Patents by Inventor Bryn Hardwick

Bryn Hardwick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the Characterisation of Interaction Sites on Target Proteins
    Publication number: 20190204338
    Abstract: The present invention relates to improved and integrated methods for the characterisation of an interaction site on a target protein that modulates the phenotype of a mammalian cell, such as a phenotype other than death and/or reduced growth. Such methods of the present invention include those to identify a target protein modulates such a phenotype of a mammalian cell, and optionally to characterise an interaction site on said target protein. Such identification and characterisation methods are useful in the development of research tools and/or therapeutics, such protein/peptide or small molecule therapeutics. Accordingly, the present invention also relates to methods of: identification of a ligand, such as a small molecule ligand, that binds to such a target protein; and identification a compound being a candidate modulator of said phenotype of a mammalian cell.
    Type: Application
    Filed: November 13, 2018
    Publication date: July 4, 2019
    Inventors: Paul Watt, Bryn Hardwick, Grahame McKenzie, Ashok Venkitaraman
  • A Method of Screening for Modulation of Cell Signalling Pathways
    Publication number: 20180327869
    Abstract: A method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.
    Type: Application
    Filed: November 12, 2015
    Publication date: November 15, 2018
    Applicant: CAMBRIDGE ENTERPRISE LIMITED
    Inventor: Bryn Hardwick
  • Methods for the Characterisation of Interaction Sites on Target Proteins
    Publication number: 20150105274
    Abstract: The present invention relates to improved and integrated methods for the characterisation of an interaction site on a target protein that modulates the phenotype of a mammalian cell, such as a phenotype other than death and/or reduced growth. Such methods of the present invention include those to identify a target protein modulates such a phenotype of a mammalian cell, and optionally to characterise an interaction site on said target protein. Such identification and characterisation methods are useful in the development of research tools and/or therapeutics, such protein/peptide or small molecule therapeutics. Accordingly, the present invention also relates to methods of: identification of a ligand, such as a small molecule ligand, that binds to such a target protein; and identification a compound being a candidate modulator of said phenotype of a mammalian cell.
    Type: Application
    Filed: February 7, 2013
    Publication date: April 16, 2015
    Applicants: Phylogica Limited, Cambridge Enterprise Limited
    Inventors: Paul Watt, Bryn Hardwick, Grahame McKenzie, Ashok Venkitaraman