Abstract: The present disclosure relates to a method and apparatus for diagnosing urinary disturbances by simultaneously measuring a urinary flow rate and residual urine. The method for diagnosing urinary disturbances according to the present disclosure includes obtaining at least one ultrasonic image of a bladder for each unit time from a patient who is urinating, obtaining at least one urine region image for each unit time from the at least one ultrasonic image for each unit time, calculating at least one estimated urine volume for each unit time based on an area of the at least one urine region image for each unit time, calculating at least one parameter value with respect to urinary disturbances based on the at least one estimated urine volume for each unit time, and outputting the at least one parameter value.

Abstract: The present disclosure relates to a method and apparatus for diagnosing urinary disturbances by simultaneously measuring a urinary flow rate and residual urine. The method for diagnosing urinary disturbances according to the present disclosure includes obtaining at least one ultrasonic image of a bladder for each unit time from a patient who is urinating, obtaining at least one urine region image for each unit time from the at least one ultrasonic image for each unit time, calculating at least one estimated urine volume for each unit time based on an area of the at least one urine region image for each unit time, calculating at least one parameter value with respect to urinary disturbances based on the at least one estimated urine volume for each unit time, and outputting the at least one parameter value.

Abstract: The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-? and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII.

Abstract: The present invention relates to a composition for preventing or treating mitochondrial diseases caused by immunosuppressants, and immune diseases, containing metformin and, more specifically, to a composition for treating mitochondrial diseases caused by immunosuppressants, containing metformin; a pharmaceutical composition for preventing or treating immune diseases, containing, as active ingredients, metformin and an immunosuppressant, which is a target of rapamycin inhibitor (mTOR inhibitor); and a pharmaceutical composite formulation for preventing or treating immune diseases, containing, as ingredients, metformin and a mammalian target of rapamycin inhibitor, wherein the metformin and mammalian target of rapamycin inhibitor are administered simultaneously or separately, or administered in a predetermined sequence.

Abstract: The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-? and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII.

Abstract: A text-to-speech method for simulating a plurality of different voice characteristics includes dividing inputted text into a sequence of acoustic units; selecting voice characteristics for the inputted text; converting the sequence of acoustic units to a sequence of speech vectors using an acoustic model having a plurality of model parameters provided in clusters each having at least one sub-cluster and describing probability distributions which relate an acoustic unit to a speech vector; and outputting the sequence of speech vectors as audio with the selected voice characteristics. A parameter of a predetermined type of each probability distribution is expressed as a weighted sum of parameters of the same type using voice characteristic dependent weighting. In converting the sequence of acoustic units to a sequence of speech vectors, the voice characteristic dependent weights for the selected voice characteristics are retrieved for each cluster such that there is one weight per sub-cluster.

Abstract: The present invention relates to a method and a kit for monitoring an immune status after transplant. The kit for monitoring an immune status after transplant and the method for monitoring an immune status of an individual after transplant as provided in the present invention make it easy and accurate to determine an immune status in the individual after transplant and thus have an effect of reducing overuse of an immunosuppressive agent prescribed after transplant and also have an effect of conveniently managing an immune status of each patient.

Abstract: The present invention relates to a method and a kit for monitoring an immune status after transplant. The kit for monitoring an immune status after transplant and the method for monitoring an immune status of an individual after transplant as provided in the present invention make it easy and accurate to determine an immune status in the individual after transplant and thus have an effect of reducing overuse of an immunosuppressive agent prescribed after transplant and also have an effect of conveniently managing an immune status of each patient.

Abstract: A text-to-speech method for simulating a plurality of different voice characteristics includes dividing inputted text into a sequence of acoustic units; selecting voice characteristics for the inputted text; converting the sequence of acoustic units to a sequence of speech vectors using an acoustic model having a plurality of model parameters provided in clusters each having at least one sub-cluster and describing probability distributions which relate an acoustic unit to a speech vector; and outputting the sequence of speech vectors as audio with the selected voice characteristics. A parameter of a predetermined type of each probability distribution is expressed as a weighted sum of parameters of the same type using voice characteristic dependent weighting. In converting the sequence of acoustic units to a sequence of speech vectors, the voice characteristic dependent weights for the selected voice characteristics are retrieved for each cluster such that there is one weight per sub-cluster.