Abstract: The disclosure provides for methods to determine prognosis, aggressiveness, and progression of prostate cancer with the ability to differentiate between aggressive and non-aggressive prostate cancer. The method utilizes the differential enzymatic activity in patient samples, for example of enzymatically active prostate specific antigen (PSA) activity, in order to determine the aggressiveness and prognosis of prostate cancer, and monitor the progression of prostate cancer therapy. The invention also encompasses assay platforms (e.g., optical or electrochemical) that specifically detect PSA-triggered peptide cleavage events.

Abstract: The present invention is directed to the diagnosis of cancer associated with enzymatically active PSA in samples.

Abstract: A bicycle chain for improved endurance includes pairs of substantially identical plates. Each plate has a generally oval shape, with, in one embodiment, a generally centrally located indentation along an inner edge. A pair of plates is orientable with the respective inner faces of the first and the second end portions parallel and opposed. A spacing between inner faces of the first end portions is thereby less than a spacing between the inner faces of the second end portions. A pivot pin extends through the second end portion hole of a first plate through a first end portion hole of a third plate, through a spacer body, through a first end portion hole of a fourth plate, and through the second end portion hole of the second plate, the pivot pin rotatably anchored adjacent the outer faces of the first and the second plates.

Abstract: An improved seal-insert and seal for a toner hopper as used in toner cartridge assemblies for printers, copiers and facsimile machines. In one embodiment, the seal has two slotted, rectangular outer pieces joined together with slot alignment and joined by an inner layer of two-sided tape. The two-sided tape is made with a long u-shape which does not interfere with the slots in the outer pieces. The open end of the u-shaped tape configuration allows a seal to be inserted or removed from between the outer pieces to close or open the slots. The seal-insert is applied over the passage from the toner hopper. The outer pieces are made from an antistatic and/or a conductive material, such as an aluminum laminate or plastic imprefnated with conductive particles. Alternately, the outer pieces may be made from plastic covered with an antistatic and/or conductive spray or coating.

Abstract: A bicycle chain for improved endurance includes pairs of substantially identical plates. Each oval plate has opposed first and second end portions joined by an outwardly stepped portion. Each end portion has a hole therethrough. A pair of plates is orientable with the respective inner faces of the first and the second end portions parallel and opposed. A spacing between inner faces of the first end portions is thereby less than a spacing between the inner faces of the second end portions. A pivot pin extends through the second end portion hole of a first plate through a first end portion hole of a third plate, through a spacer body, through a first end portion hole of a fourth plate, and through the second end portion hole of the second plate, the pivot pin rotatably anchored adjacent the outer faces of the first and the second plates.

Abstract: An image forming apparatus, toner cartridge assembly and toner hopper having a seal-insert and tear-style seal-assembly in the toner hopper as used in toner cartridge assemblies for dry toner style printers, copiers and facsimile machines. The seal-assembly may have a short grip portion where the seal installation personnel may pull on both the short grip portion and the pull-strip simultaneously to control and guide the seal-assembly into position in the toner hopper with ease. Methods to install and manufacture are also included.

Abstract: An improved seal-insert and seal for a toner hopper as used in toner cartridge assemblies for printers, copiers and facsimile machines. In one embodiment, the seal has two slotted, rectangular outer pieces joined together with slot alignment and joined by an inner layer of two-sided tape. The two-sided tape is made with a long u-shape which does not interfere with the slots in the outer pieces. The open end of the u-shaped tape configuration allows a seal to be inserted or removed from between the outer pieces to close or open the slots. The seal-insert is applied over the passage from the toner hopper. The outer pieces are made from an antistatic and/or a conductive material, such as an aluminum laminate or plastic impregnated with conductive particles. Alternately, the outer pieces may be made from plastic covered with an antistatic and/or conductive spray or coating.

Abstract: Diagnostics and treatments for bacterial infection are disclosed. The treatments prevent bacteria from adhering to host cells by interfering with the binding of the bacteria to cell receptors. Compounds that inhibit bacterial adherence to cells are engineered to be readily modified for best efficacy with different modes of treatment. The compounds can be readily modified for use to identify bacteria according to their cell binding specificities.

Abstract: An information display system and method for displaying information on multiple information display means. The information display system is generally comprised of a system controller, one or more direct controller, multiple information display units and one or more display lines, which facilitate the transmission of operating power and information to the information display units. The system controller combines each unit of source information with its own address code, thereby forming an addressed information unit. The system controller transmits the addressed information unit to a direct controller designated by said information unit's address code.

Abstract: A lightweight shade apparatus constructed of a plurality of intersecting ribs extending radially outwardly, the ribs being covered by bowed cross members adapted to fit over the ribs and to be affixed thereto by a cooperating circumferential belt, the belt functioning also to secure a covering over the top of the bowed cross members.