Patents by Inventor Burton Christensen

Burton Christensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel antibacterial agents
    Publication number: 20070196859
    Abstract: This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked ) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall.
    Type: Application
    Filed: November 21, 2006
    Publication date: August 23, 2007
    Inventors: Burton Christensen, Edmund Moran, John Griffin, J. Judice, YongQi Mu, John Pace, Mathai Mammen, James Aggen
  • Novel antibacterial agents
    Publication number: 20070154948
    Abstract: This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall.
    Type: Application
    Filed: November 21, 2006
    Publication date: July 5, 2007
    Inventors: Burton Christensen, Edmund Moran, John Griffin, J. Judice, YongQi Mu, John Pace, Mathai Mammen, James Aggen
  • Novel antibacterial agents
    Publication number: 20070134729
    Abstract: This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall.
    Type: Application
    Filed: November 21, 2006
    Publication date: June 14, 2007
    Inventors: Burton Christensen, Edmund Moran, John Griffin, J. Judice, YongQi Mu, John Pace, Mathai Mammen, James Aggen
  • Isoxazolidine compounds for treatment of bacterial infections
    Publication number: 20060020004
    Abstract: The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.
    Type: Application
    Filed: June 17, 2005
    Publication date: January 26, 2006
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Burton Christensen, Michael Foley, Asimina Georges Evangelinos, Tao Liu, James Porter, Amy Ripka, Linping Zhang
  • Cephalosporin antibiotics
    Patent number: 5756493
    Abstract: The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to .beta.-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: May 26, 1998
    Assignee: Microcide Pharmaceuticals, Inc.
    Inventors: Scott Hecker, In-Seop Cho, Tomasz Glinka, Burton Christensen
  • Cephalosporin antibiotics
    Patent number: 5698547
    Abstract: The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to .beta.-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: December 16, 1997
    Assignee: Microcide Pharmaceuticals, Inc.
    Inventors: Burton Christensen, In-Seop Cho, Tomasz Glinka, Scott Hecker, Ving J. Lee, Zhijia J. Zhang
  • .beta.-lactam antibiotics
    Patent number: 5688786
    Abstract: The present invention includes novel compounds or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to .beta.-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 18, 1997
    Assignee: Microcide Pharmaceuticals, Inc.
    Inventors: Burton Christensen, Tomasz Glinka, Ving J. Lee, Scott Hecker
  • Cephalosporin antibiotics
    Patent number: 5604218
    Abstract: The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to .beta.-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: February 18, 1997
    Assignee: Microcide Pharmaceuticals, Inc.
    Inventors: Scott Hecker, In-Seop Cho, Burton Christensen, Tomasz Glinka, Ving J. Lee
  • 3-(.bet a.-Hydroxyethylidene)-6-(.alpha.-Hydroxyethyl)-7-oxo-4-oxaazabicyclo[3.2. 0]heptene-2-carboxylic acid and derivatives thereof
    Patent number: 4076826
    Abstract: 3-(.beta.-Hydroxyethylidene)-6-(.alpha.-Hydroxyethyl)-7-oxo-4-oxaazabicyclo [3.2.0]heptane-2-carboxylic acid having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed to be useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: August 6, 1976
    Date of Patent: February 28, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton A. Christensen, Robert B. Morin, Edward Walton