Abstract: Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof, wherein R1, R2, R3, R4, R5, R6, Ra, x, y, L, G, Z, the bond denoted by “q”, the ring system denoted by “A” and the ring system denoted by “B” are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORy activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORy activity, for example, autoimmune and/or inflammatory disorders.

Abstract: The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.

Abstract: An apparatus and method for adaptive layer selection and a server having the same are provided. The adaptive layer selecting apparatus includes a monitoring unit monitoring a connection state of at least one channel connected through a communication network, a channel managing unit detecting available channels to be used for providing a service based on a result of the monitoring, and a layer managing unit determining the number of adaptive layers to be used for encoding based on bandwidths of changed available channels when the number of the available channels is changed.

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Abstract: A scalable video coding apparatus and method for realistic broadcasting are provided. The scalable video coding apparatus may include a spatial scalable coding unit to perform intra-view predictive coding in base layers of a color image and a depth image and prediction in enhancement layers by referencing motion information of the base layer, a signal-to-noise ratio (SNR) scalable coding unit to perform coding using quantization which is a method for SNR scalability of the color image, and a motion estimation device to code the base layer of the depth image using the motion information of the base layer of the color image as prediction data.

Abstract: This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Abstract: Provided are moving picture encoding apparatus and method skipping intra prediction in encoding mode determination using rate-distortion (RD) costs and determining an encoding mode at high speed. The moving picture encoding method includes the steps of: setting the lowest one of rate-distortion costs of macroblocks adjacent to a macroblock to be encoded as a threshold value; setting the lowest one of mode-specific distortion costs obtained by inter prediction for the macroblock to be encoded as an optimum inter mode distortion cost; comparing the threshold value with the optimum inter mode distortion cost; and when the threshold value is larger than the optimum inter mode distortion cost, as a result of the comparison, skipping intra prediction and setting a mode having the optimum inter mode distortion cost as a final encoding mode.

Abstract: A device for eliminating a block artifact phenomenon of a decoded image frame, and an eliminating method thereof. A method for eliminating a block artifact phenomenon according to the present invention includes: extracting pixel information including a magnitude of edge response, an edge direction, and an edge position, by applying an edge detector to an arbitrary pixel in an image frame; distinguishing the pixel into a non-edge pixel, an object edge pixel, or a block edge pixel by using the extracted pixel information; and performing filtering according to the distinguishing result. In this manner, an object edge information is selectively protected, so that an improved image quality may be provided.

Abstract: Provided is a fast mode-searching apparatus and method for motion-prediction. The fast mode-searching apparatus includes a probability information obtaining unit, a first inter mode searching unit, a second inter mode searching unit, and a selective intra mode searching unit. The probability information obtaining unit detects whether at least one of a macroblock of a previous frame, a macroblock of a current frame, and adjacent macroblocks corresponds to at least one of P16×16, P16×8, and P8×16. The first inter mode searching unit performs an inter mode search on a block that is not detected by the probability information obtaining unit. The second inter mode searching unit determines whether the macroblock of the current frame corresponds to P16×16 as a result of performing the inter mode search on a block detected by the probability information obtaining unit. The selective intra mode searching unit performs an intra mode search if the macroblock of the current frame corresponds to P16×16.

Abstract: A fast motion estimation apparatus and method in which motion estimation is carried out on a current block of a current frame of video image data with reference to a corresponding matching block of a previous frame are provided.

Abstract: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract: This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Abstract: The present invention relates to a method for a video encoder to determine an inter mode. The video encoder selects first search modes by using optimized inter mode information of a correlation macroblock having the same position as a current macroblock in a previous frame, in order to determine the inter mode. The video encoder compares a rate-distortion cost of the correlation macroblock and a rate-distortion cost of the mode that is selected as the minimum cost mode from among the first search modes, and determines whether to terminate an inter mode determination process early. When the early termination condition is satisfied, the video encoder determines the search mode having the minimum rate-distortion cost from among the first search modes as the optimized inter mode of the current macroblock, and terminates the inter mode determination process early.

Abstract: The present invention relates to a method for a video encoder to determine an inter mode. The video encoder selects initial candidate modes by using inter mode information of a previous frame so as to determine the inter mode, estimates a macroblock having the greatest correlation with a current macroblock in the previous frame, compares the rate-distortion cost of the corresponding macroblock and the rate-distortion cost of the selected mode from among the initial candidate modes, and determines whether to terminate the inter mode determination process early. When the early termination condition is satisfied, the video encoder determines the candidate mode having the minimum rate-distortion cost from among the initial candidate modes as the inter mode of the current macroblock, and terminates the inter mode determination process early.

Abstract: Provided is an intra-mode prediction search method for compression of a real-time video signal, the method including the steps of: measuring a Rate-Distortion (R-D) cost of a video-signal macro block received from outside; determining a search threshold value by comparing the R-D cost of the received macro block with R-D costs of neighboring macro blocks; determining an inter mode having the minimum sum of absolute error (SAE) by measuring the SAE of the received macro block for each inter mode; and determining an intra-mode prediction search in response to the minimum SAE of the determined inter mode and the search threshold value.