Patents by Inventor Bryan Simpson

Bryan Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating fragile X syndrome and related syndromes
    Patent number: 11497816
    Abstract: Compositions and methods are provided for the inhibition, treatment and/or prevention of fragile X syndrome and related disorders.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: November 15, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Beverly L. Davidson, Carolyn M. Yrigollen, Alejandro Monteys, Bryan Simpson
  • CRISPR/CAS9 GENE EDITING OF ATXN2 FOR THE TREATMENT OF SPINOCEREBELLAR ATAXIA TYPE 2
    Publication number: 20220177878
    Abstract: CRISPR/Cas9-mediated genome editing holds clinical potential for treating genetic diseases, such as spinocerebellar ataxia type 2, which is caused by mutations in the ATXN2 gene. Here, compositions and methods for the treatment of spinocerebellar taxia type 2 are provided. In some embodiments, a composition providing a vector encoding a guide RNA of the disclosure and a vector encoding a Cas9 protein or nuclease domain thereof of the disclosure are provided for use in the treatment of spinocerebellar ataxia type 2.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 9, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Bryan SIMPSON, Beverly DAVIDSON, Alejandro MAS MONTEYS
  • Compositions and Methods for Treating Fragile X Syndrome and Related Syndromes
    Publication number: 20180296698
    Abstract: Compositions and methods are provided for the inhibition, treatment and/or prevention of fragile X syndrome and related disorders.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 18, 2018
    Inventors: Beverly L. Davidson, Carolyn M. Yrigollen, Alejandro Monteys, Bryan Simpson