Patents by Inventor Bryan M. Lewis

Bryan M. Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods useful in the synthesis of halichondrin B analogs
    Patent number: 10450324
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: October 22, 2019
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
  • METHODS OF TREATING A NEURODEGENERATIVE DISEASE
    Publication number: 20190111052
    Abstract: The present application relates to new uses of 5-HT6 receptor antagonists, specifically high doses of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, and to the combination of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, with, an acetylcholinesterase inhibitor for the treatment of a neurodegenerative disease.
    Type: Application
    Filed: July 19, 2018
    Publication date: April 18, 2019
    Inventors: Lawrence Tim FRIEDHOFF, Stephen Clement PISCITELLI, Kunal KISHNANI, Shankar RAMASWAMY, Bryan M. LEWIS
  • METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20190010166
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: July 10, 2018
    Publication date: January 10, 2019
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Methods useful in the synthesis of halichondrin B analogs
    Patent number: 10030032
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 24, 2018
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
  • COMPOSITIONS AND METHODS OF TREATING A NEURODEGENERATIVE DISEASE
    Publication number: 20180042922
    Abstract: The present application relates to novel compositions useful for the treatment of a neurodegenerative disease and uses thereof. The present application also relates to novel compositions and methods for the reduction of side effects in a subject being treated for a neurodegenerative disease. The present application also relates to novel compositions and methods for enhancing the standard of care of the treatment of a neurodegenerative disease. The present application also relates to novel compositions and methods for enhancing the efficacy of one or more treatments for a neurodegenerative disease.
    Type: Application
    Filed: August 15, 2017
    Publication date: February 15, 2018
    Inventors: Pavan Kumar CHERUVU, Kunal KISHNANI, Bryan M. LEWIS, Stephen Clement PISCITELLI, Shankar RAMASWAMY, Gregory M. WEINHOFF, Ebenezer ASARE
  • METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20170298078
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: June 30, 2017
    Publication date: October 19, 2017
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Methods useful in the synthesis of halichondrin B analogs
    Patent number: 9695188
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: July 4, 2017
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
  • METHODS OF TREATING A NEURODEGENERATIVE DISEASE
    Publication number: 20160324851
    Abstract: The present application relates to new uses of 5-HT6 receptor antagonists, specifically high doses of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, and to the combination of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline, with, an acetylcholinesterase inhibitor for the treatment of a neurodegenerative disease.
    Type: Application
    Filed: May 6, 2016
    Publication date: November 10, 2016
    Inventors: Lawrence Tim FRIEDHOFF, Stephen Clement PISCITELLI, Kunal KISHNANI, Shankar RAMASWAMY, Bryan M. LEWIS
  • COMPOSITIONS AND METHODS OF TREATING A NEURODEGENERATIVE DISEASE
    Publication number: 20160324852
    Abstract: The present application relates to new uses of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or pharmaceutically acceptable salts, hydrates, solvates, or polymorphs, thereof, and to the combination of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or pharmaceutically acceptable salts, hydrates, solvates, or polymorphs, thereof, with other therapeutic agents for the treatment of a neurodegenerative disease.
    Type: Application
    Filed: May 6, 2016
    Publication date: November 10, 2016
    Inventors: Lawrence Tim FRIEDHOFF, Melissa RHODES, Stephen Clement PISCITELLI, Kunal KISHNANI, Shankar RAMASWAMY, Bryan M. LEWIS, Geetha RAMASWAMY
  • METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20160176895
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: March 3, 2016
    Publication date: June 23, 2016
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Methods useful in the synthesis of halichondrin B analogs
    Patent number: 9303039
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 5, 2016
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Huiming Zhang, Bryan M. Lewis
  • METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20150158881
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: December 5, 2014
    Publication date: June 11, 2015
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Intermediates for the preparation of analogs of halichondrin B
    Patent number: 8975422
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: March 10, 2015
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, Bryan M. Lewis, Matthew Schnaderbeck
  • INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B
    Publication number: 20140221635
    Abstract: Intermediates and methods of their use in the synthesis of anslogs of halichondrin B are provided.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. FANG, Bryan M. LEWIS, Matthew SCHNADERBECK
  • INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B
    Publication number: 20120029213
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Application
    Filed: June 29, 2011
    Publication date: February 2, 2012
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Brian Austad, Farid Benayoud, Trevor Calkins, Silvio Campagna, Charles E. Chase, William Christ, Francis G. Fang, Yongbo Hu, Bryan M. Lewis, Marc Pesant, Matthew Schnaderbeck, Gordon Wilkie, Xiaojie Zhu
  • Intermediates for the preparation of analogs of Halichondrin B
    Patent number: RE46965
    Abstract: The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: July 24, 2018
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Brian Austad, Charles E. Chase, Francis G. Fang, Trevor Calkins, Bryan M. Lewis
  • Intermediates for the preparation of analogs of halichondrin B
    Patent number: RE47797
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: January 7, 2020
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Farid Benayoud, Trevor Lee Calkins, Charles E. Chase, William Christ, Bryan M. Lewis, Matthew Schnaderbeck, Marc Pesant, Brian Austad, Silvio Campagna, Yongbo Hu, Gordon Wilkie, Xiaojie Zhu, Francis G. Fang