Patents by Inventor Bunji Shimizu

Bunji Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-Fluorouracil derivatives and process for preparing thereof
    Patent number: 4248999
    Abstract: 5-Fluorouracil compounds having a glycoside substituent connected to the 5-fluorouracil nucleus through a bridging oxygen atom; and having anti-tumor activity.
    Type: Grant
    Filed: October 31, 1977
    Date of Patent: February 3, 1981
    Assignee: Sankyo Company Limited
    Inventors: Tsuneo Baba, Masakatsu Kaneko, Bunji Shimizu, Masao Arakawa
  • 7-Methoxycephalosporin derivatives
    Patent number: 4126745
    Abstract: A compound having the formula ##STR1## wherein Y represents a 2-carboxyethylthio group or a trifluoromethylthio group and a nontoxic pharmaceutically acceptable salt thereof are useful as antibacterial agents. They may be prepared by (a) reacting a compound having the formula ##STR2## wherein X.sub.1 represents a halogen atom with a compound having the formulaY -- Hwherein Y has the same meaning as defined above, or (b) reacting a compound having the formula ##STR3## wherein R represents a protective group for the carboxyl group with a compound having the formulaY -- CH.sub.2 COX.sub.2wherein X.sub.2 represents a halogen atom and Y has the same meaning as defined above and removing the protective group for the carboxyl group from the resulting product, or (c) reacting a compound having the formula ##STR4## wherein A represents an acetoxy group or a carbamoyloxy group and Y has the same meaning as defined above with 5-mercapto-1-methyl-1H-tetrazole or its alkali metal salt.
    Type: Grant
    Filed: April 13, 1976
    Date of Patent: November 21, 1978
    Assignee: Sankyo Company Limited
    Inventors: Hideo Nakao, Hiroaki Yanagisawa, Bunji Shimizu, Masakatsu Kaneko, Mitsuo Nagano, Shinichi Sugawara
  • Process for preparing 7-methoxycephalosporin compounds
    Patent number: 4051129
    Abstract: A process for preparing 7.alpha.-methoxycephalosporin compounds which comprises reacting a salt of a 7.beta.-benzylideneamino-7.alpha.-methoxy-3-cephem-4-carboxylic acid with a hydrazine compound to give a salt of a 7.beta.-amino-7.alpha.-methoxy-3-cephem-4-carboxylic acid and reacting the latter compound with a carboxylic acid or its reactive derivative. The products are useful as antibacterial agents.
    Type: Grant
    Filed: November 11, 1975
    Date of Patent: September 27, 1977
    Assignee: Sankyo Company Limited
    Inventors: Bunji Shimizu, Akio Saito, Masakatsu Kaneko, Hiroaki Yanagisawa, Hideo Nakao
  • Cephalosporin derivatives
    Patent number: 4007177
    Abstract: A compound of the formula ##STR1## wherein A represents acetoxy group, carbamoyloxy group or (1-metyl-1H-tetrazol-5-yl)thio group and Y represents propargylthio group, azidomethylthio group, 2-hydroxyethylthio group, 3-isoxazolyloxy group, 3-isoxazolylthio group, methylsulfonyl group, ethylsulfonyl group, 2-cyanoethyl-sulfonyl group or sydnon-3-yl group and nontoxic pharmaceutically acceptable salts thereof are prepared by a process which comprises reacting a compound of the formula ##STR2## wherein R represents a protective group for a carboxyl group and A has the same meaning as defined above with a carboxylic acid of the formulaY - CH.sub.2 COOHwherein Y has the same meaning as defined above or a reactive derivative thereof to give a compound having the formula ##STR3## wherein A, R and Y have the same meanings as defined above and removing the protective group for the carboxyl group from said compound.The compounds are antibacterial agents.
    Type: Grant
    Filed: November 14, 1974
    Date of Patent: February 8, 1977
    Assignee: Sankyo Company Limited
    Inventors: Hideo Nakao, Hiroaki Yanagisawa, Mitsuo Nagano, Bunji Shimizu, Masakatsu Kaneko, Shinichi Sugawara