Abstract: Bioengineered scaffolds are described, using human skin proteins in an architectural orientation that mimics the extracellular matrix, demonstrating improved cutaneous wound closure in vivo alone, and when incorporating therapeutics such as platelet-rich plasma, stem cells, and growth factors that promote accelerated wound healing compared to control therapy. An electrospun scaffold comprising human collagen I and tropoelastin in physiologically relevant amounts and proportions encourage a chronic wound that is halted in the inflammatory phase to progress into the remodeling phase. Data demonstrates full thickness, splinted wounds in diabetic mice were treated with biomimetic scaffolds to assess wound healing and the resulting remodeled tissue mechanical properties.

Abstract: Business methods, processes and systems for collection, storage and distribution of a biological sample material for producing a cosmetic formulation product.

Abstract: Business methods, processes and systems for collection, storage and distribution of a biological sample material for producing a cosmetic formulation product.

Abstract: The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter or a viral promoter. The sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the nucleic acid or protein.

Abstract: The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter or a viral promoter. The sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the nucleic acid or protein.

Abstract: The present invention provides compositions and methods for promoting wound healing. The composition comprises virgin monomers of tropoelastin and lysyl oxidase. When the lysyl oxidase comes in contact with the tropoelastin, cross-linking of the tropoelastin monomers will occur to form elastin. Contacting the tropoelastin and lysyl oxidase together and applying the mixture to a wound before substantial cross-linking has occurred promotes wound healing by holding the damaged tissue together, increasing the rate of healing, and decreasing the amount of scarring.

Abstract: The present invention relates to compositions and systems for expressing pharmaceutically active gene products in plants. In particular, the invention provides compositions, systems and methods for the production of human growth hormone in plants. Provided are nucleic acid and protein sequences, expression and vector constructs, host cells and plants capable of expressing human growth hormone, and compositions and kits comprising produced human growth hormone. Additionally provided are methods for production and use of the compositions of the invention.

Abstract: The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter or a viral promoter. The sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the nucleic acid or protein.

Abstract: A method of producing metal-rich plants for the production of nutritional supplements. Edible plants are placed in a growth environment containing metal, and are cultivated in a fashion which enhances the uptake of metal into edible portions of the plants. The plants are then harvested, and may be eaten directly or processed into capsule or tablet form, in order to obtain the metallic nutrients so incorporated.

Abstract: The present invention provides compositions and methods for promoting wound healing. The composition comprises virgin monomers of tropoelastin and lysyl oxidase. When the lysyl oxidase comes in contact with the tropoelastin, cross-linking of the tropoelastin monomers will occur to form elastin. Contacting the tropoelastin and lysyl oxidase together and applying the mixture to a wound before substantial cross-linking has occurred promotes wound healing by holding the damaged tissue together, increasing the rate of healing, and decreasing the amount of scarring.

Abstract: The present invention provides systems and methods for producing pharmaceutically active proteins in transgenic sprouted seedlings. The transgenic sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter. The transgenic sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the pharmaceutically active protein.

Abstract: Methods and systems for alleviating the environmental and health hazards associated with environmental contamination by metals are provided. Contained living or non-viable biomasses of metal-accumulating plant seedlings deplete the metal elements and compounds in metal-containing aqueous solutions. Concomitantly, the contained biomasses of plant seedlings accumulate the metal elements and compounds. The energy and nutrient stores of the seeds from which the seedlings develop are exploited to minimize the costs of remediating the metal-containing aqueous solutions.

Abstract: Methods and systems for alleviating the environmental and health hazards associated with environmental contamination by metals are provided. Contained living or non-viable biomasses of metal-accumulating plant seedlings deplete the metal elements and compounds in metal-containing aqueous solutions. Concomitantly, the contained biomasses of plant seedlings accumulate the metal elements and compounds. The energy and nutrient stores of the seeds from which the seedlings develop are exploited to minimize the costs of remediating the metal-containing aqueous solutions.