Patents by Inventor Bryan Simard

Bryan Simard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid Based Nanoparticles for Targeted Gene Delivery to the Brain
    Publication number: 20250222129
    Abstract: The present document describes a pharmaceutical composition comprising a) a lipid nanoparticle operable to encapsulate a therapeutic agent, comprising a core and an external surface, said therapeutic agent being encapsulated within said core; said lipid nanoparticle having a size of said lipid nanoparticle of from about 30 to about 80 nm, or a pegylated lipid comprising a distearoyl-rac-glycerol (DSG)-PEG and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(DSPE)-PEG-DBCO; or a combination of: a size of from about 30 to about 80 nm and a pegylated lipid comprising a DSG-PEG and DSPE-PEG-DBCO; and b) an antibody or antigen-binding fragment thereof operable to transmigrate the blood-brain barrier (BBB), wherein the antibody or antigen-binding fragment thereof comprises complementarity determining regions (CDR1, CDR2 and CDR3), operably linked to said external surface of said lipid nanoparticle.
    Type: Application
    Filed: March 21, 2023
    Publication date: July 10, 2025
    Applicant: National Research Council of Canada
    Inventors: Abedelnasser Abulrob, Danica Stanimirovic, Umar Iqbal, Bryan Simard, Michel Gilbert, Yves Durocher, Warren Wakarchuk
  • Methods for administration of a farnesyl dibenzodiazepinone
    Patent number: 7763604
    Abstract: This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms by administration of the farnesylated dibenzodiazepinone compound of Formula I via continuous intravenous infusion.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: July 27, 2010
    Assignee: Thallion Pharma Ceuticals, Inc.
    Inventors: Henriette Gourdeau, Maxime Ranger, François Berger, Bryan Simard
  • Methods for administration of a farnesyl dibenzodiazepinone
    Publication number: 20060270662
    Abstract: This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms by administration of the farnesylated dibenzodiazepinone compound of Formula I via continuous intravenous infusion.
    Type: Application
    Filed: May 16, 2006
    Publication date: November 30, 2006
    Inventors: Henriette Gourdeau, Maxime Ranger, Francois Berger, Bryan Simard