Patents by Inventor Bryan Joseph Rice

Bryan Joseph Rice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240382958
    Abstract: The present invention is directed to a system and method for digital, multiplexed, extracellular vesicle-derived biomarker diagnostic lab-on-a-chip and method of use thereof. The present invention provides a minimally invasive system and method for early disease detection using extracellular vesicles as biomarkers for disease. Extracellular vesicles are collected from a fluid biological sample and subjected to a sorting process which provide a purified liquid containing the biomarkers of interest.
    Type: Application
    Filed: May 17, 2024
    Publication date: November 21, 2024
    Inventor: Bryan Joseph Rice
  • Publication number: 20240319201
    Abstract: This disclosure relates generally to lab-on-chip diagnostic platforms, and in particular, relates to detection of extracellular vesicle biomarkers using lab-on-a-chip diagnostics. The properties of extracellular vesicles provide the opportunity for early detection of biomarkers corresponding to early disease. Combinatorial detection of the presence of multiple cancer-associated biomarkers from extracellular vesicles along with analysis with advanced machine learning algorithms, may be useful for sensitive and specific diagnosis of early cancer and other diseases from biological fluids. Disclosed herein are compositions, methods, and exosome detection apparatus for biomarker detection.
    Type: Application
    Filed: February 9, 2024
    Publication date: September 26, 2024
    Inventor: Bryan Joseph Rice
  • Publication number: 20230417702
    Abstract: In one embodiment, a method for isolating and detection one or more biomarkers of interest on a dielectrophoresis device includes receiving a first biological sample containing one or more biomarkers of interest onto a dielectrophoresis (DEP) electrode array, applying a DEP force through particular electrodes of the DEP electrode array, wherein a strength, direction, and period of time of the DEP force is specific to the one or more biomarkers of interest of the first biological sample, and determining, via a digital sensor, a quantity of the one or more biomarkers of interest of the first biological sample.
    Type: Application
    Filed: June 22, 2023
    Publication date: December 28, 2023
    Inventors: Bryan Joseph Rice, Richard Louis Young, Amber Noelle Murray, Tyler Lee Harris, Jordan Alexandra Saalfeld, Daniel Philip Heineck