Patents by Inventor Bryan S. Margulies

Bryan S. Margulies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlled release formulation and minimally invasive method of administration to locally treat cancer
    Patent number: 11957676
    Abstract: A controlled release formulation comprising an opioid growth factor receptor (OGFR) antagonist and at least one pharmaceutically acceptable carrier has been developed, which is useful for treating cancer when locally administered at a disease site.
    Type: Grant
    Filed: August 7, 2023
    Date of Patent: April 16, 2024
    Assignee: Zetagen Therapeutics, Inc.
    Inventor: Bryan S. Margulies
  • METHODS AND COMPOSITIONS TO GRAFT BONE USING IRON EXCIPIENTS
    Publication number: 20240016976
    Abstract: A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.
    Type: Application
    Filed: September 6, 2023
    Publication date: January 18, 2024
    Applicant: Zetagen Therapeutics, Inc.
    Inventors: Bryan S. Margulies, Nikhil A. Thakur
  • METHODS AND COMPOSITIONS TO GRAFT BONE USING IRON EXCIPIENTS
    Publication number: 20240000996
    Abstract: A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.
    Type: Application
    Filed: September 7, 2023
    Publication date: January 4, 2024
    Applicant: Zetagen Therapeutics, Inc.
    Inventors: Bryan S. Margulies, Nikhil A. Thakur
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20230190733
    Abstract: This disclosure relates to methods and compositions for treating cancer by administering opioid growth factor receptor (OGFR) antagonists. In particular, the present disclosure relates to methods of administering OGFR antagonists locally to the site of cancer cells in the patient diagnosed with cancer.
    Type: Application
    Filed: October 17, 2022
    Publication date: June 22, 2023
    Applicant: Zetagen Therapeutics, Inc.
    Inventors: Bryan S. Margulies, Nikhil A. Thakur
  • Methods and compositions for treating cancer
    Patent number: 11471454
    Abstract: This disclosure relates to methods and compositions for treating cancer by administering opioid growth factor receptor (OGFR) antagonists. In particular, the present disclosure relates to methods of administering OGFR antagonists locally to the site of cancer cells in the patient diagnosed with cancer.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: October 18, 2022
    Assignee: Zetagen Therapeutics, Inc.
    Inventors: Bryan S. Margulies, Nikhil A. Thakur
  • Neurogenic regulation of bone growth and bone degradation
    Patent number: 11253628
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSCs) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteopetrosis or osteoradionecrosis.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: February 22, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Bryan S. Margulies, Sean D. Deboyace
  • METHODS AND COMPOSITIONS TO GRAFT BONE USING IRON EXCIPIENTS
    Publication number: 20220016312
    Abstract: A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.
    Type: Application
    Filed: January 7, 2021
    Publication date: January 20, 2022
    Applicant: Zetagen Therapeutics, Inc.
    Inventors: Bryan S. Margulies, Nikhil A. Thakur
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20210228571
    Abstract: This disclosure relates to methods and compositions for treating cancer by administering opioid growth factor receptor (OGFR) antagonists. In particular, the present disclosure relates to methods of administering OGFR antagonists locally to the site of cancer cells in the patient diagnosed with cancer.
    Type: Application
    Filed: March 31, 2021
    Publication date: July 29, 2021
    Applicant: Rovaxa
    Inventors: Bryan S. Margulies, Nikhil A. Thakur
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20210030746
    Abstract: This disclosure relates to methods and compositions for treating cancer by administering opioid growth factor receptor (OGFR) antagonists. In particular, the present disclosure relates to methods of administering OGFR antagonists locally to the site of cancer cells in the patient diagnosed with cancer.
    Type: Application
    Filed: July 14, 2020
    Publication date: February 4, 2021
    Applicant: Rovaxa
    Inventors: Bryan S. Margulies, Nikhil A. Thakur
  • NEUROGENIC REGULATION OF BONE GROWTH AND BONE DEGRADATION
    Publication number: 20190307918
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSCs) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteopetrosis or osteoradionecrosis.
    Type: Application
    Filed: April 19, 2019
    Publication date: October 10, 2019
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Bryan S. MARGULIES, Sean D. DEBOYACE
  • Neurogenic regulation of bone growth and bone degradation
    Patent number: 10265437
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSCs) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteopetrosis or osteoradionecrosis.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: April 23, 2019
    Assignee: The Research Foundation for the State University of New York
    Inventors: Bryan S. Margulies, Sean D. Deboyace
  • COMPOSITIONS AND METHODS TO PROMOTE BONE FORMATION
    Publication number: 20190093109
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis.
    Type: Application
    Filed: September 4, 2018
    Publication date: March 28, 2019
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Nikhil A. Thakur, Bryan S. Margulies
  • Compositions and methods to promote bone formation
    Patent number: 10208306
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 19, 2019
    Assignee: The Research Foundation for the State University of New York
    Inventors: Nikhil A. Thakur, Bryan S. Margulies
  • NEUROGENIC REGULATION OF BONE GROWTH AND BONE DEGRADATION
    Publication number: 20170000926
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSCs) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteopetrosis or osteoradionecrosis.
    Type: Application
    Filed: March 13, 2015
    Publication date: January 5, 2017
    Inventors: Bryan S. MARGULIES, Sean D. DEBOYACE
  • COMPOSITIONS AND METHODS TO PROMOTE BONE FORMATION
    Publication number: 20150344882
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 3, 2015
    Inventors: Nikhil A. Thakur, Bryan S. Margulies