Patents by Inventor Bryan Laulicht
Bryan Laulicht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240088488Abstract: The present disclosure provides batteries that have a reduced risk or no risk of esophageal or gastrointestinal damage in a conductive aqueous environment, such as when accidentally swallowed. The batteries are, in some embodiments, nominally 9V, 3V or 1.5V coin or button cell-type batteries.Type: ApplicationFiled: November 20, 2023Publication date: March 14, 2024Applicant: Fenwood Labs Inc.Inventors: Bryan Laulicht, Jonah Myerberg, Ravikumar Vasudevan, Zachary Kelly
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Publication number: 20240085440Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface.Type: ApplicationFiled: November 17, 2023Publication date: March 14, 2024Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner
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Publication number: 20240014474Abstract: The present disclosure provides batteries that have a reduced risk or no risk of esophageal or gastrointestinal damage in a conductive aqueous environment, such as when accidentally swallowed. The batteries are, in some embodiments, nominally 9V, 3V or 1.5V coin or button cell-type batteries.Type: ApplicationFiled: August 24, 2021Publication date: January 11, 2024Applicant: Fenwood Labs Inc.Inventors: Bryan Laulicht, Jonah Myerberg, Ravikumar Vasudevan, Zachary Kelly
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Patent number: 11852639Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface.Type: GrantFiled: February 2, 2022Date of Patent: December 26, 2023Assignee: Perosphere Technologies Inc.Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner
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Publication number: 20220379044Abstract: An injection system comprising a syringe barrel; a first sealing element and a second sealing element moveably disposed in the syringe barrel; an injection chamber between them; a puncture element extending from the first sealing element to deliver an injection agent from the injection chamber into a biological space, wherein one or more of the syringe barrel, the first or the second sealing element are configured to prevent proximal movement of the first sealing element past a pre-selected location, while allowing the second sealing element to come in contact with the first sealing element, the system is configured such that, when a force is applied on the second sealing element in a distal direction, in response to a first opposing force, the puncture element advances and in response to a second opposing force, the puncture element remains stationary and the injection agent is conveyed through the puncture element.Type: ApplicationFiled: September 20, 2020Publication date: December 1, 2022Applicant: MeiraGTx Therapeutics, Inc.Inventors: Girish Chitnis, Jeff Karp, Edward Ahn, Bryan Laulicht
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Patent number: 11469465Abstract: The present disclosure provides batteries that have a reduced risk or no risk of esophageal or gastrointestinal damage in a conductive aqueous environment, such as when accidentally swallowed. The batteries are, in some embodiments, nominally 9V, 3V or 1.5V coin or button cell-type batteries.Type: GrantFiled: August 24, 2021Date of Patent: October 11, 2022Assignee: Fenwood Labs Inc.Inventors: Bryan Laulicht, Jonah Myerberg, Ravikumar Vasudevan, Zachary Kelly
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Publication number: 20220311109Abstract: The present disclosure provides batteries that have a reduced risk or no risk of gastrointestinal damage in a conductive aqueous environment, such as when accidentally swallowed. The batteries of the present disclosure advantageously stop producing significant current flow shortly after contact with a conductive aqueous medium, including the conductive aqueous medium of a wet tissue environment such as that found in the GI tract. The present disclosure further provides multi-layered laminate materials useful for manufacturing such batteries and methods for making the batteries. The batteries are, in some embodiments, 3 V or 1.5 V coin or button cell-type batteries.Type: ApplicationFiled: June 10, 2020Publication date: September 29, 2022Applicant: Fenwood Labs Inc.Inventors: Bryan Laulicht, Jonah Myerberg, Ravikumar Vasudevan, Zachary A. Kelly, Jeff M. Karp, Robert Langer
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Publication number: 20220155326Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface.Type: ApplicationFiled: February 2, 2022Publication date: May 19, 2022Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner
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Publication number: 20220069389Abstract: The present disclosure provides batteries that have a reduced risk or no risk of esophageal or gastrointestinal damage in a conductive aqueous environment, such as when accidentally swallowed. The batteries are, in some embodiments, nominally 9V, 3V or 1.5V coin or button cell-type batteries.Type: ApplicationFiled: August 24, 2021Publication date: March 3, 2022Applicant: Fenwood Labs Inc.Inventors: Bryan Laulicht, Jonah Myerberg, Ravikumar Vasudevan, Zachary Kelly
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Publication number: 20220069311Abstract: The present disclosure provides batteries that have a reduced risk or no risk of esophageal or gastrointestinal damage in a conductive aqueous environment, such as when accidentally swallowed. The batteries are, in some embodiments, nominally 9V, 3V or 1.5V coin or button cell-type batteries.Type: ApplicationFiled: August 24, 2021Publication date: March 3, 2022Applicant: Fenwood Labs Inc.Inventors: Bryan Laulicht, Jonah Myerberg, Ravikumar Vasudevan, Zachary Kelly
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Patent number: 11243219Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface.Type: GrantFiled: January 9, 2020Date of Patent: February 8, 2022Assignee: PEROSPHERE TECHNOLOGIES INC.Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner
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Patent number: 10868284Abstract: A battery for use in electronic devices and which is safely ingested into a body and a related method of making the battery. The battery includes an anode, a cathode and a quantum tunneling composite coating. The quantum tunneling composite coating covers at least a portion of at least one of the anode or the cathode and provides pressure sensitive conductive properties to the battery including a compressive stress threshold for conduction. The compressive stress threshold may be greater than a pre-determined applied stress in a digestive tract of the body in order to prevent harm if the battery is ingested. The battery may include a waterproof seal that extends between the quantum tunneling composite coating and a gasket separating the anode and cathode to inhibit the battery from short circuiting in a conductive fluid below the compressive stress threshold.Type: GrantFiled: July 8, 2019Date of Patent: December 15, 2020Assignees: The Brigham and Women's Hospital, Massachusetts Institute of TechnologyInventors: Bryan Laulicht, Janet Freilich, Jeffrey M. Karp, Robert Langer
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Publication number: 20200249247Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface.Type: ApplicationFiled: January 9, 2020Publication date: August 6, 2020Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner
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Patent number: 10682260Abstract: Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. A first adhesion level between the adhesive layer and the support layer is, or can be controlled to be, less than a second adhesion level between the adhesive layer and the substrate. The methods further include applying the adhesive tape to the substrate by contacting the adhesive layer to the substrate while the support layer remains in contact with the adhesive layer; and removing the support layer from the substrate by separating the support layer from the adhesive layer.Type: GrantFiled: March 5, 2018Date of Patent: June 16, 2020Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of TechnologyInventors: Bryan Laulicht, Jeffrey M. Karp, Robert S. Langer
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Publication number: 20200035961Abstract: A battery for use in electronic devices and which is safely ingested into a body and a related method of making the battery. The battery includes an anode, a cathode and a quantum tunneling composite coating. The quantum tunneling composite coating covers at least a portion of at least one of the anode or the cathode and provides pressure sensitive conductive properties to the battery including a compressive stress threshold for conduction. The compressive stress threshold may be greater than a pre-determined applied stress in a digestive tract of the body in order to prevent harm if the battery is ingested. The battery may include a waterproof seal that extends between the quantum tunneling composite coating and a gasket separating the anode and cathode to inhibit the battery from short circuiting in a conductive fluid below the compressive stress threshold.Type: ApplicationFiled: July 8, 2019Publication date: January 30, 2020Inventors: Bryan Laulicht, Janet Freilich, Jeffrey M. Karp, Robert Langer
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Patent number: 10534006Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface.Type: GrantFiled: March 1, 2018Date of Patent: January 14, 2020Assignee: Perosphere Technologies Inc.Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner
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Patent number: 10347875Abstract: A battery for use in electronic devices and which is safely ingested into a body and a related method of making the battery. The battery includes an anode, a cathode and a quantum tunneling composite coating. The quantum tunneling composite coating covers at least a portion of at least one of the anode or the cathode and provides pressure sensitive conductive properties to the battery including a compressive stress threshold for conduction. The compressive stress threshold may be greater than a pre-determined applied stress in a digestive tract of the body in order to prevent harm if the battery is ingested. The battery may include a waterproof seal that extends between the quantum tunneling composite coating and a gasket separating the anode and cathode to inhibit the battery from short circuiting in a conductive fluid below the compressive stress threshold.Type: GrantFiled: July 21, 2017Date of Patent: July 9, 2019Assignees: Massachusetts Institute of Technology, The Brigham and Women's HospitalInventors: Bryan Laulicht, Janet Freilich, Jeffrey M. Karp, Robert Langer
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Patent number: 10201655Abstract: An apparatus provides targeted placement of openings for infusing fluids into a body. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus due to contraction of an element made of interlaced flexible elements. A multi-opening needle is provided in some embodiments wherein placement of one of the openings in a target region with a relatively lower external pressure allows pressurized fluid to exit the needle while openings remaining in higher pressure, non-target regions do not release substantial amounts of the fluid.Type: GrantFiled: August 7, 2013Date of Patent: February 12, 2019Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of TechnologyInventors: Eoin D. O'Cearbhaill, Bryan Laulicht, Alexander H. Slocum, Robert S. Langer, Omid C. Farokhzad, Jeffrey M. Karp
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Publication number: 20180360668Abstract: Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. A first adhesion level between the adhesive layer and the support layer is, or can be controlled to be, less than a second adhesion level between the adhesive layer and the substrate. The methods further include applying the adhesive tape to the substrate by contacting the adhesive layer to the substrate while the support layer remains in contact with the adhesive layer; and removing the support layer from the substrate by separating the support layer from the adhesive layer.Type: ApplicationFiled: March 5, 2018Publication date: December 20, 2018Inventors: Bryan Laulicht, Jeffrey M. Karp, Robert S. Langer
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Patent number: D964569Type: GrantFiled: December 18, 2019Date of Patent: September 20, 2022Assignee: PEROSPHERE TECHNOLOGIES INC.Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner