Patents by Inventor Bryce Chiang
Bryce Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230404799Abstract: Provided are methods of delivering a therapeutic agent to the optic nerve head (ONH) of a subject. The methods comprise creating a sclerostomy posterior to the limbus of the subject and feeding a catheter with a distal needle tip tangentially into the sclerostomy. The methods further comprise tunneling the catheter through the suprachoroidal space (SCS) toward the ONH, and disposing the needle tip adjacent, or into, the ONH. The methods further comprise injecting the therapeutic agent adjacent or into the ONH. The methods find use in a variety of contexts, including but not limited to, treating an ONH-associated condition in a subject in need thereof. Examples of such conditions include, but are not limited to, optic neuropathies such as glaucoma, non-arteritic anterior ischemic optic neuropathy (NAION), and the like. Devices and kits that find use in practicing the methods of the present disclosure are also provided.Type: ApplicationFiled: June 2, 2023Publication date: December 21, 2023Inventor: Bryce Chiang
-
Publication number: 20230083551Abstract: Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.Type: ApplicationFiled: November 17, 2022Publication date: March 16, 2023Inventors: Mark R. Prausnitz, Bryce Chiang
-
Patent number: 11504431Abstract: Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.Type: GrantFiled: July 20, 2017Date of Patent: November 22, 2022Assignees: Emory University, Georgia Tech Research CorporationInventors: Mark R. Prausnitz, Bryce Chiang
-
Publication number: 20190240336Abstract: Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.Type: ApplicationFiled: July 20, 2017Publication date: August 8, 2019Applicants: Emory University, Georgia Tech Research CorporationInventors: Mark R. Prausnitz, Bryce Chiang
-
Patent number: 9242094Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.Type: GrantFiled: July 28, 2014Date of Patent: January 26, 2016Assignee: The Johns Hopkins UniversityInventors: Charles C. Della Santina, Gene Yevgeny Fridman, Bryce Chiang
-
Patent number: 9211407Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.Type: GrantFiled: April 6, 2015Date of Patent: December 15, 2015Assignee: The Johns Hopkins UniversityInventors: Charles C. Della Santina, Gene Yevgeny Fridman, Bryce Chiang
-
Publication number: 20150209580Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.Type: ApplicationFiled: April 6, 2015Publication date: July 30, 2015Inventors: Charles C. Della Santina, Gene Yevgeny Fridman, Bryce Chiang
-
Publication number: 20150039057Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.Type: ApplicationFiled: July 28, 2014Publication date: February 5, 2015Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Charles C. DELLA SANTINA, Gene Yevgeny FRIDMAN, Bryce CHIANG
-
Patent number: 8868202Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common erus reference electrode structured to be surgically implanted into a common eras of the vestibular labyrinth.Type: GrantFiled: January 12, 2011Date of Patent: October 21, 2014Assignee: The Johns Hopkins UniversityInventors: Charles Coleman Della Santina, Gene Yevgeny Fridman, Bryce Chiang
-
Patent number: 8768484Abstract: A multichannel vestibular prosthesis includes a sensor system and a microcontroller configured to communicate with the sensor system to receive sensor signals from the sensor system while in operation. The microcontroller is configured to provide control signals in response to the sensor signals. The multichannel vestibular prosthesis also includes a neuroelectronic interface integrated circuit configured to communicate with the microcontroller to receive the control signals, and a plurality of electrodes electrically connected to the neuroelectronic interface integrated circuit. The neuroelectronic interface integrated circuit includes a digital controller configured to communicate with the microcontroller, a plurality of digital-to-analog converters configured to communicate with the digital controller, and a plurality of analog current control circuits, each constructed to communicate with a respective one of the plurality of digital-to-analog converters.Type: GrantFiled: July 26, 2011Date of Patent: July 1, 2014Assignee: The Johns Hopkins UniversityInventors: Charles Coleman Della Santina, Andreas Andreou, Zaven Kalayjian, Gene Fridman, Bryce Chiang, Julius Georgiou
-
Patent number: 8529463Abstract: The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes.Type: GrantFiled: April 14, 2009Date of Patent: September 10, 2013Assignee: The Johns Hopkins UniversityInventors: Charles C. Della Santina, Tjen Sin Lie, Bryce Chiang
-
Publication number: 20130131761Abstract: A multichannel vestibular prosthesis includes a sensor system and a microcontroller configured to communicate with the sensor system to receive sensor signals from the sensor system while in operation. The microcontroller is configured to provide control signals in response to the sensor signals. The multichannel vestibular prosthesis also includes a neuroelectronic interface integrated circuit configured to communicate with the microcontroller to receive the control signals, and a plurality of electrodes electrically connected to the neuroelectronic interface integrated circuit. The neuroelectronic interface integrated circuit includes a digital controller configured to communicate with the microcontroller, a plurality of digital-to-analog converters configured to communicate with the digital controller, and a plurality of analog current control circuits, each constructed to communicate with a respective one of the plurality of digital-to-analog converters.Type: ApplicationFiled: July 26, 2011Publication date: May 23, 2013Applicant: The Johns Hopkins UniversityInventors: Charles Coleman Della Santina, Andreas Andreou, Zaven Kalayjian, Gene Fridman, Bryce Chiang, Julius Georgiou
-
Publication number: 20120277835Abstract: An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common erus reference electrode structured to be surgically implanted into a common eras of the vestibular labyrinth.Type: ApplicationFiled: January 12, 2011Publication date: November 1, 2012Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Charles Coleman Della Santina, Gene Yevgeny Fridman, Bryce Chiang
-
Publication number: 20110152711Abstract: The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes.Type: ApplicationFiled: April 14, 2009Publication date: June 23, 2011Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Charles C. Della Santina, Tjen-Sin Lie, Bryce Chiang