Patents by Inventor Bryce Chiang

Bryce Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230404799
    Abstract: Provided are methods of delivering a therapeutic agent to the optic nerve head (ONH) of a subject. The methods comprise creating a sclerostomy posterior to the limbus of the subject and feeding a catheter with a distal needle tip tangentially into the sclerostomy. The methods further comprise tunneling the catheter through the suprachoroidal space (SCS) toward the ONH, and disposing the needle tip adjacent, or into, the ONH. The methods further comprise injecting the therapeutic agent adjacent or into the ONH. The methods find use in a variety of contexts, including but not limited to, treating an ONH-associated condition in a subject in need thereof. Examples of such conditions include, but are not limited to, optic neuropathies such as glaucoma, non-arteritic anterior ischemic optic neuropathy (NAION), and the like. Devices and kits that find use in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: June 2, 2023
    Publication date: December 21, 2023
    Inventor: Bryce Chiang
  • Publication number: 20230083551
    Abstract: Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.
    Type: Application
    Filed: November 17, 2022
    Publication date: March 16, 2023
    Inventors: Mark R. Prausnitz, Bryce Chiang
  • Patent number: 11504431
    Abstract: Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: November 22, 2022
    Assignees: Emory University, Georgia Tech Research Corporation
    Inventors: Mark R. Prausnitz, Bryce Chiang
  • Publication number: 20190240336
    Abstract: Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.
    Type: Application
    Filed: July 20, 2017
    Publication date: August 8, 2019
    Applicants: Emory University, Georgia Tech Research Corporation
    Inventors: Mark R. Prausnitz, Bryce Chiang
  • Patent number: 9242094
    Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: January 26, 2016
    Assignee: The Johns Hopkins University
    Inventors: Charles C. Della Santina, Gene Yevgeny Fridman, Bryce Chiang
  • Patent number: 9211407
    Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: December 15, 2015
    Assignee: The Johns Hopkins University
    Inventors: Charles C. Della Santina, Gene Yevgeny Fridman, Bryce Chiang
  • Publication number: 20150209580
    Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.
    Type: Application
    Filed: April 6, 2015
    Publication date: July 30, 2015
    Inventors: Charles C. Della Santina, Gene Yevgeny Fridman, Bryce Chiang
  • Publication number: 20150039057
    Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.
    Type: Application
    Filed: July 28, 2014
    Publication date: February 5, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Charles C. DELLA SANTINA, Gene Yevgeny FRIDMAN, Bryce CHIANG
  • Patent number: 8868202
    Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common erus reference electrode structured to be surgically implanted into a common eras of the vestibular labyrinth.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: October 21, 2014
    Assignee: The Johns Hopkins University
    Inventors: Charles Coleman Della Santina, Gene Yevgeny Fridman, Bryce Chiang
  • Patent number: 8768484
    Abstract: A multichannel vestibular prosthesis includes a sensor system and a microcontroller configured to communicate with the sensor system to receive sensor signals from the sensor system while in operation. The microcontroller is configured to provide control signals in response to the sensor signals. The multichannel vestibular prosthesis also includes a neuroelectronic interface integrated circuit configured to communicate with the microcontroller to receive the control signals, and a plurality of electrodes electrically connected to the neuroelectronic interface integrated circuit. The neuroelectronic interface integrated circuit includes a digital controller configured to communicate with the microcontroller, a plurality of digital-to-analog converters configured to communicate with the digital controller, and a plurality of analog current control circuits, each constructed to communicate with a respective one of the plurality of digital-to-analog converters.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: July 1, 2014
    Assignee: The Johns Hopkins University
    Inventors: Charles Coleman Della Santina, Andreas Andreou, Zaven Kalayjian, Gene Fridman, Bryce Chiang, Julius Georgiou
  • Patent number: 8529463
    Abstract: The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: September 10, 2013
    Assignee: The Johns Hopkins University
    Inventors: Charles C. Della Santina, Tjen Sin Lie, Bryce Chiang
  • Publication number: 20130131761
    Abstract: A multichannel vestibular prosthesis includes a sensor system and a microcontroller configured to communicate with the sensor system to receive sensor signals from the sensor system while in operation. The microcontroller is configured to provide control signals in response to the sensor signals. The multichannel vestibular prosthesis also includes a neuroelectronic interface integrated circuit configured to communicate with the microcontroller to receive the control signals, and a plurality of electrodes electrically connected to the neuroelectronic interface integrated circuit. The neuroelectronic interface integrated circuit includes a digital controller configured to communicate with the microcontroller, a plurality of digital-to-analog converters configured to communicate with the digital controller, and a plurality of analog current control circuits, each constructed to communicate with a respective one of the plurality of digital-to-analog converters.
    Type: Application
    Filed: July 26, 2011
    Publication date: May 23, 2013
    Applicant: The Johns Hopkins University
    Inventors: Charles Coleman Della Santina, Andreas Andreou, Zaven Kalayjian, Gene Fridman, Bryce Chiang, Julius Georgiou
  • Publication number: 20120277835
    Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common erus reference electrode structured to be surgically implanted into a common eras of the vestibular labyrinth.
    Type: Application
    Filed: January 12, 2011
    Publication date: November 1, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Charles Coleman Della Santina, Gene Yevgeny Fridman, Bryce Chiang
  • Publication number: 20110152711
    Abstract: The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes.
    Type: Application
    Filed: April 14, 2009
    Publication date: June 23, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Charles C. Della Santina, Tjen-Sin Lie, Bryce Chiang