Abstract: Provided herein are compounds of Formula I and their salts, and compositions thereof that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) and/or acetylcholinesterase (AChE) in cells. Also disclosed herein are methods of using the disclosed compounds and compositions for inhibiting the spread of Tau seeds from donor cells to recipient cells. Further disclosed herein are methods of using the disclosed compounds and compositions for treating or preventing a neurodegenerative disorder, such as a tauopathy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).

Abstract: In an example embodiment, there is described herein an method comprising a cassette operable to store documents, the cassette having an external surface, an electrophoretic display coupled with the external surface, and a wireless interface coupled with the cassette and operably coupled with the electrophoretic display. In particular embodiments, the electrophoretic display is operable to receive data representative of configuration from a wireless device in data communication with the wireless interface.

Abstract: In an example embodiment, there is described herein an method comprising a cassette operable to store documents, the cassette having an external surface, an electrophoretic display coupled with the external surface, and a wireless interface coupled with the cassette and operably coupled with the electrophoretic display. In particular embodiments, the electrophoretic display is operable to receive data representative of configuration from a wireless device in data communication with the wireless interface.

Abstract: In an example embodiment, there is described herein an apparatus comprising a cassette operable to store documents, the cassette having an external surface, an electrophoretic display coupled with the external surface, and a wireless interface coupled with the cassette and operably coupled with the electrophoretic display. In particular embodiments, the electrophoretic display is operable to receive data representative of configuration from a wireless device in data communication with the wireless interface.

Abstract: A banking system is controlled responsive, at least in part, to data read from data bearing records. The banking system includes an automated banking machine. The machine is operable to carry out a financial transaction responsive to a determination that data read from a data bearing record, such as a card that is read by a card reader in the machine, corresponds to stored information for an authorized user or financial account. The machine is operable to receive and dispense documents. The machine includes a check acceptor that is operative to receive checks and a cash dispenser that is operative to dispense cash. Document holding cassettes in the machine include circuitry that is wirelessly powered through inductive coupling. The machine can wirelessly read data from a cassette through use of induction.

Abstract: In an example embodiment, there is disclosed herein a picker that is operable to separate an individual sheet from a stack of sheets. The picker has a first rotatable picker member that includes a first high friction peripheral arcuate segment, where the first picker member is rotatable about an axis, a second rotatable member that includes a second high friction peripheral arcuate segment, wherein the second picker member is rotatable about the axis, and a drive in operative connection with the first and second rotatable picker members. The stack includes a bounding sheet having a sheet face bounding a side of the stack. The first and second arcuate segments are operable to concurrently engage the sheet face. The first and second picker members are operable to be separately rotationally movable about the axis responsive to operation of the drive.

Abstract: In an example embodiment, there is described herein an apparatus comprising a cassette operable to store documents, the cassette having an external surface, an electrophoretic display coupled with the external surface, and a wireless interface coupled with the cassette and operably coupled with the electrophoretic display. In particular embodiments, the electrophoretic display is operable to receive data representative of configuration from a wireless device in data communication with the wireless interface.

Abstract: A banking system is controlled responsive, at least in part, to data read from data bearing records. The banking system includes an automated banking machine. The machine is operable to carry out a financial transaction responsive to a determination that data read from a data bearing record, such as a card that is read by a card reader in the machine, corresponds to stored information for an authorized user or financial account. The machine is operable to receive and dispense documents. The machine includes a check acceptor that is operative to receive checks and a cash dispenser that is operative to dispense cash. Document holding cassettes in the machine include circuitry that is wirelessly powered through inductive coupling. The machine can wirelessly read data from a cassette through use of induction.

Abstract: A banking system is controlled responsive, at least in part, to data read from data bearing records. The banking system includes an automated banking machine. The machine is operable to carry out a financial transaction responsive to a determination that data read from a data bearing record, such as a card that is read by a card reader in the machine, corresponds to stored information for an authorized user or financial account. The machine is operable to receive and dispense documents. The machine includes a check acceptor that is operative to receive checks and a cash dispenser that is operative to dispense cash. Document holding cassettes in the machine include circuitry that is wirelessly powered through inductive coupling. The machine can wirelessly read data from a cassette through use of induction.

Abstract: A banking system is controlled responsive, at least in part, to data read from data bearing records. The banking system includes an automated banking machine. The machine is operable to carry out a financial transaction responsive to a determination that data read from a data bearing record, such as a card that is read by a card reader in the machine, corresponds to stored information for an authorized user or financial account. The machine is operable to receive and dispense documents. The machine includes a check acceptor that is operative to receive checks and a cash dispenser that is operative to dispense cash. Document holding cassettes in the machine include circuitry that is wirelessly powered through inductive coupling. The machine can wirelessly read data from a cassette through use of induction.

Abstract: In an example embodiment, there is disclosed herein a picker that is operable to separate an individual sheet from a stack of sheets. The picker has a first rotatable picker member that includes a first high friction peripheral arcuate segment, where the first picker member is rotatable about an axis, a second rotatable member that includes a second high friction peripheral arcuate segment, wherein the second picker member is rotatable about the axis, and a drive in operative connection with the first and second rotatable picker members. The stack includes a bounding sheet having a sheet face bounding a side of the stack. The first and second arcuate segments are operable to concurrently engage the sheet face. The first and second picker members are operable to be separately rotationally movable about the axis responsive to operation of the drive.

Abstract: A direct current (DC) powered variable capacity air conditioning system is provided. The system includes a plurality of temperature sensors for monitoring the temperature of various components, locations and air flows within the system. The system additionally includes an integrated controller board that substantially simultaneously controls a variable speed DC compressor motor, a variable speed condenser air mover and a variable speed evaporator air mover in response to inputs from the sensors. By substantially simultaneously controlling the variable speed DC compressor motor, the variable speed condenser air mover and the variable speed evaporator air mover, the system substantially simultaneously controls at least one of a temperature and a volume of an evaporator output air flow. Thus, the system provides a continuum of evaporator output air flow temperatures and capacities for maintaining an approximately constant temperature within an enclosed environment.

Abstract: An evaporator air mover cover for a direct current (DC) powered variable capacity air conditioning system having a housing enclosing an evaporator assembly. The housing defines an air intake opening for intaking air from an enclosed environment into the evaporator assembly. The evaporator air mover cover includes a single piece seamless structure positioned over the air intake opening for covering at least a portion of the air intake opening. Further, the evaporator air mover cover allows air from the enclosed environment to flow through the air intake opening and into the evaporator assembly.

Abstract: A lubrication system for a pneumatically powered instrument is disclosed.

Abstract: A surgical instrument includes a motor assembly, a collet assembly connected to the motor assembly, and a dissection tool such as a bone saw blade. The collet assembly includes a body portion with a plurality of engaging members. The dissection tool includes a tool body with a hub positioned in an opening formed within the tool body. The hub includes a plurality of indentions configured to selectively engage with the engaging members.

Abstract: A surgical cutting tool in which at least one slot is formed through the wall of a tubular housing and receives a blade. An actuator is disposed in the bore and engages the blade so that axial movement of the actuator in the bore causes radial movement of the blade relative to the slot to change the amount of tissue to be removed.