Abstract: A tubular joint includes a tubular substrate extending along an axis. The substrate has a first inner diameter. A first tubular brace member is additively manufactured on the substrate and is connected thereto at a proximal end of the first tubular brace member. A second tubular brace member is additively manufactured on the substrate and is connected thereto at a proximal end of the second tubular brace member. At respective distal ends of the brace members, the first tubular brace member and the second tubular brace member have a circular cross-sectional shape having a distal wall thickness and a second inner diameter that is smaller than the first inner diameter. At the proximal ends the of brace members, the first tubular brace member and the second tubular brace member have respective proximal wall thicknesses that are greater than the distal wall thickness.

Abstract: The disclosed technology relates generally to welding technologies and more particularly to electrode assemblies for arc welding, e.g., submerged arc welding. In one aspect, an electrode assembly for submerged arc welding (SAW), the electrode assembly comprising a head portion comprising a contact nozzle and an extension portion removably and serially attached to the contact nozzle and disposed to be proximal to an arcing tip of a consumable electrode relative to the contact nozzle. The extension portion comprises a ceramic sleeve configured to slidingly feed the consumable electrode therethrough, and a pair of metallic sheaths covering opposing ends of the ceramic sleeve.

Abstract: The disclosed technology relates generally to welding technologies and more particularly to electrode assemblies for arc welding, e.g., submerged arc welding. In one aspect, an electrode assembly for submerged arc welding (SAW) comprises a head portion and an extension portion that are arranged serially to feed a consumable electrode therethrough such that, during SAW, the head portion is disposed to be distal to an arcing tip of the consumable electrode and the extension portion is disposed to be proximal to the arcing tip of the consumable electrode. The head portion includes a contact tip configured to electrically contact the consumable electrode to deliver power thereto. The extension portion is formed of a single piece insulating article configured for the consumable electrode to finally pass through before the arcing tip is exposed.

Abstract: The disclosed technology generally relates to welding technologies and more particularly to electrode assemblies for arc welding, e.g., submerged arc welding. In one aspect, an electrode assembly for submerged arc welding comprises a contact tip portion and an extension portion arranged serially and configured to feed a consumable electrode therethrough. During welding, the contact tip portion is disposed to be distal to an arcing tip of the consumable electrode and the extension portion is disposed to be proximal to the arcing tip of the consumable electrode. The extension portion is configured to electrically insulate the consumable electrode from a work piece during welding with a solid insulating material surrounding the consumable electrode.

Abstract: A tubular joint includes a tubular substrate extending along an axis. The substrate has a first inner diameter. A first tubular brace member is additively manufactured on the substrate and is connected thereto at a proximal end of the first tubular brace member. A second tubular brace member is additively manufactured on the substrate and is connected thereto at a proximal end of the second tubular brace member. At respective distal ends of the brace members, the first tubular brace member and the second tubular brace member have a circular cross-sectional shape having a distal wall thickness and a second inner diameter that is smaller than the first inner diameter. At the proximal ends the of brace members, the first tubular brace member and the second tubular brace member have respective proximal wall thicknesses that are greater than the distal wall thickness.

Abstract: In various embodiments, systems load primary drug containers into a processing apparatus in which the containers are automatically scanned for label information, sanitized, pierced, and their liquid contents aspirated out into a secondary container, such as a reservoir bag. A filtration process (e.g., a 0.2 ?m filtration process) may be performed during this process, or the liquid may first be loaded into an intermediate container and filtered during transfer into another container (e.g., a second reservoir bag).

Abstract: The invention provides novel compounds that enhance dimerization of the subunits of HIV-1 reverse transcriptase having mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs). Such compounds inhibit HIV-1 reverse transcriptase activity and as such, inhibit HIV-1, in particular HIV-1 resistant to conventional NNRTIs. The invention provides a method of determining whether a compound enhances formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase, in which the p66 subunit has at least one or more mutations associated with resistance of HIV-1 to at least one NNRTI. The invention further provides methods of using a compound that enhances formation of a complex between a p66 subunit polypeptide having at least one mutation associated with resistance of HIV-1 to at least one NNRTI and a p51 subunit of HIV-1 reverse transcriptase.

Abstract: This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding for Gibbon Ape Leukemia Virus (GALV). Differences for the type of retroviruses interacting with the receptors exist. The protein encoding by the GLVR2 gene, cells transformed or transfected by the gene and vectors containing the gene are also disclosed.

Abstract: The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding Gibbon Ape Leukemia Virus (GALV) receptor. Differences in the type of retroviruses interacting with the receptors exist. The protein encoded by the GLVR2, cells transformed or transfected by the gene, and vectors containing the gene are also disclosed.

Abstract: The present invention relates to the gibbon ape leukemia virus (GALV) receptor protein and gene, as well as methods for regulating viral entry into cells.

Abstract: The present invention relates to novel purified gibbon ape leukemia receptor proteins and purified DNA sequences encoding these receptor proteins. The invention also relates to a method for identifying receptor proteins using the isolated DNA sequence as a probe, and a method for regulating viral entry into cells by manipulation of the GALV receptor.