Abstract: The present invention relates to a pharmaceutical composition for improving cognitive ability or enhancing memory, and more specifically, to a health functional food for improving cognitive ability or enhancing memory, and a composite pharmaceutical composition for improving cognitive ability or enhancing memory, which are mixed compositions, respectively, for co-administration with other active materials exhibiting an effect of improving cognitive ability or enhancing memory. The pharmaceutical composition for improving cognitive ability or enhancing memory, according to the present invention, has been confirmed to exhibit an effect of significantly reducing cognitive impairment or memory loss caused by neurodegenerative brain diseases or inflammatory brain diseases such as autism, Alzheimer's disease, Parkinson's disease, peripheral neuropathy, amyotrophic lateral sclerosis, ischaemia, stroke and multiple sclerosis, etc.

Abstract: Disclosed herein is a method for predicting or diagnosing psychiatric disorders through analyzing skin tissues samples minimally invasive or non-invasively collected. The method disclosed herein makes it possible to diagnose psychiatric disorders through objective biomarkers at a very early age, without giving pain to subjects because of noninvasive or minimally invasive feature of skin sample collection method.

Abstract: The present invention relates to a composition for skin external application. Specifically, a composition for skin external application comprising a stably formed lamella liquid crystal phase can be provided according to the present invention. In addition, according to the present invention, the composition can provide excellent skin moisturizing and skin barrier strengthening effects upon application on the skin, as well as act effectively as an agent for a cannabinoid type 1 receptor, such that it is expected that the present invention can provide a very effective effect for treatment or improvement of skin diseases and mental disorders associated with skin diseases.

Abstract: The present invention relates to a composition for skin external application. Specifically, a composition for skin external application comprising a stably formed lamella liquid crystal phase can be provided according to the present invention. In addition, according to the present invention, the composition can provide excellent skin moisturizing and skin barrier strengthening effects upon application on the skin, as well as act effectively as an agent for a cannabinoid type 1 receptor, such that it is expected that the present invention can provide a very effective effect for treatment or improvement of skin diseases and mental disorders associated with skin diseases.

Abstract: An autophage activating resveratrol topical composition includes a ceramide or a pseudoceramide, a fatty acid, a phytosterol, and a resveratrol. The ceramide or pseudoceramide, the fatty acid, the phytosterol, and the resveratrol form a multi-layered encapsulation system. A method of inducing autophagy in skin includes applying the autophage activating resveratrol topical composition to a skin, and inducing autophagy in the skin to improve skin barrier function and skin self-purification function.

Abstract: An autophage activating resveratrol topical composition includes a ceramide or a pseudoceramide, a fatty acid, a phytosterol, and a resveratrol. The ceramide or pseudoceramide, the fatty acid, the phytosterol, and the resveratrol form a multi-layered encapsulation system. A method of inducing autophagy in skin includes applying the autophage activating resveratrol topical composition to a skin, and inducing autophagy in the skin to improve skin barrier function and skin self-purification function.

Abstract: Disclosed herein is a method for predicting or diagnosing psychiatric disorders through analyzing skin tissues samples minimally invasive or non-invasively collected. The method disclosed herein makes it possible to diagnose psychiatric disorders through objective biomarkers at a very early age, without giving pain to subjects because of noninvasive or minimally invasive feature of skin sample collection method.

Abstract: The composition of external application to the skin according to the present invention may specifically control the relative amount between long-chain amides and sterols and the relative amount between lipid components and an emulsifier in the emulsion having a multi-layered lamella structure, the emulsion comprising a relatively larger content of dermatologically useful hydrophobic material in a formulation. Thus, the formulation having significantly high stability and excellent characteristics can be obtained in spite of the high content in the lipid components and the emulsifier.

Abstract: The composition of external application to the skin according to the present invention may specifically control the relative amount between long-chain amides and sterols and the relative amount between lipid components and an emulsifier in the emulsion having a multi-layered lamella structure, the emulsion comprising a relatively larger content of dermatologically useful hydrophobic material in a formulation. Thus, the formulation having significantly high stability and excellent characteristics can be obtained in spite of the high content in the lipid components and the emulsifier.

Abstract: Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.

Abstract: The heterocyclic compound according to the present invention may treat and prevent inflammatory diseases and heal skin wounds, and particularly, have effects of recovering damaged skin barrier, reducing inflammation and pruritus in inflammatory skin diseases. In addition, the composition containing the compound according to the present invention as an active ingredient may be used to alleviate various inflammatory diseases and diseases in which PAR-2 is excessively expressed, and particularly, the composition may inhibit activity of PAR-2 in skin, such that the composition may be used as a composition having anti-inflammatory function in inflammatory skin diseases including atopic dermatitis, or the like.

Abstract: Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.

Abstract: Disclosed herein is the use of a non-natural compound represented by the following formula 1 as an activator of the peroxisome proliferator activated receptor-? (PPAR-?) which shows an anti-inflammatory effect on inflammatory skin diseases. The PPAR-? activator increases the expression of PPAR-? in the skin to enhance various physiological effects of PPAR-?, that is, the anti-inflammatory effect caused by inhibiting the activity of transcription factors such as the nuclear factor ?K (NF-?K) that induces inflammatory reactions, the effect of improving the epidermal permeability barrier function of the skin, and the effect of promoting the terminal differentiation of epidermal keratinocytes. Thus, the PPAR-? activator is useful for the treatment, alleviation or amelioration of skin diseases such as acne, seborrheic dermatitis, viral skin diseases, urticaria, pruritus, viral infectious diseases and contact dermatitis.

Abstract: Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

Abstract: Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

Abstract: Disclosed herein are novel microorganisms having excellent biodegradability and a method for the bioremediation of oil-contaminated soil. The novel microorganisms are specified as Rhodococcus baikoneurensis EN3 KCTC19082, Acinetobacter johnsonii EN67 KCTC12360 and Acinetobacter haemolyticus EN96 KCTC12361. In the bioremediation method, in addition to said novel microorganisms, various microorganisms of Nocardia sp., Gordonia sp., Rhodococcus sp. and Acinetobactor sp. can be used, and the oil biodegradation activities of these microbial strains can be increased by adding biosurfactant 2-alkyl-3-hydroxylic acid or its derivative. According to the disclosed invention, oil-contaminated soils can be purified in an effective, economical and eco-friendly manner compared to prior bioremediation methods.

Abstract: Disclosed is a skin external preparation containing stratum corneum intercellular lipids, ceramide, and having a hexagonal gel structure. More particularly, the skin external preparation having the hexagonal gel structure contains, as stratum corneum intercellular lipid components, ceramide and cholesterol or its derivative and/or fatty acid, and as an emulsifying agent, sorbitan stearate, sucrose cocoate or a mixture thereof. The hexagonal gel structure of the external preparation is in the same form as a lamellar structure formed by stratum corneum intercellular lipids on the actual skin, and this lamellar structure plays a very important role in skin protection and moisturizing functions, and thus provides very useful effects for skin showing a damaged skin barrier function in various skin diseases or various skin types.

Abstract: Disclosed is a non-natural ceramide compound effective for a sphingosine kinase activator, and thus useful for a skin disease treating agent. The sphingosine kinase activator enhances production of sphingosine-1-phosphate to show various physiological activities provided by sphingosine-1-phosphate. The physiological activities include the effects of: controlling multiplication and differentiation of keratinocytes, multiplication of fibroblasts and collagen synthesis, resulting in treatment of wounds, recovery of damaged skin functions in atopic dermatitis and psoriasis; inhibiting wrinkles and skin irritation caused by ultraviolet rays, followed by improvement of wrinkles and inhibition of skin aging; and reducing skin atrophy, which is a typical side effect of local application steroids.

Abstract: The present invention relates to pseudoceramide derivatives represented by formula(I) or (II): R1—COCHR2CONR3R4  (I) R1—CH(OH)CHR2CONR3R4  (II) wherein, each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6˜22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2˜C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in an dermatologic external preparations the moisture-retaining property and resilience of skin and hair is enhanced such so that the derivatives are useful in protection of skin-aging. In addition, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.