Patents by Inventor Bryan Paeper

Bryan Paeper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for increasing bone mineralization
    Patent number: 7572899
    Abstract: Nucleic acids relating to human TGF-? binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: August 11, 2009
    Assignee: UCB SA
    Inventors: Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan Paeper, Jeffrey Van Ness, David G Winkler
  • Compositions and methods for increasing bone mineralization
    Publication number: 20060233801
    Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: April 5, 2006
    Publication date: October 19, 2006
    Inventors: Mary Brunkow, David Galas, Brian Kovacevich, John Mulligan, Bryan Paeper, Jeffrey Ness, David Winkler
  • Compositions and methods for increasing bone mineralization
    Publication number: 20040058321
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: March 7, 2002
    Publication date: March 25, 2004
    Applicant: Darwin Discovery Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan Paeper, Jeffrey Van Ness, David G. Winkler
  • Methods for identifying genomic deletions
    Patent number: 6475739
    Abstract: The genomic locus responsible for Van Buchem's disease is narrowed to an approximately 92 kb region of human chromosome 17 at 17q21. Individuals afflicted with or carriers of Van Buchem's disease exhibit a 52 kb deletion within this 92 kb region. Methods are provided that permit the differentiation between individuals homozygous for and therefore afflicted with Van Buchem's disease, individuals heterozygous for and therefore carriers of Van Buchem's disease, and individuals who are normal with respect to Van Buchem's disease. Also provided are general methodologies for the detection of a wide variety of large genomic deletions.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: November 5, 2002
    Assignee: Celltech R&D, Inc.
    Inventors: Mary E. Brunkow, Sean Proll, Bryan Paeper, Karen Staehling-Hampton
  • Methods for identifying genomic deletions
    Publication number: 20020076720
    Abstract: The genomic locus responsible for Van Buchem's disease is narrowed to an approximately 92 kb region of human chromosome 17 at 17q21. Individuals afflicted with or carriers of Van Buchem's disease exhibit a 52 kb deletion within this 92 kb region. Methods are provided that permit the differentiation between individuals homozygous for and therefore afflicted with Van Buchem's disease, individuals heterozygous for and therefore carriers of Van Buchem's disease, and individuals who are normal with respect to Van Buchem's disease. Also provided are general methodologies for the detection of a wide variety of large genomic deletions.
    Type: Application
    Filed: July 30, 2001
    Publication date: June 20, 2002
    Inventors: Mary E. Brunkow, Sean Proll, Bryan Paeper, Karen Staehling-Hampton