Patent number: 6303816
Abstract: Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula
R1—L—NHSO2R2 I
in which
R1 represents an unsubstituted or substituted aromatic or heteroaromatic group;
R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and
L represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are at
Type:
Grant
Filed:
October 18, 1999
Date of Patent:
October 16, 2001
Assignee:
Eli Lilly and Company
Inventors:
Macklin B Arnold, Stephen R Baker, David Bleakman, Thomas J Bleisch, Buddy E Cantrell, Ana M Escribano, Ken Matsumoto, Tracey E McKennon, Paul L Ornstein, Richard L Simon, Edward C. R. Smith, Joseph P Tizzano, Hamideh Zarrinmayeh, Dennis M Zimmerman
