Patents by Inventor Burkhard Raguse

Burkhard Raguse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9874541
    Abstract: A sensor is provided with (i) a pair of electrically conducting electrodes on an electrically insulating substrate; (ii) a chemiresistor film in contact with the pair of electrodes, with an impedance that changes in the presence of an ionic analyte; (iii) a gate electrode formed from an electrically conductive material; (iv) a potential generator configured to apply an electrical potential difference between the gate electrode and the chemiresistor film; (v) a controller to selectively control the potential generator to apply an electric potential to the gate electrode relative to the potential of the chemiresistor film; and (vi) a voltage power source adapted to apply a voltage signal between the pair of electrically conducting electrodes to enable measurement of the resistance of the chemiresistor film.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: January 23, 2018
    Assignee: Commonwealth Scientific and Industrial Research Organization
    Inventors: Burkhard Raguse, Edith Chow
  • Publication number: 20160282302
    Abstract: A sensor is provided for measuring the presence or amount of an ionic analyte in an electrolyte solution.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 29, 2016
    Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Burkhard Raguse, Edith Chow
  • Patent number: 8497130
    Abstract: The present invention provides a chemiresistor-based sensor for measuring the presence or amount of analyte in an electrolyte solution; said chemiresistor comprising (i) a chemiresistor film wherein the impedance of said nanoparticle film changes in the presence of an analyte; and (ii) two electrically conducting electrodes in electrical contact with said nanoparticle film; wherein said electrically conducting electrodes are adapted to be connected to a device for measuring the impedance of said chemiresistor film under a voltage signal and wherein the impedance of the double layer capacitor formed by the two electrically conducting electrodes in the presence of the electrolyte solution, is larger than the impedance of the chemiresistor film either before or after exposure of the chemiresistor film to the analyte. A method of using said chemiresistor-based sensor to measure the presence or amount of analyte is also provided.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: July 30, 2013
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Burkhard Raguse, Edith Chow
  • Patent number: 8309028
    Abstract: The present invention provides a chemiresistor-based sensor for measuring the presence or amount of analyte in an electrolyte solution; said chemiresistor comprising (i) a chemiresistor film wherein the impedance of said nanoparticle film changes in the presence of an analyte; and (ii) two electrically conducting electrodes in electrical contact with said nanoparticle film; wherein said electrically conducting electrodes are adapted to be connected to a device for measuring the impedance of said chemiresistor film under a voltage signal and wherein the impedance of the double layer capacitor formed by the two electrically conducting electrodes in the presence of the electrolyte solution, is larger than the impedance of the chemiresistor film either before or after exposure of the chemiresistor film to the analyte. A method of using said chemiresistor-based sensor to measure the presence or amount of analyte is also provided.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: November 13, 2012
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Burkhard Raguse, Edith Chow
  • Publication number: 20100276302
    Abstract: The present invention provides a chemiresistor-based sensor for measuring the presence or amount of analyte in an electrolyte solution; said chemiresistor comprising (i) a chemiresistor film wherein the impedance of said nanoparticle film changes in the presence of an analyte; and (ii) two electrically conducting electrodes in electrical contact with said nanoparticle film; wherein said electrically conducting electrodes are adapted to be connected to a device for measuring the impedance of said chemiresistor film under a voltage signal and wherein the impedance of the double layer capacitor formed by the two electrically conducting electrodes in the presence of the electrolyte solution, is larger than the impedance of the chemiresistor film either before or after exposure of the chemiresistor film to the analyte. A method of using said chemiresistor-based sensor to measure the presence or amount of analyte is also provided.
    Type: Application
    Filed: February 1, 2008
    Publication date: November 4, 2010
    Inventors: Burkhard Raguse, Edith Chow
  • Publication number: 20090317845
    Abstract: The present invention provides a method for measuring the presence of an analyte in a sample, wherein the presence of the analyte is indicated by the presence or absence of one or more trigger elements that generate an impulsive noise when triggered, comprising the steps of: (a) exposing the one or more trigger elements to a triggering impulse; and (b) detecting the impulsive noise generated by said one or more trigger elements. The present invention further provides reagents that can be used in the method of the present invention.
    Type: Application
    Filed: September 28, 2006
    Publication date: December 24, 2009
    Applicant: Commonwealth Scientific and Industrial research Organisation
    Inventors: Burkhard Raguse, Lech Wieczorek
  • Patent number: 7116209
    Abstract: The present invention provides a strain gauge comprising a resistive layer. The resistive layer comprises metallic or semiconducting nanoparticles or aggregates thereof in which the nanoparticles or aggregates thereof are separated by insulating and/or semiconducting material.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: October 3, 2006
    Assignees: Commonwealth Scientific and Industrial Research Organization, The Commonwealth of Australia as represented by The Defence Science and Technology Organization of the Dept. of Defence
    Inventors: Jan Hermann, Burkhard Raguse, Torsten Reda, Alan Richard Wilson
  • Patent number: 6984265
    Abstract: The present invention provides nanoparticle film and methods of making such films. The nanoparticle film comprises a three dimensional cross-linked array of nanoparticles and linker molecules. The nanoparticle film is coherent, robust and self supporting. The film may be produced by adding linker molecules to a suspension of nanoparticles. The linker molecules form cross-links between the nanoparticles. Prior to completion of the cross-linking reaction the cross-linked nanoparticles are separated from the suspension.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: January 10, 2006
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Burkhard Raguse, Vijoleta Lucija Bronislava Braach-Maksvytis
  • Publication number: 20040239475
    Abstract: The present invention provides a strain gauge comprising a resistive layer. The resistive layer comprises metallic or semiconducting nanoparticles or aggregates thereof in which the nanoparticles or aggregates thereof are separated by insulating and/or semiconducting material.
    Type: Application
    Filed: June 24, 2004
    Publication date: December 2, 2004
    Inventors: Jan Hermann, Burkhard Raguse, Torsten Reda, Alan Richard Wilson
  • Patent number: 6562631
    Abstract: The present invention provides an analyte detection device. The device comprises first and second zones, means to allow addition of a probe to the first zone, means to allow addition of a sample suspected to contain an analyte and means to allow passage of the probe from the first zone to the second zone. The first zone contains ligands reactive with the analyte and the second zone includes a membrane the impedance of which is dependent on the presence or absence of the probe and means to measure the impedance of the membrane. It is preferred that the probe includes an ionophore, preferably gramicidin. The present invention also relates to methods of detecting the presence of an analyte.
    Type: Grant
    Filed: May 15, 1997
    Date of Patent: May 13, 2003
    Assignees: Australian Membrane and Biotechnology Research Institute, The University of Sydney
    Inventors: Vijoleta Lucija Bronislava Braach-Maksvytis, Bruce Andrew Cornell, Lionel George King, Burkhard Raguse
  • Patent number: 6562398
    Abstract: A method of ionically and/or electrically insulating a surface of a material is provided. The method comprises attaching to the surface a self-assembling monolayer membrane. The membrane comprises self-assembling molecules that comprise hydrocarbon chains having a length of 3 to 60 carbons. The self-assembling molecules are selected such that the membrane is liquid crystalline.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: May 13, 2003
    Assignee: Commonwealth Scientific and Industrial Research Organization
    Inventors: Vijoleta Braach-Maksvytis, Burkhard Raguse
  • Publication number: 20030054431
    Abstract: Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed.
    Type: Application
    Filed: June 3, 2002
    Publication date: March 20, 2003
    Inventors: Burkhard Raguse, Ronald John Pace, Lionel Greorge King, Vijoleta Lucija Braach-Makavytie, Bruce Cornell
  • Publication number: 20020164826
    Abstract: The present invention provides an analyte detection device. The device comprises first and second zones, means to allow addition of a probe to the first zone, means to allow addition of a sample suspected to contain an analyte and means to allow passage of the probe from the first zone to the second zone. The first zone contains ligands reactive with the analyte and the second zone includes a membrane the impedance of which is dependent on the presence or absence of the probe and means to measure the impedance of the membrane. It is preferred that the probe includes an ionophore, preferably gramicidin. The present invention also relates to methods of detecting the presence of an analyte.
    Type: Application
    Filed: May 15, 1997
    Publication date: November 7, 2002
    Inventors: VIJOLETA LUCIJA B. BRAACH-MAKSVYTIS, BRUCE ANDREW CORNELL, LIONEL GEORGE KING, BURKHARD RAGUSE
  • Patent number: 6451196
    Abstract: An improved membrane based biosensor incorporates sensing and reference electrodes and a dc electrical potential produced by a counter electrode. The biosensor incorporates ionophores. The conductivity of the membrane is dependent on the presence or absence of an analyte. A functional reservoir exists between the sensing electrode and a lipid membrane deposited on the sensing electrode. The invention also includes the method of detecting the presence or absence of the analyte by use of the biosensor.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: September 17, 2002
    Assignees: Australian Membrane and Biotechnology Research Institute, The University of Sydney
    Inventors: Peter Damien John Osman, Burkhard Raguse, Lech Wieczorek
  • Patent number: 6432629
    Abstract: Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first layer electrode membrane comprising: (1) Forming a solution containing Linker Lipid A, the disulfide of mercaptoacetic acid (MAAD) or similar molecule, linker Gramicidin B, membrane spanning lipid C (MSL-C) and membrane spanning lipid D (MSL-D) or other suitable linker molecules and other ion channel combinations; (2) Contacting an electrode containing a clean gold surface with the solution, the disulfide containing components in the solution thus adsorbing onto the gold surface of the electrode; (3) Rinsing the electrode with a suitable organic solvent; and (4) Removing the excess organic solvent used for rinsing.
    Type: Grant
    Filed: January 7, 1999
    Date of Patent: August 13, 2002
    Assignees: Australian Membrane and Biotechnology Research Institute, The University of Sydney
    Inventors: Burkhard Raguse, Ronald John Pace, Lionel George King, Vijoleta Lucija Braach-Maksvytia, Bruce Cornell
  • Patent number: 6417009
    Abstract: A linker lipid for use in attaching a membrane including a plurality of ionophores to an electrode and providing a space between the membrane and the electrode in which the membrane is either in part or totally made up of the linker lipid. The linker lipid has within the same molecule a hydrophobic region capable of spanning the membrane, an attachment group used to attach the molecule to an electrode surface, a hydrophilic region intermediate the hydrophobic region and the attachment group, and a polar head group region attached to the hydrophobic region at a site remote from the hydrophilic region. The attachment group has a cross sectional area greater than the cross sectional area of the hydrophilic region, and has the structure recited in the specification.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: July 9, 2002
    Assignees: Australian Membrane and Biotechnology Institute, The University of Sydney
    Inventors: Burkhard Raguse, Christopher John Burns, Leslie David Field, Damon Donald Ridley
  • Patent number: 6348319
    Abstract: The present invention provides a biosensor for use in detecting the presence of an enzyme or enzymes in a sample. The biosensor comprises a membrane and means for determining the impedance of the membrane. The membrane includes ionophores therein to which are attached linkers. The linkers are cleavable by the enzyme or enzymes to be detected, with the cleavage of the linker causing a change in the ability of ions to pass through the membrane via the ionophores.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: February 19, 2002
    Assignees: Australian Membrane and Biotechnology Research Institute, University of Sydney
    Inventors: Vijoleta Lucija Bronislava Braach-Maksvytis, Bruce Andrew Cornell, David Geoffrey Thomson, Burkhard Raguse
  • Patent number: 6342346
    Abstract: Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first layer electrode membrane comprising: (1) Forming a solution containing Linker Lipid A, the disulfide of mercaptoacetic acid (MAAD) or similar molecule, linker Gramicidin B, membrane spanning lipid C (MSL-C) and membrane spanning lipid D (MSL-D) or other suitable linker molecules and other ion channel combinations; (2) Contacting an electrode containing a clean gold surface with the solution, the disulfide containing components in the solution thus adsorbing onto the gold surface of the electrode; (3) Rinsing the electrode with a suitable organic solvent; and (4) Removing the excess organic solvent used for rinsing.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: January 29, 2002
    Assignee: Australian Membrane and Biotechnology Research Institute
    Inventors: Burkhard Raguse, Ronald John Pace, Lionel George King, Vijoleta Lucija Braach-Maksvytis, Bruce Cornell
  • Patent number: 6291155
    Abstract: Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first layer electrode membrane comprising: (1) Forming a solution containing Linker Lipid A, the disulfide of mercaptoacetic acid (MAAD) or similar molecule, linker Gramicidin B, membrane spanning lipid C (MSL-C) and membrane spanning lipid D (MSL-D) or other suitable linker molecules and other ion channel combinations; (2) Contacting an electrode containing a clean gold surface with the solution, the disulfide containing components in the solution thus adsorbing onto the gold surface of the electrode; (3) Rinsing the electrode with a suitable organic solvent; and (4) Removing the excess organic solvent used for rinsing.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: September 18, 2001
    Assignee: Australian Membrane and Biotechnology Research Institute
    Inventors: Burkhard Raguse, Ronald John Pace, Lionel George King, Vijoleta Lucija Braach-Maksvytis, Bruce Cornell
  • Patent number: 5879878
    Abstract: Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first layer electrode membrane comprising:(1) Forming a solution containing Linker Lipid A, the disulfide of mercaptoacetic acid (MAAD) or similar molecule, linker Gramicidin B, membrane spanning lipid C (MSL-C) and membrane spanning lipid D (MSL-D) or other suitable linker molecules and other ion channel combinations;(2) Contacting an electrode containing a clean gold surface with the solution, the disulfide containing components in the solution thus adsorbing onto the gold surface of the electrode;(3) Rinsing the electrode with a suitable organic solvent; and(4) Removing the excess organic solvent used for rinsing.
    Type: Grant
    Filed: July 23, 1996
    Date of Patent: March 9, 1999
    Assignees: Australian Membrane and Biotechnology Research Institute, The University of Sydney
    Inventors: Burkhard Raguse, Ronald John Pace, Lionel George King, Vijoleta Licija Braach-Makavytie, Bruce Cornell