Patents by Inventor Brylee David B. Tiu

Brylee David B. Tiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUSTAINED RELEASE COWPEA MOSAIC VIRUS OR VIRUS-LIKE PARTICLE THERAPEUTIC CONSTRUCTS FOR THE TREATMENT OF CANCER
    Publication number: 20230076403
    Abstract: A nanoparticle construct includes a plurality of plant virus or virus-like particles electrostatically coupled to a plurality of nanoparticles having a different surface charge than the plant virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the plant virus or virus-like particles and/or nanoparticles to a cell or tissue of the subject.
    Type: Application
    Filed: September 6, 2022
    Publication date: March 9, 2023
    Inventors: Nicole F. Steinmetz, Frank Alexander Veliz, Brylee David B. Tiu
  • Sustained release cowpea mosaic virus or virus-like particle therapeutic constructs for the treatment of cancer
    Patent number: 11433123
    Abstract: A method of treating cancer in a subject in need thereof includes administering in situ to cancer cells of the subject a nanoparticle construct that includes a plurality of cowpea mosaic virus or virus-like particles electrostatically coupled to a plurality of G4 dendrimers having a different surface charge than the cowpea mosaic virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the cowpea mosaic virus or virus-like particles and/or G4 dendrimers to a cell or tissue of the subject. The cancer selected from the group consisting of melanoma, breast cancer, colon cancer, lung cancer, and ovarian cancer.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: September 6, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Nicole F. Steinmetz, Frank Alexander Veliz, Brylee David B. Tiu
  • PLANT VIRUS OR VIRUS-LIKE PARTICLE CONSTRUCTS
    Publication number: 20210275651
    Abstract: A nanoparticle construct includes a plurality of plant virus or virus-like particles electrostatically coupled to a plurality of nanoparticles having a different surface charge than the plant virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the plant virus or virus-like particles and/or nanoparticles to a cell or tissue of the subject.
    Type: Application
    Filed: July 21, 2017
    Publication date: September 9, 2021
    Inventors: Nicole F. Steinmetz, Frank Alexander Veliz, Brylee David B. Tiu