Patents by Inventor Bryan L. Spangelo

Bryan L. Spangelo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PT (IV) complexes containing 4,4?-disubstituted-2,2?-bipyridyl and their use in cancer therapy
    Patent number: 10316050
    Abstract: Platinum-containing compounds for the treatment of disease, such as, for example, cancer, are provided herein. Specifically, platinum Pt(IV) complexes with a substituted 2,2?-bipyridine ring structure are provided, as are methods for using the complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: June 11, 2019
    Assignee: The Board of Regents of the Nevada System of Higher Education on behalf of the University of Nevada, Las Vegas
    Inventors: Pradip K. Bhowmik, Bryan L. Spangelo, Van Vo, Haesook Han, Ontida Tanthmanatham
  • PT (IV) Complexes Containing 4,4'-Disubstituted-2,2'-Bipyridyl and Their Use in Cancer Therapy
    Publication number: 20170233423
    Abstract: Platinum-containing compounds for the treatment of disease, such as, for example, cancer, are provided herein. Specifically, platinum Pt(IV) complexes with a substituted 2,2?-bipyridine ring structure are provided, as are methods for using the complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: August 13, 2015
    Publication date: August 17, 2017
    Inventors: Pradip K. Bhowmik, Bryan L. Spangelo, Van Vo, Haesook Han, Ontida Tanthmanatham
  • Synthetic procedure and cancer treatment with cisplatin derivatives
    Patent number: 8703756
    Abstract: A method of reducing the in vivo viability of cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells has steps of: a) identifying a prospective patient having cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells; and b) administering a cisplatin derivative to the prospective patient so that the cisplatin derivative will contact the cancer cells; wherein the cisplatin derivative is a 4,4?-bis[RO]-2,2?-bipyridine)PtCl2 where, R is selected from the group consisting of —(CH2)nCH3 where n=2, 3, 4 or 5, and —(CH2)n[O(CH2)m]yO(CH2)zCH3 where n=2, m=2, y=2, z=1. A novel synthetic process for the manufacture of these compounds (and their analogs) is also provided.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: April 22, 2014
    Assignee: The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada, Las Vegas
    Inventors: Bryan L. Spangelo, Van Vo, Pradip K. Bhowmik, Ontida Tanthmanatham, Haesook Han
  • NOVEL SYNTHETIC PROCEDURE AND CANCER TREATMENT WITH CISPLATIN DERIVATIVES
    Publication number: 20130225546
    Abstract: A method of reducing the in vivo viability of cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells has steps of: a) identifying a prospective patient having cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells; and b) administering a cisplatin derivative to the prospective patient so that the cisplatin derivative will contact the cancer cells; wherein the cisplatin derivative is a 4,4?-bis[RO]-2,2?-bipyridine)PtCl2 where, R is selected from the group consisting of —(CH2)nCH3 where n=2, 3, 4 or 5, and —(CH2)n[O(CH2)m]yO(CH2)zCH3 where n=2, m=2, y=2, z=1. A novel synthetic process for the manufacture of these compounds (and their analogs) is also provided.
    Type: Application
    Filed: February 24, 2012
    Publication date: August 29, 2013
    Applicants: Neveda
    Inventors: Bryan L. Spangelo, Van Vo, Pradip K. Bhowmik, Ontida Tanthmanatham, Haesook Han