Abstract: Methods and systems are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

Abstract: Methods are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

Abstract: Methods are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

Abstract: Methods for identifying and evaluating biochemical entities useful as biomarkers for bladder cancer, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for bladder cancer.

Abstract: Molecular tools for differentiating normal breast tissue and cells from cancerous breast tissue and cells are provided. The tools are derived from a novel tumor suppressor gene which encodes a protein referred to hereinafter as the “EDG1” protein. One tool is an isolated polynucleotide which encodes the EDG1 protein. The other tool is an antibody which is immunospecific for the EDG1 protein. Methods of detecting cancerous cells which employ the antibody and polynucleotide are also provided. Methods for decreasing proliferation of breast cancer cells, prostate cancer cells, testicular cancer cells, and ovarian cancer cells are also provided. Such method comprises increasing levels of the EDG1 protein in such cells.

Abstract: Molecular tools for differentiating normal breast tissue and cells from cancerous breast tissue and cells are provided. The tools are derived from a novel tumor suppressor gene which encodes a protein referred to hereinafter as the “EDG1” protein. One tool is an isolated polynucleotide which encodes the EDG1 protein. The other tool is an antibody which is immunospecific for the EDG1 protein. Methods of detecting cancerous cells which employ the antibody and polynucleotide are also provided. Methods for decreasing proliferation of breast cancer cells, prostate cancer cells, testicular cancer cells, and ovarian cancer cells are also provided.