Patents by Inventor Bryan L. Smith

Bryan L. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12616689
    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.
    Type: Grant
    Filed: August 30, 2023
    Date of Patent: May 5, 2026
    Assignees: 60 Degrees Pharmaceuticals, Inc., THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
  • Publication number: 20250339400
    Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.
    Type: Application
    Filed: July 11, 2025
    Publication date: November 6, 2025
    Applicant: AMIVAS, INC.
    Inventors: Bryan L. Smith, Lisa Thomas Read
  • Publication number: 20250262184
    Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.
    Type: Application
    Filed: October 7, 2024
    Publication date: August 21, 2025
    Applicant: AMIVAS, INC.
    Inventors: Bryan L. Smith, Lisa Thomas Read
  • Patent number: 12390442
    Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.
    Type: Grant
    Filed: October 7, 2024
    Date of Patent: August 19, 2025
    Assignee: AMIVAS, INC.
    Inventors: Bryan L. Smith, Lisa Thomas Read
  • Publication number: 20250073222
    Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.
    Type: Application
    Filed: April 19, 2024
    Publication date: March 6, 2025
    Applicant: 60 DEGREES PHARMACEUTICALS LLC
    Inventors: Geoffrey S. DOW, Bryan L. SMITH
  • Publication number: 20240408074
    Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.
    Type: Application
    Filed: April 19, 2024
    Publication date: December 12, 2024
    Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc., Yale Universtiy
    Inventors: Geoffrey S. Dow, Bryan L. Smith, Edouard Vannier, Peter J. Krause
  • Publication number: 20240390359
    Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.
    Type: Application
    Filed: April 19, 2024
    Publication date: November 28, 2024
    Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc.
    Inventors: Geoffrey S. DOW, Bryan L. Smith, Edouard Vannier
  • Patent number: 12121506
    Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.
    Type: Grant
    Filed: February 16, 2024
    Date of Patent: October 22, 2024
    Assignee: AMIVAS, INC.
    Inventors: Bryan L. Smith, Lisa Thomas Read
  • Publication number: 20240082233
    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.
    Type: Application
    Filed: August 30, 2023
    Publication date: March 14, 2024
    Applicants: 60 DEGREES PHARMACEUTICALS LLC, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Geoffrey S. DOW, Bryan L. SMITH, John P. JONES, Moshe SHMUKLARSKY, Budda BALASUBRAHMANYAM
  • Patent number: 11744828
    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: September 5, 2023
    Assignees: 60 Degrees Pharmaceuticals LLC, The Government Of The United States As Represented By The Secretary Of The Army
    Inventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
  • Publication number: 20230225507
    Abstract: The extension limiter for drawer glides prevents a mobile track of a drawer glide from being fully extended with respect to the middle track of the drawer glide until a user takes a specific action to release the mobile track. The extension limiter for drawer glides is a safety measure to prevent accidental tipping of filing cabinets and the like. Additionally, a fixed track for a drawer glide is provided with a reinforced stopper positioned adjacent a rear end of the fixed track to prevent a rear end of the middle track from moving rearward beyond the rear end of the fixed track. A drawer glide is further provided with at least one spacer including a head portion and a peg. The peg extends outwardly from the head portion and removably snaps into a screw hole of the drawer glide so that the head portion is flush with the glide.
    Type: Application
    Filed: January 17, 2022
    Publication date: July 20, 2023
    Inventor: BRYAN L. SMITH
  • Publication number: 20210267962
    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.
    Type: Application
    Filed: January 11, 2021
    Publication date: September 2, 2021
    Applicants: 60 Degrees Pharmaceuticals LLC, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
  • Patent number: 10888558
    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: January 12, 2021
    Assignees: 60 Degrees Pharmaceuticals LLC, The Government Of The United States As Represented By The Secretary Of The Army
    Inventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
  • Publication number: 20190328723
    Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.
    Type: Application
    Filed: July 8, 2019
    Publication date: October 31, 2019
    Applicants: 60 Degrees Pharmaceuticals LLC, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
  • Patent number: 10371566
    Abstract: Liquid tank measuring systems that weigh/measure the amount of liquid in a fixed tank/vessel are disclosed. Also disclosed are methods that provide load cell failure detection of the liquid tank measuring system and the ability to continue operations post load cell failure detection.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: August 6, 2019
    Assignee: Air Liquide Electronics U.S. LP
    Inventors: Bryan L. Smith, Mark Stang, Mike Miano, Billy W. Luetkahans, Daniel J. Fuchs, Matt Kelly, Bryon Perkins, Justin Gauthier, Kevin T. O'Dougherty
  • Patent number: 9855589
    Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: January 2, 2018
    Assignee: Stratasys, Inc.
    Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
  • Patent number: 9592539
    Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: March 14, 2017
    Assignee: Stratasys, Inc.
    Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
  • Publication number: 20150209836
    Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.
    Type: Application
    Filed: April 6, 2015
    Publication date: July 30, 2015
    Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
  • Publication number: 20110186081
    Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.
    Type: Application
    Filed: January 5, 2011
    Publication date: August 4, 2011
    Applicant: STRATASYS, INC.
    Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
  • Patent number: 7376986
    Abstract: A collapsible bunk bed is provided having a first and second bed frame, one of which is positioned vertically above the other to form the bunk bed. The end walls of each bed frame have a hinged joint in the central portion so that the bunk bed may be folded into a collapsed configuration without disassembly of the end walls and side rails.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: May 27, 2008
    Assignee: Folding Bunk Properties (FBP), LLC
    Inventors: Bryan L. Smith, Paulo Renato Zipperer, Frank Real