Patents by Inventor by Dorte Buchardt, representative

by Dorte Buchardt, representative has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
    Patent number: 5736336
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: April 7, 1998
    Inventors: Ole Buchardt, deceased, by Dorte Buchardt, representative, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg
  • Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
    Patent number: 5714331
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: February 3, 1998
    Inventors: Ole Buchardt, deceased, by Dorte Buchardt, representative, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg