Patents by Inventor Bryce Chaney

Bryce Chaney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7815922
    Abstract: Methods for preparing articles having a bioactive surface comprising treating a substrate to form free reactive groups, depositing a monomer onto the treated substrate, and covalently immobilizing a biologically functional molecule onto the deposited monomer. Additional embodiments include methods for the deposition of the monomer onto the treated substrate in a solvent-free environment. Further embodiments include articles having surfaces prepared using the methods described herein. Additional embodiments include articles prepared using the methods described herein.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: October 19, 2010
    Assignee: Becton, Dickinson and Company
    Inventors: Bryce Chaney, David Montgomery, Ross W. Jacobson
  • Publication number: 20070077651
    Abstract: The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.
    Type: Application
    Filed: November 27, 2006
    Publication date: April 5, 2007
    Applicant: Becton, Dickinson and Company
    Inventors: Richard Guarino, Bryce Chaney, Andrea Liebmann-Vinson, Mohammad Heidaran
  • Patent number: 7198855
    Abstract: The present invention provides methods of producing a surface with enhanced cell-adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self-assembled monolayer comprising at least one exposed functional group. At least one cell-adhesive molecule can then be coupled to the at least one exposed functional group on the self-assembled monolayer to produce a surface with enhanced cell-adhesive properties.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: April 3, 2007
    Assignees: Becton, Dickinson and Company, North Carolina State University
    Inventors: Andrea Liebmann-Vinson, Bryce Chaney, Kirill Efimenko, Jan Genzer
  • Publication number: 20050265980
    Abstract: Compositions and methods for promoting mesenchymal stem cell expansion while maintaining a pluripotent phenotype are disclosed. Serum-free cell culture systems and kits and methods of use for mesenchymal stem cell expansion are provided. Methods also comprise the use of the expanded mesenchymal stem cells to treat various disorders or diseases, particularly those of the cardiovascular system, bone, or cartilage.
    Type: Application
    Filed: May 13, 2005
    Publication date: December 1, 2005
    Applicant: Becton, Dickinson and Company
    Inventors: Chang Chen, Andrea Liebmann-Vinson, Ruiling Xu, Jonathan Rowley, Perry Haaland, Bryce Chaney, Matthew Mitchell
  • Publication number: 20050255327
    Abstract: Methods for preparing articles having a bioactive surface comprising treating a substrate to form free reactive groups, depositing a monomer onto the treated substrate, and covalently immobilizing a biologically functional molecule onto the deposited monomer. Additional embodiments include methods for the deposition of the monomer onto the treated substrate in a solvent-free environment. Further embodiments include articles having surfaces prepared using the methods described herein. Additional embodiments include articles prepared using the methods described herein.
    Type: Application
    Filed: May 16, 2005
    Publication date: November 17, 2005
    Inventors: Bryce Chaney, David Montgomery, Ross Jacobson
  • Publication number: 20050154534
    Abstract: An automated system and method for identifying agents capable of eliciting a phenotypic change in a cell-type. The method includes the steps of providing a statistical design including generic factor names, factor levels and experimental runs, and utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, concentrations or amounts of the agents to the factor levels, and the locations of the receptacles to the experimental runs.
    Type: Application
    Filed: January 13, 2004
    Publication date: July 14, 2005
    Inventors: Perry Haaland, Bryce Chaney, Stacy Holdread
  • Publication number: 20050106727
    Abstract: The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.
    Type: Application
    Filed: September 26, 2003
    Publication date: May 19, 2005
    Applicant: Becton, Dickinson and Company
    Inventors: Richard Guarino, Bryce Chaney, Andrea Liebmann-Vinson, Perry Haaland, Mohammad Heidaran
  • Publication number: 20050058842
    Abstract: The present invention provides methods of producing a surface with enhanced cell-adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self-assembled monolayer comprising at least one exposed functional group. At least one cell-adhesive molecule can then be coupled to the at least one exposed functional group on the self-assembled monolayer to produce a surface with enhanced cell-adhesive properties.
    Type: Application
    Filed: September 12, 2003
    Publication date: March 17, 2005
    Inventors: Andrea Liebmann-Vinson, Bryce Chaney
  • Publication number: 20050059140
    Abstract: The current invention relates to methods of producing a surface with enhanced cell-adhesive properties comprising treating a pre-formed surface such that at least one intermediate reactive group is exposed on the surface. The exposed intermediate reactive group is then reacted to create a self-assembled monolayer, comprising at least one reactive group. The self-assembled monolayer is created non-mechanically. The reactive group is then coupled to at least one cell-adhesive molecule. The current invention also relates to cell culture devices comprising at least one oxygen-sensing compound and a cell-adhesive molecule.
    Type: Application
    Filed: September 12, 2003
    Publication date: March 17, 2005
    Inventors: Andrea Liebmann-Vinson, Bryce Chaney
  • Publication number: 20050036980
    Abstract: The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.
    Type: Application
    Filed: August 15, 2003
    Publication date: February 17, 2005
    Applicant: Becton, Dickinson and Company
    Inventors: Bryce Chaney, Mohammad Heidaran, Andrea Liebmann-Vinson