Patents by Inventor Bryan L. Smith
Bryan L. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12616689Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.Type: GrantFiled: August 30, 2023Date of Patent: May 5, 2026Assignees: 60 Degrees Pharmaceuticals, Inc., THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
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Publication number: 20250339400Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.Type: ApplicationFiled: July 11, 2025Publication date: November 6, 2025Applicant: AMIVAS, INC.Inventors: Bryan L. Smith, Lisa Thomas Read
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Publication number: 20250262184Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.Type: ApplicationFiled: October 7, 2024Publication date: August 21, 2025Applicant: AMIVAS, INC.Inventors: Bryan L. Smith, Lisa Thomas Read
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Patent number: 12390442Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.Type: GrantFiled: October 7, 2024Date of Patent: August 19, 2025Assignee: AMIVAS, INC.Inventors: Bryan L. Smith, Lisa Thomas Read
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Publication number: 20250073222Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.Type: ApplicationFiled: April 19, 2024Publication date: March 6, 2025Applicant: 60 DEGREES PHARMACEUTICALS LLCInventors: Geoffrey S. DOW, Bryan L. SMITH
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Publication number: 20240408074Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.Type: ApplicationFiled: April 19, 2024Publication date: December 12, 2024Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc., Yale UniverstiyInventors: Geoffrey S. Dow, Bryan L. Smith, Edouard Vannier, Peter J. Krause
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Publication number: 20240390359Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.Type: ApplicationFiled: April 19, 2024Publication date: November 28, 2024Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc.Inventors: Geoffrey S. DOW, Bryan L. Smith, Edouard Vannier
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Patent number: 12121506Abstract: Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.Type: GrantFiled: February 16, 2024Date of Patent: October 22, 2024Assignee: AMIVAS, INC.Inventors: Bryan L. Smith, Lisa Thomas Read
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Publication number: 20240082233Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.Type: ApplicationFiled: August 30, 2023Publication date: March 14, 2024Applicants: 60 DEGREES PHARMACEUTICALS LLC, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Geoffrey S. DOW, Bryan L. SMITH, John P. JONES, Moshe SHMUKLARSKY, Budda BALASUBRAHMANYAM
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Patent number: 11744828Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.Type: GrantFiled: January 11, 2021Date of Patent: September 5, 2023Assignees: 60 Degrees Pharmaceuticals LLC, The Government Of The United States As Represented By The Secretary Of The ArmyInventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
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Publication number: 20230225507Abstract: The extension limiter for drawer glides prevents a mobile track of a drawer glide from being fully extended with respect to the middle track of the drawer glide until a user takes a specific action to release the mobile track. The extension limiter for drawer glides is a safety measure to prevent accidental tipping of filing cabinets and the like. Additionally, a fixed track for a drawer glide is provided with a reinforced stopper positioned adjacent a rear end of the fixed track to prevent a rear end of the middle track from moving rearward beyond the rear end of the fixed track. A drawer glide is further provided with at least one spacer including a head portion and a peg. The peg extends outwardly from the head portion and removably snaps into a screw hole of the drawer glide so that the head portion is flush with the glide.Type: ApplicationFiled: January 17, 2022Publication date: July 20, 2023Inventor: BRYAN L. SMITH
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Publication number: 20210267962Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.Type: ApplicationFiled: January 11, 2021Publication date: September 2, 2021Applicants: 60 Degrees Pharmaceuticals LLC, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
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Patent number: 10888558Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.Type: GrantFiled: July 8, 2019Date of Patent: January 12, 2021Assignees: 60 Degrees Pharmaceuticals LLC, The Government Of The United States As Represented By The Secretary Of The ArmyInventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
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Publication number: 20190328723Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.Type: ApplicationFiled: July 8, 2019Publication date: October 31, 2019Applicants: 60 Degrees Pharmaceuticals LLC, THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Geoffrey S. Dow, Bryan L. Smith, John P. Jones, Moshe Shmuklarsky, Budda Balasubrahmanyam
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Patent number: 10371566Abstract: Liquid tank measuring systems that weigh/measure the amount of liquid in a fixed tank/vessel are disclosed. Also disclosed are methods that provide load cell failure detection of the liquid tank measuring system and the ability to continue operations post load cell failure detection.Type: GrantFiled: December 30, 2016Date of Patent: August 6, 2019Assignee: Air Liquide Electronics U.S. LPInventors: Bryan L. Smith, Mark Stang, Mike Miano, Billy W. Luetkahans, Daniel J. Fuchs, Matt Kelly, Bryon Perkins, Justin Gauthier, Kevin T. O'Dougherty
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Patent number: 9855589Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.Type: GrantFiled: April 6, 2015Date of Patent: January 2, 2018Assignee: Stratasys, Inc.Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
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Patent number: 9592539Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.Type: GrantFiled: January 5, 2011Date of Patent: March 14, 2017Assignee: Stratasys, Inc.Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
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Publication number: 20150209836Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.Type: ApplicationFiled: April 6, 2015Publication date: July 30, 2015Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
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Publication number: 20110186081Abstract: An automated support cleaning system comprising a tank disposed within a housing and configured to circulate an aqueous cleaning solution to remove a support structure from a three-dimensional model.Type: ApplicationFiled: January 5, 2011Publication date: August 4, 2011Applicant: STRATASYS, INC.Inventors: Benjamin N. Dunn, Thomas J. McDonough, Bryan L. Smith, William J. Swanson, James E. Orrock, Claudia Mosher, Randall R. Shay, Robert L. Skubic, Martin G. Zalusky, David M. Kozlak, Jerome W. Goetzke
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Patent number: 7376986Abstract: A collapsible bunk bed is provided having a first and second bed frame, one of which is positioned vertically above the other to form the bunk bed. The end walls of each bed frame have a hinged joint in the central portion so that the bunk bed may be folded into a collapsed configuration without disassembly of the end walls and side rails.Type: GrantFiled: October 19, 2006Date of Patent: May 27, 2008Assignee: Folding Bunk Properties (FBP), LLCInventors: Bryan L. Smith, Paulo Renato Zipperer, Frank Real