Abstract: Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

Abstract: Discrete time compensation mechanisms include a channel component configured for determining which channel of a plurality of channels to process time slots of sampled data that are time stamped in a discrete time and processing the time slots of the sampled data to the plurality of channels. A common channel clock component is configured for time stamping the time slots of the sampled data in the discrete time domain that is faster than a non-discrete reference time stamp of continuous data from which the time slots are sampled from and for processing the sampled data through the plurality of channels faster than the continuous data is being received. Compensations for one or more gaps are generated based on a set of predetermined criteria and a corrected time stamp is applied to the sampled data for processing among different processing channels.

Abstract: Discrete time compensation mechanisms include a channel component configured for determining which channel of a plurality of channels to process time slots of sampled data that are time stamped in a discrete time and processing the time slots of the sampled data to the plurality of channels. A common channel clock component is configured for time stamping the time slots of the sampled data in the discrete time domain that is faster than a non-discrete reference time stamp of continuous data from which the time slots are sampled from and for processing the sampled data through the plurality of channels faster than the continuous data is being received. Compensations for one or more gaps are generated based on a set of predetermined criteria and a corrected time stamp is applied to the sampled data for processing among different processing channels.