Patents by Inventor Bryan Winchester

Bryan Winchester has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of lysosomal storage disorders using saposins and other markers
    Publication number: 20050142590
    Abstract: Methods for assaying a lysosomal enzyme activity present in a blood sample obtained from a patient. The method combines the blood or plasma sample in a buffer with at least one binding reagent capable of reacting with alpha-glucosidase present in the blood sample to form an enzyme reagent complex. The lysosomal enzyme activity present in the blood sample is then determined from the enzyme reagent complex formed and compared to a mean level of alpha-glucosidase in a control population of individuals not having a lysosomal storage disease.
    Type: Application
    Filed: October 26, 2004
    Publication date: June 30, 2005
    Applicant: Women's and Children's Hospital
    Inventors: Peter Meikle, John Hopwood, Bryan Winchester
  • Internal standards for sphingolipids
    Publication number: 20050048567
    Abstract: The present invention relates to an internal standard for use in mass spectometry to determine the concentration of a test sphingolipid, the internal standard comprising the same oligosaccharyl chain and long chain base sphingosine as the test sphingolipid and having an acyl group of different mass from the test sphingolipid but providing a sphingolipid of the same chemical nature as the test sphingolipid, and methods for the preparation and use thereof.
    Type: Application
    Filed: November 27, 2002
    Publication date: March 3, 2005
    Inventors: Bryan Winchester, Kevin Mills
  • Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and preparation thereof
    Patent number: 5041555
    Abstract: Novel derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and method for their synthesis from 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol or its triflate derivative are disclosed. The novel derivatives, 6-fluoro-1,4-imino-1,4,6-trideoxy-D-mannitol and the N-butyl and N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-mannitol, have useful mannosidase inhibitory activity.
    Type: Grant
    Filed: September 21, 1990
    Date of Patent: August 20, 1991
    Assignee: Monsanto Company
    Inventors: George W. J. Fleet, Bryan Winchester, Neil M. Carpenter
  • Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and a process for their preparation
    Patent number: 4996329
    Abstract: Novel derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and method for their synthesis from 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol or its triflate derivative are disclosed. The novel derivatives, 6-fluoro-1,4-imino-1,4,6-trideoxy-D-mannitol and the N-butyl and N-benzyl derivatives of 1,4-dideoxy-1,4-amino-D-mannitol, have useful mannosidase inhibitory activity.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: February 26, 1991
    Assignee: Monsanto Company
    Inventors: George W. J. Fleet, Bryan Winchester, Neil M. Carpenter