Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: A plurality of sensor clusters are provided (61) wherein at least some of the sensor clusters are comprised of at least one light sensitive sensor and a plurality of light emitters. These sensor clusters are disposed (62) in close proximity to a subject user and, in a preferred approach, at least some of the sensor clusters are disposed substantially distal to one another. The light emitters are caused (63) to emit light and the light sensitive sensors are used (64) to detect interactions as between the subject user and the emitted light. These detected interactions are then used (65) to determine the user's heart rate. In a preferred embodiment, the sensed interaction information is dynamically modified as a reflection of how valid the information trajectory appears to be at any given time.