Abstract: Type-1 diabetes (T1 D) results from the autoimmune recognition of insulin producing ?-cells within the pancreatic islet. The present application discloses a new protein, islet homeostasis protein (IHoP), that has a role in glucagon synthesizing-cell functions, and in post-onset T1 D islet differential expression of IHoP. Methods of delaying the onset of diabetes are disclosed, as well as compositions including an iHoP modulating agent. Also disclosed are methods of screening for iHoP modulating agents.

Abstract: Type-1 diabetes (T1 D) results from the autoimmune recognition of insulin producing ?-cells within the pancreatic islet. The present application discloses a new protein, islet homeostasis protein (IHoP), that has a role in glucagon synthesizing-cell functions, and in post-onset T1 D islet differential expression of IHoP. Methods of delaying the onset of diabetes are disclosed, as well as compositions including an iHoP modulating agent. Also disclosed are methods of screening for iHoP modulating agents.

Abstract: Bone marrow cells are induced to differentiate into pancreatic hormone-producing cells in vitro and to repopulate a pancreas in vivo. These insulin-producing cells can be used to regenerate a damaged pancreas and reverse hyperglycemia in mammals.

Abstract: Bone marrow cells are induced to differentiate into pancreatic hormone-producing cells in vitro and to repopulate a pancreas in vivo. These insulin-producing cells can be used to regenerate a damaged pancreas and reverse hyperglycemia in mammals.

Abstract: In vitro and in vivo approaches were used to induce hepatic oval cells to differentiate into cells expressing a neural cell-specific marker and displaying a neural morphology. Increasing cAMP in hepatic oval cells or co-culturing hepatic oval cells with neurospheres caused the hepatic oval cells to develop into cells displaying a neural cell-like phenotype. Hepatic oval cells transplanted into a brain differentiated into cells that phenotypically resembled all of the major cell types in the brain, including astrocytes, neurons, and microglia.

Abstract: A non-naturally occurring method of modulating the targeting a pluripotent stem cell to a target tissue of a mammalian subject from another site in the mammalian subject includes the step of: increasing or decreasing the concentration of SDF-1 alpha protein in the target tissue.