Patents by Inventor Buddy D. Ratner

Buddy D. Ratner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10577456
    Abstract: Halogenated cyclic diesters, halogenated polymers derived from the cyclic diesters, and methods for making the halogenated cyclic diesters and related halogenated polymers.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: March 3, 2020
    Inventors: Buddy D. Ratner, Razieh Khalifehzadeh, Esmaeel Naeemi, Chang-Uk Lee, Andrew J. Boydston
  • Publication number: 20180206971
    Abstract: Synthetic polymeric vascular grafts that promote endothelial healing and methods of their preparation and use are provided.
    Type: Application
    Filed: January 24, 2018
    Publication date: July 26, 2018
    Applicant: University of Washington
    Inventors: Buddy D. Ratner, Le Zhen, Felix Simonovsky, Jonathan Himmelfarb
  • Publication number: 20170342205
    Abstract: Halogenated cyclic diesters, halogenated polymers derived from the cyclic diesters, and methods for making the halogenated cyclic diesters and related halogenated polymers.
    Type: Application
    Filed: August 16, 2017
    Publication date: November 30, 2017
    Inventors: Buddy D. Ratner, Razieh Khalifehzadeh, Esmaeel Naeemi, Chang-Uk Lee, Andrew J. Boydston
  • Patent number: 9307905
    Abstract: The present technology relates generally to intraocular pressure (“IOP”) monitoring systems and associated devices and methods. In some embodiments, an intraocular pressure monitoring system configured in accordance with the technology comprises an implantable intraocular assembly and an external unit configured to transmit power to and receive data from the intraocular assembly. The intraocular assembly can include an IOP sensing device embedded within a flexible, expandable annular member. The IOP sensing device can include an antenna, a pressure sensor, and a microelectronic device encapsulated by an elastomer.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: April 12, 2016
    Assignee: University of Washington
    Inventors: Cagdas Varel, Tueng T. Shen, Karl F. Bohringer, Brian Otis, Buddy D. Ratner
  • Publication number: 20150045643
    Abstract: The present technology relates generally to intraocular pressure (“IOP”) monitoring systems and associated devices and methods. In some embodiments, an intraocular pressure monitoring system configured in accordance with the technology comprises an implantable intraocular assembly and an external unit configured to transmit power to and receive data from the intraocular assembly. The intraocular assembly can include an IOP sensing device embedded within a flexible, expandable annular member. The IOP sensing device can include an antenna, a pressure sensor, and a microelectronic device encapsulated by an elastomer.
    Type: Application
    Filed: September 16, 2013
    Publication date: February 12, 2015
    Inventors: Cagdas Varel, Tueng T. Shen, Karl F. Bohringer, Brian Otis, Buddy D. Ratner
  • Publication number: 20140148900
    Abstract: Intraocular devices having a drug delivery construct attached thereto, and methods for using the devices for intraocular drug delivery and the treatment and/or prevention of conditions.
    Type: Application
    Filed: December 20, 2013
    Publication date: May 29, 2014
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Buddy D. Ratner, Tueng T. Shen
  • Publication number: 20140086995
    Abstract: Compositions and methods for localized delivery of a therapeutic agent to a biological tissue over time. The composition includes a temperature-responsive polymer and one or more microspheres, each having degradation rate different from the other, and each comprising a therapeutic agent. In the method, the composition is applied to a biological tissue and forms a gel that adheres to the tissue.
    Type: Application
    Filed: April 12, 2012
    Publication date: March 27, 2014
    Inventors: Buddy D. Ratner, Julee Floyd, Rohan Ramakrishna, Anna Galperin
  • Patent number: 8459032
    Abstract: The present invention relates to hydrogen production for the generation of energy. The invention describes methods, devices and assemblies involving hydrogen production including reacting hydrogen producing compounds, such as organothiol compounds, with a reactive metal substrate to produce hydrogen gas and utilizing the hydrogen gas to generate energy. The present invention further describes regenerating spent compound to a form suitable for hydrogen production by reacting the spent compound with hydrogen. Hydrogen storage and production, as described herein, is useful for producing hydrogen for energy production in hydrogen consuming devices, such as combustible engines and fuel cells, for example, as located on a hydrogen powered vehicle.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: June 11, 2013
    Assignee: Asemblon, Inc.
    Inventors: Buddy D. Ratner, Esmaeel D. Naeemi
  • Patent number: 8318193
    Abstract: The invention provides crosslinked porous biomaterials and methods for forming crosslinked porous biomaterials. The crosslinked porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: November 27, 2012
    Assignee: University of Washington
    Inventors: Buddy D. Ratner, Andrew Marshall
  • Patent number: 8163865
    Abstract: Biocompatible amino acid anhydride polymers for use in tissue engineering, and methods for their preparation and use.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: April 24, 2012
    Assignee: University of Washington
    Inventors: Shrojalkumar M. Desai, Buddy D. Ratner
  • Publication number: 20110287078
    Abstract: The invention provides porous biomaterials and methods for forming porous biomaterials. The porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.
    Type: Application
    Filed: June 9, 2011
    Publication date: November 24, 2011
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Buddy D. Ratner, Andrew Marshall
  • Publication number: 20110256628
    Abstract: The embodiments described herein include porous scaffolds formed from a stimuli-responsive polymer. The stimuli-responsive polymer of the scaffold creates a “smart” scaffold that changes properties in response to an effective stimulus applied to the stimuli-responsive polymer. In a preferred embodiment, an effective stimulus applied to the scaffold initiates a phase transition event in the stimuli-responsive polymer that results in a change in the volume of the pores of the scaffold. The scaffolds can be used to capture appropriately sized objects (e.g., cells) by using the volume-change properties of the pores. Relatedly, the scaffolds can be used as tissue-engineering scaffolds by capturing cells in the pores and introducing the cell-loaded scaffold into a cell-growth environment (e.g., in vivo).
    Type: Application
    Filed: April 20, 2011
    Publication date: October 20, 2011
    Applicant: The University of Washington through its Center for Commercialization
    Inventors: Anna Galperin, Thomas Joseph Long, Buddy D. Ratner
  • Patent number: 7972628
    Abstract: The invention provides porous biomaterials and methods for forming porous biomaterials. The porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: July 5, 2011
    Assignee: University of Washington
    Inventors: Buddy D. Ratner, Andrew Marshall
  • Publication number: 20100074942
    Abstract: Intraocular devices having a drug delivery construct attached thereto, and methods for using the devices for intraocular drug delivery and the treatment and/or prevention of conditions.
    Type: Application
    Filed: September 11, 2009
    Publication date: March 25, 2010
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Buddy D. Ratner, Tueng T. Shen
  • Publication number: 20100015205
    Abstract: Biocompatible amino acid anhydride polymers for use in tissue engineering, and methods for their preparation and use.
    Type: Application
    Filed: August 6, 2009
    Publication date: January 21, 2010
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Shrojalkumar M. Desai, Buddy D. Ratner
  • Patent number: 7442515
    Abstract: In one aspect, the present invention provides devices for binding cells or molecules, wherein each device includes (a) a body defining a first surface and a second surface that is located opposite to the first surface; (b) a heater disposed upon the first surface; and (c) a temperature-responsive layer disposed upon the second surface. In another aspect, the present invention provides methods for binding molecules or living cells to a temperature-responsive material.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: October 28, 2008
    Assignee: University of Washington
    Inventors: Buddy D. Ratner, Xuanhong Cheng, Karl Bohringer, Yanbing Wang, Yael Hanein, Ashutosh Shastry
  • Publication number: 20080075752
    Abstract: The invention provides porous biomaterials and methods for forming porous bioniaterials. The porous bioniaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.
    Type: Application
    Filed: October 1, 2004
    Publication date: March 27, 2008
    Applicant: University of Washington
    Inventors: Buddy D. Ratner, Andrew Marshall
  • Patent number: 7300962
    Abstract: In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds between polymer molecules and bridging molecules, wherein each bridging molecule is linked to at least two polymer molecules, and wherein there are substantially no covalent linkages between the polymer molecules. In some embodiments, the polymer molecules are poly(vinyl alcohol) (PVA) and the bridging molecules are amino acids. Some embodiments of the invention provide devices comprising hydrogels, and pharmaceutical compositions comprising biologically active molecules within hydrogels. Another aspect provides methods for forming hydrogels of the invention.
    Type: Grant
    Filed: August 9, 2005
    Date of Patent: November 27, 2007
    Assignee: University of Washington
    Inventors: Buddy D. Ratner, Prabha D. Nair, Maximiliane Silvia Boeckl, Elizabeth Reeves Leber
  • Patent number: 7192693
    Abstract: In one aspect, the invention provides methods for forming a photopatterned hydrogel. In some embodiments, the methods comprise the step of exposing a solution comprising a monomer, a crosslinking agent, and a photoinitiator to a pattern of light comprising a first and a second light intensity for a period of time and under suitable conditions for the first light intensity to induce essentially complete conversion of polymerizable groups on the monomer and the crosslinking agent to form a patterned hydrogel, and for the second light intensity to induce partial conversion of the polymerizable groups on the monomer and the crosslinking agent to form partially polymerized polymers that remain soluble. In some embodiments, the first light intensity is lower than the second light intensity. In another aspect, the invention provides methods for forming porous, photopatterned hydrogels.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 20, 2007
    Assignee: University of Washington
    Inventors: Stephanie J. Bryant, Kip D. Hauch, Buddy D. Ratner
  • Patent number: 7186396
    Abstract: The present invention relates to hydrogen production for the generation of energy. The invention describes methods, devices and assemblies involving hydrogen production including reacting hydrogen producing compounds, such as organothiol compounds, with a reactive metal substrate to produce hydrogen gas and utilizing the hydrogen gas to generate energy. The present invention further describes regenerating spent compound to a form suitable for hydrogen production by reacting the spent compound with hydrogen. Hydrogen storage and production, as described herein, is useful for producing hydrogen for energy production in hydrogen consuming devices, such as combustible engines and fuel cells, for example, as located on a hydrogen powered vehicle.
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: March 6, 2007
    Assignee: Asemblon, Inc.
    Inventors: Buddy D. Ratner, Esmaeel Naeemi