Patents by Inventor Burns C. Blaxall

Burns C. Blaxall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATMENT OF FIBROSIS
    Publication number: 20190216889
    Abstract: Disclosed herein are methods of treating fibrosis in an individual in need thereof. The disclosed methods employ a peptide (“pUR4”) in an amount effective to reverse, attenuate, or prevent fibrosis in an individual in need thereof. The disclosed methods and compositions may be used for treatment of fibrosis, including liver fibrosis, pulmonary fibrosis, cardiac fibrosis, kidney fibrosis, skin fibrosis, ischemia-induced fibrosis, periglomerular fibrosis, fibrosis resulting from an injury, fibrosis resulting from an obstructive event, fibrosis resulting from a nephrotoxic event, or combinations thereof.
    Type: Application
    Filed: January 16, 2019
    Publication date: July 18, 2019
    Inventors: Burns C. Blaxall, Prasad Devarajan, Stephanie R. Davis-Rodriguez
  • Treatment of fibrosis-related disorders using fibronectin binding proteins and polypeptides
    Patent number: 9364516
    Abstract: The present invention is directed to various uses of fibronectin binding proteins or polypeptides for treating and preventing fibrosis and fibrosis related conditions. The fibronectin binding proteins and polypeptides are also useful for treating conditions associated with vascular remodeling and cardiac dysfunction.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: June 14, 2016
    Assignee: University of Rochester
    Inventors: Jane Sottile, Burns C. Blaxall
  • Compositions and methods for inhibiting G protein signaling
    Patent number: 8975259
    Abstract: Disclosed are compositions and methods for treating diseases associated with G protein ?? subunit activity.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: March 10, 2015
    Assignee: University of Rochester
    Inventors: Alan V Smrcka, Burns C. Blaxall, Jean M. Bidlack
  • TREATMENT OF FIBROSIS-RELATED DISORDERS USING FIBRONECTIN BINDING PROTEINS AND POLYPEPTIDES
    Publication number: 20130190224
    Abstract: The present invention is directed to various uses of fibronectin binding proteins or polypeptides for treating and preventing fibrosis and fibrosis related conditions. The fibronectin binding proteins and polypeptides are also useful for treating conditions associated with vascular remodeling and cardiac dysfunction.
    Type: Application
    Filed: February 3, 2011
    Publication date: July 25, 2013
    Applicants: MAX-PLANCK-GESELLSCHAFT zur FORDERUNG der WISSENSCHAFTEN e.V., UNIVERSITY OF ROCHESTER
    Inventors: Jane Sottile, Inaam Nakchbandi, Burns C. Blaxall
  • COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING
    Publication number: 20100130505
    Abstract: Disclosed are compositions and methods for treating diseases associated with G protein ?? subunit activity.
    Type: Application
    Filed: April 28, 2008
    Publication date: May 27, 2010
    Applicant: University of Rochester
    Inventors: Alan V. Smrcka, Burns C. Blaxall, Jean M. Bidlack
  • METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS
    Publication number: 20090022729
    Abstract: The present invention provides methods and pharmaceutical compositions for treating or preventing cardiac dysfunctions (e.g., cardiac hypertrophy, cardiac remodeling, or heart failure) in subjects who have or are likely to develop cardiomyopathies. Some of the methods are directed to therapeutic or prophylactic treatment of cardiac dysfunctions in subjects having undergone myocardial injuries such as cardiac ischemia/reperfusion or myocardial infarction. Typically, these methods comprising administering to the subjects a therapeutic composition comprising a compound which can specifically inhibit PAR1 mediated signaling or down-regulate the cellular level of PAR1.
    Type: Application
    Filed: April 11, 2008
    Publication date: January 22, 2009
    Inventors: Nigel Mackman, Rafal Pawlinski, Burns C. Blaxall