Patents by Inventor Byoung Gon Moon

Byoung Gon Moon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic pig expressing sTNFR1-Fc genes and the uses thereof
    Patent number: 9357754
    Abstract: The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-? in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: June 7, 2016
    Assignee: SNU R&DB FOUNDATION
    Inventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Byoung Gon Moon, Goo Jang, Bum Rae Cho, Ok Jae Koo, Sol Ji Park, Jung Taek Kang, Dae Kee Kwon
  • TRANSGENIC PIG EXPRESSING STNFR1-FC GENES AND THE USES THEREOF
    Publication number: 20140026233
    Abstract: The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-? in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.
    Type: Application
    Filed: January 20, 2012
    Publication date: January 23, 2014
    Applicant: SNU R&DB FOUNDATION
    Inventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Byoung Gon Moon, Goo Jang, Bum Rae Cho, Ok Jae Koo, Sol Ji Park, Jung Taek Kang, Dae Kee Kwon