Patents by Inventor Bryan Klekota

Bryan Klekota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6599754
    Abstract: A reaction vessel and method of identifying a ligand having affinity for a target molecule are disclosed. The reaction vessel includes a first member defining a first chamber, the first chamber including an organic solvent and a plurality of reactants which form a combinatorial library of products; a second member defining a second chamber, the second chamber including a target molecule and an aqueous solvent immiscible in the organic solvent; and a semipermeable membrane separating the contents of the first chamber from the contents of the second chamber, wherein said semipermeable membrane is permeable to one or more products of the combinatorial library of products.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: July 29, 2003
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Bryan Klekota
  • Publication number: 20020160413
    Abstract: The present invention relates to a combinatorial library which includes a plurality of at least six different complexes. Each of the complexes is formed of at least one complexing agent and at least two non-biopolymer ligands that are reversibly bonded to the complexing agent, and each different complex in the library has different ligands bonded to the complexing agent. Compositions that include these combinatorial libraries and receptors are also disclosed, as are methods for identifying a combination of non-biopolymer ligands which bind preferentially to a receptor. Methods for producing the combinatorial libraries are also described. The combinatorial libraries, compositions, and methods of the present invention permit the selection and amplification of non-biopolymeric molecules which are targeted to a particular receptor, where the selection and amplification criteria are based strictly on differences in binding affinity to a receptor.
    Type: Application
    Filed: October 28, 1998
    Publication date: October 31, 2002
    Inventors: BENJAMIN L. MILLER, BRYAN KLEKOTA
  • Publication number: 20020085955
    Abstract: A reaction vessel and method of identifying a ligand having affinity for a target molecule are disclosed. The reaction vessel includes a first member defining a first chamber, the first chamber including an organic solvent and a plurality of reactants which form a combinatorial library of products; a second member defining a second chamber, the second chamber including a target molecule and an aqueous solvent immiscible in the organic solvent; and a semipermeable membrane separating the contents of the first chamber from the contents of the second chamber, wherein said semipermeable membrane is permeable to one or more products of the combinatorial library of products.
    Type: Application
    Filed: April 20, 2001
    Publication date: July 4, 2002
    Inventors: Benjamin L. Miller, Bryan Klekota
  • Patent number: D708026
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: July 1, 2014
    Inventor: Bryan Klekota