Patents by Inventor Byeong Hyeok Choi

Byeong Hyeok Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170291958
    Abstract: Described herein is a method of modulating sumoylation of a Ras protein by small ubiquitin-like modifier (SUMO) proteins. Provided herein is a method for regulating the activity of a Ras protein. Also provided is a treatment of proliferative diseases, such as cancer, by introducing specific mutations to a mutant Ras protein that is associated with the proliferative disease. Described herein is a modified Ras protein. Described herein are recombinant vectors, cells comprising the vectors expressing the modified Ras proteins. Provided herein is an antibody that specifically binds to a sumoylated Ras protein. Described herein is a method for identifying an agent that interferes with the sumoylation of a Ras protein. Also described herein are therapeutic and prophylactic compositions. Also provided herein is a method of using a modified Ras protein to replace an endogenous mutant Ras protein that is associated with a proliferative disease.
    Type: Application
    Filed: April 11, 2017
    Publication date: October 12, 2017
    Inventors: Wei Dai, Mark R. Philips, Byeong Hyeok Choi