Patents by Inventor Byung-Gee Kim

Byung-Gee Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12139733
    Abstract: The present application relates to a variant of ornithine decarboxylase or protein, a polynucleotide encoding the same, a microorganism containing the same, and a method for producing putrescine using the same. The present invention achieves effects of increasing putrescine productivity, production efficiency or production selectivity, suppressing side reactions, and saving the cost involved in purifying putrescine.
    Type: Grant
    Filed: December 24, 2019
    Date of Patent: November 12, 2024
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Jaehun Lee, Hee-See Moon, Ae Ji Jeon, Young Lyeol Yang, Byung-Gee Kim, Eun Young Hong
  • Patent number: 12097276
    Abstract: A composition contains, as an effective component, theasinensin A, an enantiomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition has an excellent stability and provides wrinkle-reducing or skin elasticity-enhancing benefits, and skin-brightening benefits by containing theasinensin A, an enantiomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, as an effective component.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: September 24, 2024
    Assignees: AMOREPACIFIC CORPORATION, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Eun Mi Kim, Kyeonghwan Hwang, Dong Hyun Kim, Byung-Gee Kim, Jinkyung Choi
  • Publication number: 20230287382
    Abstract: The present application relates to a variant of ornithine decarboxylase or protein, a polynucleotide encoding the same, a microorganism containing the same, and a method for producing putrescine using the same. The present invention achieves effects of increasing putrescine productivity, production efficiency or production selectivity, suppressing side reactions, and saving the cost involved in purifying putrescine.
    Type: Application
    Filed: December 24, 2019
    Publication date: September 14, 2023
    Inventors: Jaehun LEE, Hee-See MOON, Ae Ji JEON, Young Lyeol YANG, Byung-Gee KIM, Eun Young HONG
  • Publication number: 20230135337
    Abstract: The present invention relates to a method of co-incubating multiple cells. According to the present invention, an interaction between the multiple cells is facilitated without causing cytotoxicity, and a single cell can be separated without damage to the cells. Therefore, the present invention can be applied to a study of regeneration on various types of tissue cells.
    Type: Application
    Filed: April 5, 2021
    Publication date: May 4, 2023
    Inventors: Nathaniel Suk-Yeon HWANG, Byung-Gee KIM, Minji KIM
  • Patent number: 11389568
    Abstract: The present invention relates to a biopolymer-based hydrogel as a functional biomaterial produced by crosslinking in the presence of a photopolymerization initiator. The hydrogel of the present invention is elastic so as to be adapted to various shapes in both in vivo and in vitro applications. It is biocompatible, achieving maximum effects on wound healing as wound dressing and tissue adhesion preventing material. The present invention also relates to a method for producing the biocompatible hydrogel.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: July 19, 2022
    Assignee: Science@Home Inc.
    Inventors: Yoon Sik Lee, Byung Gee Kim, Sung Jun Park, Sang Hyuk Lee
  • Publication number: 20220000742
    Abstract: A composition contains, as an effective component, theasinensin A, an enantiomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition has an excellent stability and provides wrinkle-reducing or skin elasticity-enhancing benefits, and skin-brightening benefits by containing theasinensin A, an enantiomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, as an effective component.
    Type: Application
    Filed: November 6, 2019
    Publication date: January 6, 2022
    Applicants: AMOREPACIFIC CORPORATION, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Eun Mi KIM, Kyeonghwan HWANG, Dong Hyun KIM, Byung-Gee KIM, Jinkyung CHOI
  • Publication number: 20210230657
    Abstract: The present invention relates to a cross-linked material having adhesion prepared by using tyrosinase derived from Burkholderia, preparation method thereof and application thereof, and specifically relates to the hydrogel composition having adhesiveness. The hydrogel composition having adhesiveness of the present invention is injectable through an injection or spraying, and can be used in 3D printing or preparation of adhesive hydrogel medical film, etc.
    Type: Application
    Filed: May 10, 2019
    Publication date: July 29, 2021
    Inventors: Byung Gee Kim, Uk Jae Lee, Sang Hyuk Lee, Hyun Kim
  • Patent number: 10676732
    Abstract: The present invention relates to a method for producing a lysine carboxylase mutant strain, characteristics of the mutant strain, a gene encoding the lysine decarboxylase mutant strain, and a method for producing cadaverine using the same. The present invention provides lysine decarboxylase derived from E. coli improved through a protein engineering variation. In addition, the lysine decarboxylase mutant strain of the present invention increases activity, pH stability, and thermal stability at the time of producing cadaverine, thereby reducing production costs, through increasing a yield and productivity.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: June 9, 2020
    Assignee: Seoul National University R&DB Foundation
    Inventors: Byung Gee Kim, Eun Young Hong
  • Publication number: 20190314556
    Abstract: The present invention relates to a biopolymer-based hydrogel as a functional biomaterial produced by crosslinking in the presence of a photopolymerization initiator. The hydrogel of the present invention is elastic so as to be adapted to various shapes in both in vivo and in vitro applications. It is biocompatible, achieving maximum effects on wound healing as wound dressing and tissue adhesion preventing material. The present invention also relates to a method for producing the biocompatible hydrogel.
    Type: Application
    Filed: April 29, 2019
    Publication date: October 17, 2019
    Inventors: Yoon Sik LEE, Byung Gee KIM, Sung Jun PARK, Sang Hyuk LEE
  • Patent number: 10336990
    Abstract: The present invention provides an ?-1,3 fucosyltransferase mutant having an increased expression level of soluble protein and increased activity, a DNA encoding the ?-1,3 fucosyltransferase mutant, a recombinant vector comprising the DNA encoding the ?-1,3 fucosyltransferase mutant, a host cell transformed with the recombinant DNA vector, an extract of the host cell, a method for producing 3-fucosyloligosaccharide, a method for preparing an ?-1,3 fucosyltransferase mutant, and a method for screening an ?-1,3 fucosyltransferase mutant. The ?-1,3 fucosyltransferase mutant of the present invention has a significantly increased soluble protein expression level and activity.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: July 2, 2019
    Assignee: Seoul National University R&DB Foundation
    Inventors: Byung Gee Kim, Yun Hee Choi
  • Publication number: 20180291362
    Abstract: The present invention relates to a method for producing a lysine carboxylase mutant strain, characteristics of the mutant strain, a gene encoding the lysine decarboxylase mutant strain, and a method for producing cadaverine using the same. The present invention provides lysine decarboxylase derived from E. coli improved through a protein engineering variation. In addition, the lysine decarboxylase mutant strain of the present invention increases activity, pH stability, and thermal stability at the time of producing cadaverine, thereby reducing production costs, through increasing a yield and productivity.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 11, 2018
    Inventors: Byung Gee KIM, Eun Young HONG
  • Patent number: 9783489
    Abstract: The present invention relates to a pharmaceutical composition and a cosmetic composition, which contain, as an active ingredient, a novel pseudo compound having similar structural characteristics to natural ceramide 1, or a pharmaceutically acceptable salt or solvate thereof, and the composition containing the compound of the present invention as an active ingredient has an excellent effect of enhancing a skin barrier function, thereby exhibiting an effect of alleviating inflammatory skin diseases, and has an excellent skin barrier improving function and an excellent skin moisturization enhancing effect.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: October 10, 2017
    Assignee: NEOPHARM CO., LTD.
    Inventors: Se Kyoo Jeong, Bong Woo Kim, Bu Mahn Park, Jeong Eun Jeon, Byung Gee Kim
  • Publication number: 20170247668
    Abstract: The present invention provides an ?-1,3 fucosyltransferase mutant having an increased expression level of soluble protein and increased activity, a DNA encoding the ?-1,3 fucosyltransferase mutant, a recombinant vector comprising the DNA encoding the ?-1,3 fucosyltransferase mutant, a host cell transformed with the recombinant DNA vector, an extract of the host cell, a method for producing 3-fucosyloligosaccharide, a method for preparing an ?-1,3 fucosyltransferase mutant, and a method for screening an ?-1,3 fucosyltransferase mutant. The ?-1,3 fucosyltransferase mutant of the present invention has a significantly increased soluble protein expression level and activity.
    Type: Application
    Filed: June 22, 2015
    Publication date: August 31, 2017
    Inventors: Byung Gee KIM, Yun Hee CHOI
  • Patent number: 9637768
    Abstract: The present invention relates to a method for preparing a sialic acid derivative characterized by performing both of a process for preparing CMP-N-acetylneuraminic acid using N-acetyl-D-glucosamine and a process for preparing the sialic acid (neuraminic acid) derivative that combines a sialic acid with a galactose derivative or a lactose derivative, together, in one reactor. According to the method for preparing a sialic acid derivative of the present invention, expensive cytidine 5?-monophosphate (CMP) is capable of being recycled in a reactor, such that an amount of the CMP introduced into the reactor may be reduced, and the sialic acid derivative is capable of being prepared at a significantly high efficiency by using cheap N-acetyl-D-glucosamine, and pyruvate as substrates.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: May 2, 2017
    Assignee: GENECHEM INC.
    Inventors: Jin Suk Woo, Byung-Gee Kim, Dae Hee Kim, Yun Hee Choi, Jae-Kyung Song, Sun Youp Kang, Won Min Seo, Ji Young Yang, Sang Mi Lee
  • Publication number: 20170036995
    Abstract: The present invention relates to a pharmaceutical composition and a cosmetic composition, which contain, as an active ingredient, a novel pseudo compound having similar structural characteristics to natural ceramide 1, or a pharmaceutically acceptable salt or solvate thereof, and the composition containing the compound of the present invention as an active ingredient has an excellent effect of enhancing a skin barrier function, thereby exhibiting an effect of alleviating inflammatory skin diseases, and has an excellent skin barrier improving function and an excellent skin moisturization enhancing effect.
    Type: Application
    Filed: December 23, 2014
    Publication date: February 9, 2017
    Inventors: Se Kyoo JEONG, Bong Woo KIM, Bu Mahn PARK, Jeong Eun JEON, Byung Gee KIM
  • Patent number: 9394562
    Abstract: The present invention relates to the novel Rhizobium sp. GIN611 KCTC11708BP or to cell extracts thereof, to a novel oxidoreductase which exhibits a glycolytic activity, to a gene encoding the oxidoreductase, to a recombinant strain comprising recombinant vector proteins or to an expression vector encoding recombinant proteins, and to a method for the glycolysis of natural products using same as a biocatalyst. The present invention also relates to a method for producing aglycones from a variety of natural products using same. The novel oxidoreductase separated from the novel microorganism of the present invention does not belong to a glucosidase group but belongs to an oxidoreductase group, and has a glycolytic activity for natural products. The novel oxidoreductase oxidizes the sugar in the aglycones of natural products, thereby producing a variety of aglycones.
    Type: Grant
    Filed: January 2, 2015
    Date of Patent: July 19, 2016
    Assignees: AMOREPACIFIC CORPORATION, SNU R&DB FOUNDATION
    Inventors: Jun Seong Park, Duck Hee Kim, Han Kon Kim, Eun Mi Kim, Byung Gee Kim
  • Publication number: 20160130621
    Abstract: The present invention relates to a method for preparing a sialic acid derivative characterized by performing both of a process for preparing CMP-N-acetylneuraminic acid using N-acetyl-D-glucosamine and a process for preparing the sialic acid (neuraminic acid) derivative that combines a sialic acid with a galactose derivative or a lactose derivative, together, in one reactor. According to the method for preparing a sialic acid derivative of the present invention, expensive cytidine 5?-monophosphate (CMP) is capable of being recycled in a reactor, such that an amount of the CMP introduced into the reactor may be reduced, and the sialic acid derivative is capable of being prepared at a significantly high efficiency by using cheap N-acetyl-D-glucosamine, and pyruvate as substrates.
    Type: Application
    Filed: May 30, 2014
    Publication date: May 12, 2016
    Inventors: Jin Suk Woo, Byung-Gee Kim, Dae Hee Kim, Yun Hee Choi, Jae-Kyung Song, Sun Youp Kang, Won Min Seo, Ji Young Yang, Sang Mi Lee
  • Publication number: 20150184216
    Abstract: The present invention relates to the novel Rhizobium sp. GIN611 KCTC11708BP or to cell extracts thereof, to a novel oxidoreductase which exhibits a glycolytic activity, to a gene encoding the oxidoreductase, to a recombinant strain comprising recombinant vector proteins or to an expression vector encoding recombinant proteins, and to a method for the glycolysis of natural products using same as a biocatalyst. The present invention also relates to a method for producing aglycones from a variety of natural products using same. The novel oxidoreductase separated from the novel microorganism of the present invention does not belong to a glucosidase group but belongs to an oxidoreductase group, and has a glycolytic activity for natural products. The novel oxidoreductase oxidizes the sugar in the aglycones of natural products, thereby producing a variety of aglycones.
    Type: Application
    Filed: January 2, 2015
    Publication date: July 2, 2015
    Inventors: Jun Seong PARK, Duck Hee KIM, Han Kon KIM, Eun Mi KIM, Byung Gee KIM
  • Patent number: 8852891
    Abstract: The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: October 7, 2014
    Assignee: Gene Chem, Inc.
    Inventors: Jin Suk Woo, Jae Kyung Sohng, Byung Gee Kim, Sun Youp Kang, Dea Hee Kim, Kyoung Soon Jang, Ji Young Yang, Young Soo Jung, Won Min Seo, Tae Geon Gil, Sang Hee Shim, In Kang Hur
  • Publication number: 20130084601
    Abstract: The present invention relates to the novel Rhizobium sp. GIN611 KCTC11708BP or to cell extracts thereof, to a novel oxidoreductase which exhibits a glycolytic activity, to a gene encoding the oxidoreductase, to a recombinant strain comprising recombinant vector proteins or to an expression vector encoding recombinant proteins, and to a method for the glycolysis of natural products using same as a biocatalyst. The present invention also relates to a method for producing aglycones from a variety of natural products using same. The novel oxidoreductase separated from the novel microorganism of the present invention does not belong to a glucosidase group but belongs to an oxidoreductase group, and has a glycolytic activity for natural products. The novel oxidoreductase oxidizes the sugar in the aglycones of natural products, thereby producing a variety of aglycones.
    Type: Application
    Filed: June 14, 2011
    Publication date: April 4, 2013
    Applicant: AMOREPACIFIC CORPORATION
    Inventors: Jun Seong Park, Duck Hee Kim, Han Kon Kim, Eun Mi Kim, Byung Gee Kim