Patents by Inventor Bryan P. Fox
Bryan P. Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8962796Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.Type: GrantFiled: January 31, 2013Date of Patent: February 24, 2015Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogentanz
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Publication number: 20140329309Abstract: The present invention provides methods and compositions of improved expression systems in microorganisms. The methods and compositions comprise a ribosomal promoter derived from a Bacillus species microorganism, such a ribosomal RNA or a ribosomal protein promoter.Type: ApplicationFiled: December 6, 2012Publication date: November 6, 2014Inventors: Cristina Bongiorni, Bryan P. Fox, Anita van Kimmenade
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Patent number: 8394941Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.Type: GrantFiled: April 8, 2011Date of Patent: March 12, 2013Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Publication number: 20110256608Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.Type: ApplicationFiled: April 8, 2011Publication date: October 20, 2011Applicant: Danisco US Inc.Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Publication number: 20110201535Abstract: Streptomyces and Bacillus host cells comprising a recombinant nucleic acid encoding a fusion protein containing a signal sequence and a Streptomyces subtilisin inhibitor (SSI) protein are provided, as well as methods of producing SSI protein using those cells. In certain embodiments, the host cell is a Streptomyces host cell and the signal to sequence is a celA signal sequence. In other embodiments, the host cell is a Bacillus host cell has a genome that contains inactivated protease genes.Type: ApplicationFiled: April 20, 2011Publication date: August 18, 2011Applicant: DANISCO US INC.Inventors: Bryan P. Fox, Huaming Wang
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Patent number: 7947475Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.Type: GrantFiled: May 13, 2010Date of Patent: May 24, 2011Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Patent number: 7803902Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.Type: GrantFiled: October 15, 2008Date of Patent: September 28, 2010Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Publication number: 20100221780Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.Type: ApplicationFiled: May 13, 2010Publication date: September 2, 2010Applicant: DANISCO US INC.Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Patent number: 7772181Abstract: The present invention relates to compositions that comprise modified variant Bowman Birk Protease Inhibitor proteins (BBPIs). The modified variant BBPIs comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses the compositions comprising the modified variant BBPIs, and the methods for making and using the compositions in personal care.Type: GrantFiled: October 15, 2008Date of Patent: August 10, 2010Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Publication number: 20100092409Abstract: The present invention relates to compositions that comprise modified variant Bowman Birk Protease Inhibitor proteins (BBPIs). The modified variant BBPIs comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses the compositions comprising the modified variant BBPIs, and the methods for making and using the compositions in personal care.Type: ApplicationFiled: October 15, 2008Publication date: April 15, 2010Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Publication number: 20100093028Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.Type: ApplicationFiled: October 15, 2008Publication date: April 15, 2010Inventors: Neelam S. Amin, Katherine D. Collier, Melodie Estabrook, David A. Estell, Bryan P. Fox, Scott D. Power, Brian F. Schmidt, Gudrun Vogtentanz
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Publication number: 20080090745Abstract: Streptomyces and Bacillus host cells comprising a recombinant nucleic acid encoding a fusion protein containing a signal sequence and a Streptomyces subtilisin inhibitor (SSI) protein are provided, as well as methods of producing SSI protein using those cells. In certain embodiments, the host cell is a Streptomyces host cell and the signal sequence is a celA signal sequence. In other embodiments, the host cell is a Bacillus host cell has a genome that contains inactivated protease genes.Type: ApplicationFiled: October 13, 2006Publication date: April 17, 2008Inventors: Bryan P. Fox, Huaming Wang