Patents by Inventor Bryony GRAY

Bryony GRAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cellular vamp cleavage assay
    Patent number: 12493035
    Abstract: A method for determining cleavage of a VAMP by a clostridial neurotoxin in a cell that has been contacted with the clostridial neurotoxin under conditions suitable for clostridial neurotoxin activity, the method comprising contacting the cytoplasmic content of the cell with an antibody that binds to a resulting C-terminal product of such cleavage under suitable conditions in vitro or ex vivo and detecting the binding of the antibody to the C-terminal cleavage product. The antibody may, for example, be capable of binding an antigenic polypeptide consisting of 10 to 65 amino acid residues and comprising an epitope comprising an amino acid sequence that is at least 90% identical to an amino acid sequence of at least 8 amino acid residues that is immediately C-terminal to a clostridial neurotoxin cleavage site in the VAMP.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: December 9, 2025
    Assignee: Ipsen Biopharm Limited
    Inventors: Bryony Gray, Verity Cadd, Matthew Beard
  • CELLULAR VAMP CLEAVAGE ASSAY
    Publication number: 20220113310
    Abstract: A method for determining cleavage of a VAMP by a clostridial neurotoxin in a cell that has been contacted with the clostridial neurotoxin under conditions suitable for clostridial neurotoxin activity, the method comprising contacting the cytoplasmic content of the cell with an antibody that binds to a resulting C-terminal product of such cleavage under suitable conditions in vitro or ex vivo and detecting the binding of the antibody to the C-terminal cleavage product. The antibody may, for example, be capable of binding an antigenic polypeptide consisting of 10 to 65 amino acid residues and comprising an epitope comprising an amino acid sequence that is at least 90% identical to an amino acid sequence of at least 8 amino acid residues that is immediately C-terminal to a clostridial neurotoxin cleavage site in the VAMP.
    Type: Application
    Filed: October 22, 2021
    Publication date: April 14, 2022
    Applicant: IPSEN BIOPHARM LIMITED
    Inventors: Bryony GRAY, Verity CADD, Matthew BEARD
  • Cellular vamp cleavage assay
    Patent number: 11193931
    Abstract: A VAMP epitope suitable for generating an antibody against a VAMP C-terminal neurotoxin cleavage product. Method of using such an epitope to generate an antibody against cleaved VAMP. Method of using such an antibody to assay for cleavage of a VAMP by clostridial neurotoxin.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: December 7, 2021
    Assignee: IPSEN BIOPHARM LIMITED
    Inventors: Bryony Gray, Verity Cadd, Matthew Beard
  • CELLULAR VAMP CLEAVAGE ASSAY
    Publication number: 20190219575
    Abstract: A VAMP epitope suitable for generating an antibody against a VAMP C-terminal neurotoxin cleavage product. Method of using such an epitope to generate an antibody against cleaved VAMP. Method of using such an antibody to assay for cleavage of a VAMP by clostridial neurotoxin.
    Type: Application
    Filed: October 18, 2017
    Publication date: July 18, 2019
    Inventors: Bryony GRAY, Verity CADD, Matthew BEARD