receiving station in one or more of the moveable wall and modular units mounted thereon, for receiving the wireless transmission of power and enable one to charge electronic devices and provide power to power receiving lamps or the like, without the need for plug-in electrical wiring: 3. an overhead track system for supporting the moveable wall laterally below at least two spaced, parallel tracks, the wall including a core support member having at least two spaced frame members secured to the top of said core support and projecting laterally to either or both sides of core support, each including a pair of trolleys for suspending said moveable wall in said parallel overhead tracks, projecting upwardly from its respective frame member and engaging their respective track.

Abstract: A moveable table for use in reconfiguring living and work space has a work surface and a support for supporting said work surface at a position above floor level, and at least one wireless power transmission receiving station in said moveable table, for receiving the wireless transmission of power and enable one to charge electronic devices on said table and provide power to power receiving lamps or the like on said table, without the need for plug-in electrical wiring.

Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.

Abstract: A reconfigurable space system and components therefore which can be reconfigured to accommodate sleeping space, entertainment space, work space, kitchen space, dining space and various combinations thereof.

Abstract: A void protection system for a mining shovel having an operator input device includes an independent metering valve assembly including one or more fluid source-cylinder valves for fluidly connecting the fluid source to the hydraulic cylinder. The system also includes a sensor assembly for monitoring the fluid pressure within the rod end and the head end of the hydraulic cylinder, and a control module. The control module is configured to monitor movement of the operator input device, monitor pressure within the hydraulic cylinder, increase the opening of the corresponding fluid source-cylinder valve and increase fluid flow from the fluid source to fill corresponding end of the hydraulic cylinder until pressure in the corresponding end of the hydraulic cylinder is above a first threshold pressure.

Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

Abstract: Systems and methods are disclosed for determining locations visited by a mobile device. In an embodiment, a first location point is identified from a plurality of location points associated with the mobile device. The first location point may be combined with one or more of the plurality of location points to construct a time block. A time block may indicate a continuous period of time when the mobile device is in the same location. An aggregate location is calculated for the time block based on the plurality of points in the time block. One or more time blocks may be grouped based on the aggregate location of each time block, and a spatial clustering procedure is applied to transform the aggregate locations of time blocks in the group into one or more locations of interest.

Abstract: Methods of preparing sulfate salts of heteroatomic compounds using dialkyl sulfates as a primary reactant are disclosed. Also disclosed are methods of making ionic liquids from the sulfate salts of the heteroatomic compound, and electrochemical cells comprising the ionic liquids.

Abstract: Embodiments of the invention are related to anion exchange membranes used in electrochemical metal-air cells in which the membranes function as the electrolyte material, or are used in conjunction with electrolytes such as ionic liquid electrolytes.

Abstract: Provided are methods for the administration of therapeutic bispecific anti-IGF-1R and anti-ErbB3 antibodies, either alone or in combination with other anti-cancer therapeutics.

Abstract: Embodiments of the invention are related to ionic liquids and more specifically to ionic liquids used in electrochemical metal-air cells in which the ionic liquid includes a cation and an anion selected from hydroxamate and/or N-alkyl sulfamate anions.

Abstract: A reconfigurable space system and components therefore which can be reconfigured to accommodate sleeping space, entertainment space, work space, kitchen space, dining space and various combinations thereof.

Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

Abstract: A hydraulic control system is disclosed. The hydraulic control system may have a pump configured to pressurize a fluid, an actuator, a position sensor associated with the actuator and configured to generate a first signal indicative of a position of the actuator, and a circuit fluidly connecting the pump to the actuator. The hydraulic control system may also have a valve associated with the circuit and configured to move from a first position, at which fluid relief from the circuit is inhibited, toward a second position, at which fluid is relieved from the circuit through the valve, when a pressure of fluid within the circuit exceeds a threshold setting of the valve. The hydraulic control system may additionally have a controller in communication with the position sensor and the valve. The controller may be configured to selectively cause adjust the threshold setting of the valve based on the first signal.

Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir including a restrictor with a length of at least 0.5 inch and at most 2 inches covered by a metal sheath, a gas supply, and a delivery conduit. A delivery conduit can include at least one cartridge and a patient interface. The at least one cartridge can include a surface-active material and a reducing agent.

Abstract: A void protection system for a mining shovel having an operator input device includes an independent metering valve assembly including one or more fluid source-cylinder valves for fluidly connecting the fluid source to the hydraulic cylinder. The system also includes a sensor assembly for monitoring the fluid pressure within the rod end and the head end of the hydraulic cylinder, and a control module. The control module is configured to monitor movement of the operator input device, monitor pressure within the hydraulic cylinder, increase the opening of the corresponding fluid source-cylinder valve and increase fluid flow from the fluid source to fill corresponding end of the hydraulic cylinder until pressure in the corresponding end of the hydraulic cylinder is above a first threshold pressure.

Abstract: A hydraulic system for a machine is disclosed. The hydraulic system may have a first pump with variable displacement and being load-sense controlled, and a first hydraulic circuit associated with the first pump. The hydraulic system may also have a second pump with variable displacement and being electro-hydraulically controlled, and a second hydraulic circuit associated with the second pump. The hydraulic system may further have a flow-sharing valve arrangement configured to selectively share fluid flow between the first and second hydraulic circuits.