Abstract: The present disclosure relates to improved biomanufacturing systems and methods with an ability to effectively control process variability to consistently generate high-quality cell-based therapies. In particular, disclosed herein is a using model-based control for determining process parameters in a bioreactor in real time. Additionally disclosed herein is a system for generating an AI digital twin model for a commercial-scale bioreactor.

Abstract: An automated sampling platform includes a gantry-style 2D or 3D actuator equipped with a syringe pump end effector configured to extract samples from a rubber septum placed in-line within a tubing-based system and to deposit the extracted samples into sealed cryovials for storage. This device can be employed for use in cell culture bioreactors, such as the Terumo Quantum, which include a waste line.

Abstract: Systems and methods for language augmented video editing are disclosed. A method includes presenting a video editing assistant (e.g., via a communicatively coupled display and/or speaker). The method includes, in response to receiving a request from a user to create adaptive video content that satisfies a set of characteristics identified based on the request i) analyzing, using a first machine-learning model, existing video content to identify portions of the existing video content that satisfy the set of characteristics and ii) for each portion of the existing video content that satisfies the set of characteristics, create adaptive video content using a respective portion of the existing video content that satisfies the set of characteristics. The method includes generating, using a second machine-learning model, descriptions of the adaptive video content and presenting the adaptive video content and the descriptions of the adaptive video content.

Abstract: A request to perform a memory operation addressed to a first address corresponding to a first logical unit of logical units of a memory is received. Address mask data that corresponds to the logical units is identified. Multiple transformed addresses are determined using the first address and the address mask data. The transformed addresses can include a target address corresponding to the first logical unit and additional addresses corresponding to other logical units. The memory operation is performed at the target address corresponding to the first logical unit and dummy memory operations are performed at the additional addresses corresponding to the additional logical units.

Abstract: Methods, systems, and computer storage media are provided for data extraction. A target document representation may be generated based on modified text of a target electronic document. A measure of similarity may be determined between the target document representation and a reference document representation, which may be based on modified text of a reference electronic document. Based on the measure of similarity, the reference document representation may be selected. An extraction model associated with the selected reference document representation can then be used to extract data from the target document.

Abstract: Methods, systems, and computer storage media are provided for data extraction. A target document representation may be generated based on modified text of a target electronic document. A measure of similarity may be determined between the target document representation and a reference document representation, which may be based on modified text of a reference electronic document. Based on the measure of similarity, the reference document representation may be selected. An extraction model associated with the selected reference document representation can then be used to extract data from the target document.

Abstract: Disclosed is a method for identifying cell-type specific EV markers comprising culturing induced pluripotent stem cells (iPSCs) to provide a culture of a first differentiated cell type; isolating extracellular vesicles (EV)s from the culture of the differentiated cell type; generating a microscopic RNA (miRNA) expression profile for the differentiated cell type by next-generation sequencing; and identifying specific miRNA markers associated with the differentiated cells.

Abstract: Methods, systems, and computer storage media are provided for data extraction. A target document representation may be generated based on modified text of a target electronic document. A measure of similarity may be determined between the target document representation and a reference document representation, which may be based on modified text of a reference electronic document. Based on the measure of similarity, the reference document representation may be selected. An extraction model associated with the selected reference document representation can then be used to extract data from the target document.

Abstract: A novel integrated modular, multi-stage motor-pump/compressor device (10) is disclosed herein. In one example, the device (10) includes an outer housing (12) an electric motor stator (25) positioned within the outer housing (12) and a rotatable integrated motor/pump rotor (18) positioned within the electric motor stator (25). The rotatable integrated motor/pump rotor (18) comprises at least one electromagnet driver device (42, 33, 37) that is adapted to be electromagnetically coupled with the electric motor stator (25) and at least one impeller (28), where an inner surface (34A) of the rotatable integrated motor/pump rotor (18) and the impeller (28) define a primary process fluid flow path (36) within the rotatable integrated motor/pump rotor (18).

Abstract: Methods, systems, and computer storage media are provided for data extraction. A target document representation may be generated based on modified text of a target electronic document. A measure of similarity may be determined between the target document representation and a reference document representation, which may be based on modified text of a reference electronic document. Based on the measure of similarity, the reference document representation may be selected. An extraction model associated with the selected reference document representation can then be used to extract data from the target document.

Abstract: Provided herein are methods of generating a population of enucleated erythroid cells.

Abstract: A novel integrated modular, multi-stage motor-pump/compressor device (10) is disclosed herein. In one example, the device (10) includes an outer housing (12) an electric motor stator (25) positioned within the outer housing (12) and a rotatable integrated motor/pump rotor (18) positioned within the electric motor stator (25). The rotatable integrated motor/pump rotor (18) comprises at least one electromagnet driver device (42, 33, 37) that is adapted to be electromagnetically coupled with the electric motor stator (25) and at least one impeller (28), where an inner surface (34A) of the rotatable integrated motor/pump rotor (18) and the impeller (28) define a primary process fluid flow path (36) within the rotatable integrated motor/pump rotor (18).

Abstract: The invention relates to a compositions and methods for generating and using pIX phage display libraries for producing non-antibody peptide or protein proteins or peptides using engineered hybrid phage vectors derived from pIX of M 13 phage

Abstract: The invention relates to a compositions and methods for generating and using pIX phage display libraries for producing non-antibody peptide or protein proteins or peptides using engineered hybrid phage vectors derived from pIX of M 13 phage

Abstract: Polypeptides comprising EGFR extracellular domains I-III capable of forming dimeric EGF-binding proteins are provided. The dimeric construct of the invention is useful in applications where high affinity EGF binding is desired and can be used to select agents capable of binding to native EGFR in the presence of EGF.

Abstract: An image processing device includes a frame buffer, a first display engine, a clock signal generator, a spread spectrum clock generator, a first-in-first-out (FIFO) buffer and a reset signal generator. The FIFO buffer receives and stores the pixel digital data from the first display engine according to a data writing index controlled by a working clock signal from the clock signal generator and outputs the pixel digital data to the planar display according to a data reading index controlled by a spread spectrum clock signal from the spread spectrum clock generator. The reset signal generator receives and checks the pixel digital data and generates a reset signal to the FIFO buffer to reset the data writing index and the data reading index when one of the pixel digital data to be inputted into the FIFO buffer is consistent with a preset condition.

Abstract: An image processing device includes a frame buffer, a first display engine, a clock signal generator, a spread spectrum clock generator, a first-in-first-out (FIFO) buffer and a reset signal generator. The FIFO buffer receives and stores the pixel digital data from the first display engine according to a data writing index controlled by a working clock signal from the clock signal generator and outputs the pixel digital data to the planar display according to a data reading index controlled by a spread spectrum clock signal from the spread spectrum clock generator. The reset signal generator receives and checks the pixel digital data and generates a reset signal to the FIFO buffer to reset the data writing index and the data reading index when one of the pixel digital data to be inputted into the FIFO buffer is consistent with a preset condition.

Abstract: The present invention provides a method of assessing the ability of a compound (the “test compound”) which is an inhibitor of a biological target to inhibit the biological target in a biological compartment of interest when administered to a subject in vivo.