Patents by Inventor Bryan Knuckley

Bryan Knuckley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptoid-based inhibitors of the protein arginine methyltransferase (PRMT) family
    Patent number: 11993556
    Abstract: Novel peptoid compounds, compositions and methods of using the compounds and compositions to inhibit protein arginine methyltransferase (PRMT) and induce apoptosis in cancer cells are presented.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: May 28, 2024
    Assignee: University of North Florida Board of Trustees
    Inventors: Bryan Knuckley, Corey P. Causey, Fatima Khwaja Rehman
  • Detecting Protein Arginine Deiminase (PAD) Activity in Human Tissues and Sera
    Publication number: 20120295292
    Abstract: Methods for diagnosing disease that is characterized by an overabundance of citrullinated proteins such as colitis, rheumatoid arthritis, and/or malignant cancer in a subject are provided. The PAD protein activity level can be measured in a tissue sample (e.g., serum) of the subject and then compared to a control PAD protein activity range of a control group. A finding of an increased PAD protein activity level in the tissue sample of the subject compared to the PAD protein activity level of the control group is indicative of disease characterized by an overabundance of citrullinated proteins in the subject.
    Type: Application
    Filed: May 21, 2012
    Publication date: November 22, 2012
    Applicant: University of South Carolina
    Inventors: Paul R. Thompson, Lorne J. Hofseth, Bryan A. Knuckley
  • Methods to identify protein arginine deiminase 4 inhibitors
    Patent number: 8007996
    Abstract: In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: August 30, 2011
    Assignee: University of South Carolina
    Inventors: Paul R. Thompson, Bryan Knuckley
  • Methods to Identify Protein Arginine Deiminase 4 Inhibitors
    Publication number: 20090162877
    Abstract: In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay.
    Type: Application
    Filed: October 31, 2008
    Publication date: June 25, 2009
    Applicant: University of South Carolina
    Inventors: Paul Ryan Thompson, Bryan Knuckley