Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal region, an imaging window region, and a distal end region having a guidewire lumen formed therein. The catheter shaft may include a telescoping assembly having a telescope hub configured to be secured to a pullback assembly. The telescope hub may include a proximal flange, a loading region disposed distal of the proximal flange, and a grip region disposed distal of the loading region. The grip region may have a non-circular cross-sectional shape. An imaging core may be disposed within the catheter shaft.

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. A bumper tip member may be disposed along the distal tip region. A marker member may be disposed adjacent to the bumper tip member. The marker member may include an inner layer, a tie layer, and an outer layer including a radiopaque material. A sleeve may be disposed over and couple the bumper tip member and the marker member. An imaging core may be disposed within the catheter shaft.

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. The distal tip region may include a bumper tip member, a radiopaque member, and a sleeve disposed over and coupling the bumper tip member and the radiopaque member. An imaging core may be disposed within the catheter shaft.

Abstract: Imaging medical device systems and methods for making and using imaging medical device systems are disclosed. An example imaging medical device system may include an elongate shaft having a distal end region. An imaging assembly may be disposed within the elongate shaft. The imaging assembly may include a drive cable, a housing coupled to the drive cable, and a transducer coupled to the housing. A bubble-reducing member may be disposed adjacent to the drive cable.

Abstract: The invention provides a rapid leaching and dewatering system for the remediation of PFAS-contaminated solid matrix material (e.g., soil, sediment, and/or sludge material) for the removal of PFAS compounds, and other contaminants, therefrom. The system mobilizes contaminants from a solid state (soil/sediment/sludge) to a liquid state resulting in a clean solid material.

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a hypotube region, an imaging window region, and a distal end region having a guidewire lumen formed therein. The hypotube region may include a first portion free of slots and a second portion having a plurality of slots formed therein. At least a reduced diameter section of the second portion of the hypotube region may have an outer diameter that is less than an outer diameter of the first portion of the hypotube region. The imaging window region may be coupled to the reduced diameter section of the second portion of the hypotube region. An imaging core may be disposed within the catheter shaft.

Abstract: Video messaging systems and methods utilize a video messaging component based on a video messaging component container stored in a data store. The video messaging component container includes a collaborative video list that shows a list of video content generated by users of the video messaging component. Iterations of the video messaging component are rendered in host applications on client devices. As video content is generated by the iterations, the collaborative video list is updated to include the video content, and the iterations of the video messaging component are updated to reflect changes to the collaborative video list in real-time.

Abstract: In one embodiment, a system includes a multistage dielectrophoretic filter system for purification of extracellular vesicles from a complex sample comprising an array of fluidic cells having electrodes that receive and process the sample, fluid transfer devices, actuated valves, storage containers, an electronic control board and power supply. In another embodiment, an extracellular vesicle analysis system for analyzing biomarkers in the purified extracellular vesicles is described. In yet another embodiment are described methods for purifying extracellular vesicles, and analyzing extracellular vesicle biomarker profiles for identifying subjects for treatment or for diagnosis.

Abstract: A storytelling interface comprising a map panel and a genealogy panel, and methods for using the same, are described. The storytelling interface facilitates dynamic and automatic scaling and relocation of the map panel based on a user's location within the genealogy panel, which facilitates a continuous scrolling operation to navigate between different sections of the genealogy panel. The storytelling interface facilitates a user receiving, viewing, and interacting with DNA and ethnic communities results determined from DNA testing, and allows a user to navigate through pertinent communities in both time and/or space.

Abstract: A cable routing storage assembly for a data communication system chassis. The assembly including a shuttle including a base portion spanning between a first side of the shuttle and a second side of the shuttle. A slot is defined within the base portion and arranged between the first side and the second side. The slot extending from the back end of the shuttle along a portion of a length of the shuttle to a point proximate to a front end of the shuttle such that the base portion at the back end of the shuttle is separated between the first side and the second side. The slot being sized to slideably receive a mounting structure disposed in the chassis. A handle extends from a front end of the shuttle in front of the slot. The handle being configured to displace the shuttle relative to the chassis.

Abstract: Co-curable and co-cured UV/visible light-resistant composite material assembly precursors used to make composite material assemblies comprise a compatible co-curable and co-cured peel ply protective layer to impart selected surface characteristics to the co-curable and co-cured composite material assembly precursor prior to peel ply removal and composite material precursor incorporation into a larger assembly are disclosed.

Abstract: The present invention is directed to a system and method for digital, multiplexed, extracellular vesicle-derived biomarker diagnostic lab-on-a-chip and method of use thereof. The present invention provides a minimally invasive system and method for early disease detection using extracellular vesicles as biomarkers for disease. Extracellular vesicles are collected from a fluid biological sample and subjected to a sorting process which provide a purified liquid containing the biomarkers of interest.

Abstract: The teachings herein relate to sound damping materials and particularly to sound damping materials for castings. The sound damping material includes a surface layer including an elastomer and a filler. Preferably the filler includes glass or ceramic beads. The surface layer preferably has a textured surface for contacting with the casting. Preferably the filler has a diameter that provides or contributes to the textured surface. For example, a portion of the filler may have a diameter that is greater than the average thickness of the surface layer. The sound damping material includes one or more metallic layers, preferably for applying a force to a surface of the casting. The sound damping material preferably includes two metallic layers that are separated by a core polymeric layer.

Abstract: A data communication apparatus includes a chassis. The chassis includes a front access side, a rear side, a rear wall disposed at the rear side, and a shelf extending at the rear side away from the front access side. A breakout module has a front end opposite a back end and is removeably disposable at least partially in the chassis. The breakout module includes a first adaptor disposed at the front end and a second adapter disposed in the back end. A cable module is removeably disposable on the surface of the shelf such that the cable module is not disposed in the chassis, the cable module including a spool configured to hold a fiber optic cable.

Abstract: This disclosure relates generally to lab-on-chip diagnostic platforms, and in particular, relates to detection of extracellular vesicle biomarkers using lab-on-a-chip diagnostics. The properties of extracellular vesicles provide the opportunity for early detection of biomarkers corresponding to early disease. Combinatorial detection of the presence of multiple cancer-associated biomarkers from extracellular vesicles along with analysis with advanced machine learning algorithms, may be useful for sensitive and specific diagnosis of early cancer and other diseases from biological fluids. Disclosed herein are compositions, methods, and exosome detection apparatus for biomarker detection.

Abstract: A storytelling interface comprising a map panel and a genealogy panel, and methods for using the same, are described. The storytelling interface facilitates dynamic and automatic scaling and relocation of the map panel based on a user's location within the genealogy panel, which facilitates a continuous scrolling operation to navigate between different sections of the genealogy panel. The storytelling interface facilitates a user receiving, viewing, and interacting with DNA and ethnic communities results determined from DNA testing, and allows a user to navigate through pertinent communities in both time and/or space.

Abstract: An ultrasound catheter includes a distal port and a proximal port and is adapted to provide fluid communication between the distal port and the proximal port. The ultrasound catheter includes an ultrasound transducer. The ultrasound catheter may be advanced through a guide catheter that is positioned within a patient's vasculature and is fluidly coupled with the patient's blood. A vacuum may be applied to the proximal port, causing the patient's blood to be slowly pulled into the ultrasound catheter through the distal port such that any air near the ultrasound transducer is replaced with the patient's blood and the ultrasound transducer is surrounded by the patient's blood, which is an optimal imaging medium. The ultrasound transducer may be operated to obtain ultrasound images while applying the vacuum to the proximal port.

Abstract: A cover extension can be installed above or below a wall-mounted electrical panel (e.g., a circuit breaker panel) to cover an opening in the wall immediately above or below the panel. The cover extension includes a panel member, a bottom flange, and two top couplings and stop members. The flange extends downwards from the panel member bottom and is offset from the panel member so that it can fit behind the panel cover of the electrical panel to secure the cover extension bottom to the panel cover. The mechanical stops (e.g., brackets) are located on the panel member rear face and configured to each cause the respective coupling member on the panel member rear face to engage the cover extension to secure the cover extension top to the wall.