Patents by Inventor Bryan M. O'Hara

Bryan M. O'Hara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel compounds that enhance dimerization of the subunits of HIV-1 reverse transcriptase having mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors
    Publication number: 20030109468
    Abstract: The invention provides novel compounds that enhance dimerization of the subunits of HIV-1 reverse transcriptase having mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs). Such compounds inhibit HIV-1 reverse transcriptase activity and as such, inhibit HIV-1, in particular HIV-1 resistant to conventional NNRTIs. The invention provides a method of determining whether a compound enhances formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase, in which the p66 subunit has at least one or more mutations associated with resistance of HIV-1 to at least one NNRTI. The invention further provides methods of using a compound that enhances formation of a complex between a p66 subunit polypeptide having at least one mutation associated with resistance of HIV-1 to at least one NNRTI and a p51 subunit of HIV-1 reverse transcriptase.
    Type: Application
    Filed: December 6, 2001
    Publication date: June 12, 2003
    Inventor: Bryan M. O' Hara
  • Triazine containing anionic compounds useful as antiviral agents
    Patent number: 5852015
    Abstract: This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: December 22, 1998
    Assignee: American Cyanamid Company
    Inventors: Yakov Gluzman, deceased, James P. LaRocque, Bryan M. O'Hara, John E. Morin, George A. Ellestad, Boris Mitsner, Wei-Dong Ding, Yuri E. Raifeld, Antonina A. Nikitenko
  • Amphotropic virus receptor
    Patent number: 5633348
    Abstract: The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding for Gibbon Ape Leukemia Virus (GALV). Differences for the type of retroviruses interacting with the receptors exist. The protein encoding by the GLVR2 gene, cells transformed or transfected by the gene and vectors containing the gene are also disclosed.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: May 27, 1997
    Assignee: American Cyanamid Company
    Inventors: Stephen V. Johann, Marja van Zeijl, Bryan M. O'Hara
  • Nucleic acid molecule encoding the amphotropic virus receptor
    Patent number: 5550221
    Abstract: The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding Gibbon Ape Leukemia Virus (GALV) receptor. Differences in the type of retroviruses interacting with the receptors exist. The protein encoded by the GLVR2, cells transformed or transfected by the gene, and vectors containing the gene are also disclosed.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: August 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Stephen V. Johann, Marja van Zeijl, Bryan M. O'Hara
  • DNA encoding gibbon ape leukemia virus receptor
    Patent number: 5414076
    Abstract: The present invention relates to the gibbon ape leukemia virus (GALV) receptor protein and gene, as well as methods for regulating viral entry into cells.
    Type: Grant
    Filed: March 25, 1991
    Date of Patent: May 9, 1995
    Assignee: American Cyanamid Company
    Inventor: Bryan M. O'Hara
  • Host cells expressing gibbon ape leukemia virus receptor
    Patent number: 5151361
    Abstract: The present invention relates to novel purified gibbon ape leukemia receptor proteins and purified DNA sequences encoding these receptor proteins. The invention also relates to a method for identifying receptor proteins using the isolated DNA sequence as a probe, and a method for regulating viral entry into cells by manipulation of the GALV receptor.
    Type: Grant
    Filed: March 25, 1991
    Date of Patent: September 29, 1992
    Assignee: American Cyanamid Company
    Inventor: Bryan M. O'Hara