Patents by Inventor Buket BADDAL

Buket BADDAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230287355
    Abstract: The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as “Severe Asthma-on-Chip.” In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.
    Type: Application
    Filed: December 19, 2022
    Publication date: September 14, 2023
    Inventors: Remi Villenave, Carolina Lucchesi, Justin Nguyen, Catherine Karalis, Geraldine Hamilton, Buket Baddal, Michael Salmon
  • Patent number: 11542476
    Abstract: The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as “Severe Asthma-on-Chip.” In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: January 3, 2023
    Assignee: EMULATE, INC.
    Inventors: Remi Villenave, Carolina Lucchesi, Justin Nguyen, Catherine Karalis, Geraldine Hamilton, Buket Baddal, Michael Salmon
  • Publication number: 20220305088
    Abstract: Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection.
    Type: Application
    Filed: April 14, 2022
    Publication date: September 29, 2022
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Felipe ALMEIDA DE PINHO RIBEIRO, Pankaj BARAL, Isaac M. CHIU, Nicole J. YANG, Michael WESSELS, Buket BADDAL
  • Patent number: 11400136
    Abstract: Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: August 2, 2022
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Felipe Almeida De Pinho Ribeiro, Pankaj Baral, Isaac M. Chiu, Nicole J. Yang, Michael Wessels, Buket Baddal
  • Publication number: 20210145937
    Abstract: Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection.
    Type: Application
    Filed: June 19, 2018
    Publication date: May 20, 2021
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Felipe ALMEIDA DE PINHO RIBEIRO, Pankaj BARAL, Isaac M. CHIU, Nicole J. YANG, Michael WESSELS, Buket BADDAL