Patents by Inventor Bryan Zeitler

Bryan Zeitler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ZINC FINGER PROTEIN TRANSCRIPTION FACTORS FOR REPRESSING ALPHA-SYNUCLEIN EXPRESSION
    Publication number: 20240018203
    Abstract: The present disclosure provides zinc finger fusion proteins that inhibit expression of alpha-synuclein in the nervous system, and methods of using the proteins to treat Parkinsons disease, Lewy body dementia, multiple system atrophy, Alzheimers disease, and other neurodegenerative diseases.
    Type: Application
    Filed: October 1, 2021
    Publication date: January 18, 2024
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Asa Hatami, Bryan Zeitler, Lei Zhang, David Emanuel Paschon
  • TAU MODULATORS AND METHODS AND COMPOSITIONS FOR DELIVERY THEREOF
    Publication number: 20230270774
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Application
    Filed: October 13, 2022
    Publication date: August 31, 2023
    Applicants: Sangamo Therapeutics, Inc., The General Hospital Corporation
    Inventors: Annemarie Ledeboer, Bryan Zeitler, H. Steve Zhang, Sarah DeVos, Bradley T. Hyman, Susanne Wegmann
  • ZINC FINGER PROTEIN TRANSCRIPTION FACTORS FOR REPRESSING TAU EXPRESSION
    Publication number: 20230242602
    Abstract: The present disclosure provides zinc finger fusion proteins that inhibit expression of tau in the nervous system, and methods of using the proteins to treat neurodegenerative diseases such as Alzheimer's disease, frontotemporal dementia, and other tauopathies.
    Type: Application
    Filed: January 22, 2021
    Publication date: August 3, 2023
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Bryan Zeitler, Asa Hatami, Lei Zhang
  • Zinc Finger Protein Transcription Factors for Treatment of Prion Disease
    Publication number: 20230002459
    Abstract: The present disclosure provides zinc finger fusion proteins that inhibit expression of the prion gene in the nervous system, and methods of using the proteins to treat prion disease.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 5, 2023
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Bryan Zeitler, Lei Zhang
  • Tau modulators and methods and compositions for delivery thereof
    Patent number: 11504389
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 22, 2022
    Assignees: Sangamo Therapeutics, Inc., The General Hospital Corporation
    Inventors: Annemarie Ledeboer, Bryan Zeitler, H. Steve Zhang, Sarah DeVos, Bradley T. Hyman, Susanne Wegmann
  • Zinc Finger Protein Transcription Factors for Repressing Alpha-Synuclein Expression
    Publication number: 20220324928
    Abstract: The present disclosure provides zinc finger fusion proteins that inhibit expression of alpha-synuclein in the nervous system, and methods of using the proteins to treat Parkinson's disease, Lewy body dementia, multiple system atrophy, Alzheimer's disease, and other neurodegenerative diseases.
    Type: Application
    Filed: October 2, 2020
    Publication date: October 13, 2022
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Asa Hatami, Bryan Zeitler, Lei Zhang, David Emanuel Paschon
  • Zinc finger protein compositions for modulation of huntingtin (Htt)
    Patent number: 11421007
    Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: August 23, 2022
    Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.
    Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • Zinc finger protein compositions for modulation of huntingtin (Htt)
    Patent number: 11279739
    Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: March 22, 2022
    Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.
    Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20220064237
    Abstract: Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) an HD HTT allele so as to prevent or treat Huntington Disease, including mHTT repressors (that repress mHTT transcripts and thus also repress mHTT protein expression).
    Type: Application
    Filed: January 15, 2020
    Publication date: March 3, 2022
    Inventors: Galen Carey, Matthew Chiocco, Vivian Choi, Brian Felice, Steven Froelich, Debra Klatte, Jeffrey Miller, David Paschon, Edward Rebar, Bryan Zeitler, Lei Zhang, H. Steve Zhang
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20210369872
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Application
    Filed: August 13, 2021
    Publication date: December 2, 2021
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • Htt repressors and uses thereof
    Patent number: 11123443
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: September 21, 2021
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • ENGINEERED GENETIC MODULATORS
    Publication number: 20200109406
    Abstract: Genetic modulators comprising two or more artificial transcription factors for use in specific and active modulation of gene expression are provided.
    Type: Application
    Filed: October 2, 2019
    Publication date: April 9, 2020
    Inventors: Jeffrey C. Miller, Bryan Zeitler
  • METHODS AND COMPOSITIONS FOR MODULATION OF TAU PROTEINS
    Publication number: 20200101133
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Application
    Filed: October 2, 2019
    Publication date: April 2, 2020
    Inventors: Brigit E. Riley, Bryan Zeitler
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20200002390
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Application
    Filed: August 26, 2019
    Publication date: January 2, 2020
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • ZINC FINGER PROTEIN COMPOSITIONS FOR MODULATION OF HUNTINGTIN (HTT)
    Publication number: 20190322711
    Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
    Type: Application
    Filed: April 17, 2019
    Publication date: October 24, 2019
    Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • HTT repressors and uses thereof
    Patent number: 10435441
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 8, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RARE DISEASES
    Publication number: 20190167815
    Abstract: The present disclosure is in the field of modulation of genes involved in rare diseases including for diagnostics and therapeutics for rare diseases such as Angelman's Syndrome, Facioscapulohumeral Muscular Dystrophy (FHMD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia (FTD) and Spinal Muscular Atrophy (SMA).
    Type: Application
    Filed: October 24, 2018
    Publication date: June 6, 2019
    Inventors: Michael C. Holmes, Brigit E. Riley, Thomas Wechsler, Bryan Zeitler, Lei Zhang
  • Targeted genomic alteration
    Patent number: 10260062
    Abstract: Disclosed herein are methods and compositions for targeted integration and/or targeted excision of one or more sequences into a cell, for example, for expression of one or more polypeptides of interest.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: April 16, 2019
    Assignees: Sangamo Therapeutics, Inc., Dow AgroSciences LLC
    Inventors: William M. Ainley, Michael G. Murray, Fyodor Urnov, Bryan Zeitler
  • TAU MODULATORS AND METHODS AND COMPOSITIONS FOR DELIVERY THEREOF
    Publication number: 20180153921
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 7, 2018
    Inventors: Annmarie Ledeboer, Bryan Zeitler, H. Steve Zhang, Sarah DeVos, Bradley T. Hyman, Susanne Wegmann
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20170096460
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Application
    Filed: September 23, 2016
    Publication date: April 6, 2017
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang