Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: The present disclosure relates to an ultraviolet light-blocking composition containing a centipede grass extract and a cosmetic composition and, more specifically, to an ultraviolet light-blocking composition comprising a centipede grass (Eremochloa ophiuroides) leaf extract as an active ingredient; and a cosmetic composition containing the ultraviolet light-blocking composition.

Abstract: An oral cleaning composition in ingestible tablet or powder formulation contains natural materials. It has an advantage of portability because it is provided in a tablet or powder form instead of a liquid or gel form. In addition, the composition does not contain synthetic chemical components but uses only natural materials and can be safely ingested after use, and, thus, it does not require a space where it can be spit out. Furthermore, it exhibits excellent efficacy in inhibiting oral bacteria and removing bad breath.

Abstract: An oral cleaning composition in ingestible tablet or powder formulation contains natural materials. It has an advantage of portability because it is provided in a tablet or powder form instead of a liquid or gel form. In addition, the composition does not contain synthetic chemical components but uses only natural materials and can be safely ingested after use, and, thus, it does not require a space where it can be spit out. Furthermore, it exhibits excellent efficacy in inhibiting oral bacteria and removing bad breath.