Patents by Inventor Bryan R. Becklund

Bryan R. Becklund has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses Thereof
    Publication number: 20250109203
    Abstract: Provided herein are polypeptides comprising at least one VHH domain that binds ?? TCR and a modified IL-2. Uses of the polypeptides are also provided.
    Type: Application
    Filed: January 4, 2023
    Publication date: April 3, 2025
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: Bryan R. Becklund, Kyle S. Jones, Kaitlyn N. Robinson, Andrew M. Eckles, John C. Timmer, Brendan P. Eckelman
  • Gamma Delta T-Cell-Binding Polypeptides and Uses Thereof
    Publication number: 20250066477
    Abstract: Provided herein are VHH-containing polypeptides that bind ?? T-cells. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: January 4, 2023
    Publication date: February 27, 2025
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: Bryan R. Becklund, Kyle S. Jones, Kaitlyn N. Robinson, Andrew M. Eckles, John C. Timmer, Brendan P. Eckelman
  • IgE binding proteins and uses thereof
    Patent number: 12234297
    Abstract: Provided herein are IgE-binding VHH domains, polypeptides, and proteins, and methods of using such IgE-binding polypeptides and proteins to modulate the biological activity of IgE.
    Type: Grant
    Filed: August 2, 2024
    Date of Patent: February 25, 2025
    Assignees: Phylaxis Bioscience, LLC, Inhibrx Biosciences, Inc.
    Inventors: Bryan R. Becklund, Kyle S. Jones, Andrew M. Eckles, Brendan P. Eckelman, Tony Dung-Ling Yao
  • IgE BINDING PROTEINS AND USES THEREOF
    Publication number: 20250019464
    Abstract: Provided herein are IgE-binding VHH domains, polypeptides, and proteins, and methods of using such IgE-binding polypeptides and proteins to modulate the biological activity of IgE.
    Type: Application
    Filed: August 2, 2024
    Publication date: January 16, 2025
    Inventors: Bryan R. Becklund, Kyle S. Jones, Andrew M. Eckles, Brendan P. Eckelman, Tony Dung-Ling Yao
  • Polypeptides Comprising Modified IL-2 Polypeptides and Uses Thereof
    Publication number: 20230235005
    Abstract: Provided herein are polypeptide comprising a modified IL-2, wherein the modified IL-2 has reduced affinity for the IL-2 receptor relative to wild type IL-2. In some embodiments, polypeptides comprising a modified IL-2 that bind and agonize activated T cells are provided. Uses of the polypeptides comprising a modified IL-2 are also provided.
    Type: Application
    Filed: July 1, 2021
    Publication date: July 27, 2023
    Applicant: Inhibrx, Inc.
    Inventors: John C. Timmer, Florian Sulzmaier, Katelyn M. Willis, Bryan R. Becklund, Brendan P. Eckelman
  • Polypeptides Comprising Modified IL-2 Polypeptides and Uses Thereof
    Publication number: 20220089667
    Abstract: Provided herein are polypeptide comprising a modified IL-2, wherein the modified IL-2 has reduced affinity for the IL-2 receptor relative to wild type IL-2. In some embodiments, polypeptides comprising a modified IL-2 that bind and agonize activated T cells are provided. Uses of the polypeptides comprising a modified IL-2 are also provided.
    Type: Application
    Filed: January 6, 2020
    Publication date: March 24, 2022
    Applicant: Inhibrx, Inc.
    Inventors: John C. Timmer, Brendan P. Eckelman, Katelyn McKabe Willis, Florian J. Sulzmaier, Bryan R. Becklund
  • Method of treating multiple sclerosis
    Patent number: 11260241
    Abstract: A method and computer program product for suppressing the symptoms of multiple sclerosis (MS) by irradiating a subject exhibiting the symptoms with a pre-determined dose of UV-containing light from a light source and detecting a suppression of the clinical symptoms of MS. In particular, the detected suppression of the clinical symptoms is disassociated from the vitamin D production within the subject.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: March 1, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Hector F. Deluca, Bryan R. Becklund
  • METHOD OF TREATING MULTIPLE SCLEROSIS
    Publication number: 20190381335
    Abstract: A method and computer program product for suppressing the symptoms of multiple sclerosis (MS) by irradiating a subject exhibiting the symptoms with a pre-determined dose of UV-containing light from a light source and detecting a suppression of the clinical symptoms of MS. In particular, the detected suppression of the clinical symptoms is disassociated from the vitamin D production within the subject.
    Type: Application
    Filed: September 14, 2018
    Publication date: December 19, 2019
    Inventors: Hector F. Deluca, Bryan R. Becklund
  • METHOD OF TREATING MULTIPLE SCLEROSIS
    Publication number: 20190009104
    Abstract: A method and computer program product for suppressing the symptoms of multiple sclerosis (MS) by irradiating a subject exhibiting the symptoms with a pre-determined dose of UV-containing light from a light source and detecting a suppression of the clinical symptoms of MS. In particular, the detected suppression of the clinical symptoms is disassociated from the vitamin D production within the subject.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 10, 2019
    Inventors: Hector F. Deluca, Bryan R. Becklund
  • METHOD OF TREATING MULTIPLE SCLEROSIS
    Publication number: 20130073009
    Abstract: A method and computer program product for suppressing the symptoms of multiple sclerosis (MS) by irradiating a subject exhibiting the symptoms with a predetermined dose of UV-containing light from a light source and detecting a suppression of the clinical symptoms of MS. In particular, the detected suppression of the clinical symptoms is disassociated from the vitamin D production within the subject.
    Type: Application
    Filed: February 3, 2011
    Publication date: March 21, 2013
    Inventors: Hector F. Deluca, Bryan R. Becklund
  • Use of calcitonin and calcitonin-like peptides to treat and prevent multiple sclerosis
    Patent number: 7745404
    Abstract: Methods for treating and preventing multiple sclerosis by administering to a patient an effective amount of calcitonin, calcitonin-like peptides or calcitonin mimetics to a patient. Additionally, 1,25-dihydroxyvitamin D analogs can be used in combination with the calcitonin, calcitonin-like peptides or calcitonin mimetics.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: June 29, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Terrence F. Meehan, Bryan R. Becklund, Margaret Clagett-Dame
  • Use of calcitonin and calcitonin-like peptides to treat and prevent multiple sclerosis
    Patent number: 7566696
    Abstract: Methods for treating and preventing multiple sclerosis by administering to a patient an effective amount of calcitonin, calcitonin-like peptides or calcitonin mimetics to a patient. Additionally, 1,25-dihydroxyvitamin D analogs can be used in combination with the calcitonin, calcitonin-like peptides or calcitonin mimetics.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: July 28, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Terrence F. Meehan, Bryan R. Becklund, Margaret Clagett-Dame
  • USE OF CALCITONIN AND CALCITONIN-LIKE PEPTIDES TO TREAT AND PREVENT MULTIPLE SCLEROSIS
    Publication number: 20080146491
    Abstract: Methods for treating and preventing multiple sclerosis by administering to a patient an effective amount of calcitonin, calcitonin-like peptides or calcitonin mimetics to a patient. Additionally, 1,25-dihydroxyvitamin D analogs can be used in combination with the calcitonin, calcitonin-like peptides or calcitonin mimetics.
    Type: Application
    Filed: December 7, 2007
    Publication date: June 19, 2008
    Inventors: Hector F. DeLuca, Terrence F. Meehan, Bryan R. Becklund, Margaret Clagett-Dame