Patents by Inventor Bryan T. Butman

Bryan T. Butman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5830681
    Abstract: Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1.2, which can be used in immunoassays to predict thrombosis by measuring the extent of activation of prothrombin. These monoclonal antibodies are also included in a kit for performing such immunoassays.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: November 3, 1998
    Assignee: Akzo Nobel N.V.
    Inventors: Marcie J. Hursting, Bryan T. Butman, Jerald P. Steiner, Bryant M. Moore, Frederick A. Dombrose
  • Patent number: 5514541
    Abstract: The present invention relates to monoclonal antibodies, cell lines producing the monoclonal antibodies, assays using the antibodies for the detection of HIV-1 and HIV-2 gene products, and diagnostic kits. More particularly, the monoclonal antibodies react with the p24/p26 capsid protein. Assays using monoclonal antibodies that can simultaneously detect HIV-1 and HIV-2 are disclosed.
    Type: Grant
    Filed: September 13, 1994
    Date of Patent: May 7, 1996
    Assignee: Akzo Nobel N.V.
    Inventors: Bryan T. Butman, Thomas M. Venetta
  • Patent number: 5210181
    Abstract: The instant invention relates to monoclonal antibodies, the cell lines producing those antibodies, the peptides that comprise the epitopes of those antibodies and assays using those antibodies and peptides for the detection of HIV-1 and HIV-2 gene products. In particular, the antibodies react with the p24/p26 capsid protein, the nonapeptide that comprises an HIV-1/HIV-2 conserved epitope is disclosed and a capture ELISA using a combination of three monoclonal antibodies that can detect simultaneously HIV-1 and HIV-2 is disclosed.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: May 11, 1993
    Assignee: Akzo N.V.
    Inventors: Bryan T. Butman, Thomas M. Venetta
  • Patent number: 4950589
    Abstract: Antigens characteristic of all species of Listeria except L. denitrificans comprising proteins found in Listeria heat extracts, the major antigen having a molecular weight of from about 30 to about 38KD and comprising three immunogenically different epitopes and others comprising proteins having a molecular weight range of approximately 17KD to the major antigen and comprising an epitope immunoreactive with antibodies that are also reactive with one of the three epitopes on the 30 to about 38KD protein. The invention also comprises mouse monoclonal antibodies specifically reactive with the identified epitopes on these antigens.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: August 21, 1990
    Assignee: Akzo N.V.
    Inventors: Bryan T. Butman, Jerome A. Mattingly