Patents by Inventor Burcin Ekser

Burcin Ekser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of porcine xenoantigens
    Patent number: 12207629
    Abstract: Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: January 28, 2025
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Burcin Ekser, Ping Li
  • GENETICALLY MODIFIED PORCINE CELLS, TISSUE, AND ANIMALS WITH REDUCED HUMAN XENOREACTIVITY AND METHODS OF USING THE SAME
    Publication number: 20240271103
    Abstract: Disclosed are genetically modified porcine cells, tissues, organoids, and animals and methods of using the same for transplantation, and testing for xenoreactivity.
    Type: Application
    Filed: June 10, 2022
    Publication date: August 15, 2024
    Inventors: Ping LI, Burcin EKSER
  • PROLONGED FUNCTION OF LIVER ORGANOIDS BY 3D COCULTURING OF HEPATIC LINAGE CELLS AS AN IN VITRO MODEL FOR THE STUDY OF LIVER DISEASE
    Publication number: 20220404339
    Abstract: Disclosed is a spheroid liver organoid comprising hepatic lineage cells such as human hepatocytes, hepatic stellate cells, and liver sinusoidal endothelial cells. Also provided are methods of using spheroid liver organoids for applications related to drug screening and toxicity screening. In particular, spheroid liver organoids are useful for high-throughput screens to identify compounds having efficacy for treating liver disease.
    Type: Application
    Filed: September 17, 2020
    Publication date: December 22, 2022
    Inventor: Burcin Ekser
  • Scaffold-free 3D bioprinting of porcine cells
    Patent number: 11479752
    Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: October 25, 2022
    Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventor: Burcin Ekser
  • SCAFFOLD-FREE 3D BIOPRINTING OF PORCINE CELLS
    Publication number: 20220220435
    Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.
    Type: Application
    Filed: March 8, 2022
    Publication date: July 14, 2022
    Inventor: Burcin Ekser
  • Identification of Porcine Xenoantigens
    Publication number: 20220183262
    Abstract: Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.
    Type: Application
    Filed: March 1, 2022
    Publication date: June 16, 2022
    Inventor: Burcin Ekser
  • IDENTIFICATION OF PORCINE XENOANTIGENS
    Publication number: 20190230907
    Abstract: Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.
    Type: Application
    Filed: January 29, 2019
    Publication date: August 1, 2019
    Inventor: Burcin Ekser
  • SCAFFOLD-FREE 3D BIOPRINTING OF PORCINE CELLS
    Publication number: 20190119626
    Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.
    Type: Application
    Filed: October 17, 2018
    Publication date: April 25, 2019
    Inventor: Burcin Ekser